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RhoGAP1A Rho GTPase activating protein at 1A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740235, updated on 25-Jan-2024

Summary

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Official Symbol
RhoGAP1Aprovided by FlyBase
Official Full Name
Rho GTPase activating protein at 1Aprovided by FlyBase
Primary source
FLYBASE:FBgn0025836
Locus tag
Dmel_CG40494
See related
AllianceGenome:FB:FBgn0025836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A
Old locus tag
Dmel_CG00000
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in Golgi organization and negative regulation of cell size. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic brain; embryonic/larval midgut; germline cell; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human ABR (ABR activator of RhoGEF and GTPase) and BCR (BCR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
1A1-1A1; 1-0 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (127449..140340)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (23836..36727)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR40469 Neighboring gene uncharacterized protein Neighboring gene mir-4915 stem loop Neighboring gene long non-coding RNA:CR45473 Neighboring gene uncharacterized protein Neighboring gene trynity

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
  2. Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity. Sailem H, et al. Open Biol, 2014 Jan 22. PMID 24451547, Free PMC Article
  3. Recombination, dominance and selection on amino acid polymorphism in the Drosophila genome: contrasting patterns on the X and fourth chromosomes. Sheldahl LA, et al. Genetics, 2003 Nov. PMID 14668375, Free PMC Article
  4. Branch-restricted localization of phosphatase Prl-1 specifies axonal synaptogenesis domains. Urwyler O, et al. Science, 2019 May 3. PMID 31048465
  5. Feedback inhibition of actin on Rho mediates content release from large secretory vesicles. Segal D, et al. J Cell Biol, 2018 May 7. PMID 29496739, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: 130043-130141 mobile_element_type = transposon:INE-1{}4621
  • Loc: 130273-130671 mobile_element_type = transposon:INE-1{}4623
  • Loc: 135061-135784 mobile_element_type = transposon:INE-1{}4645

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho GTPase activating protein at 1A
Names
CG40494-PA
CG40494-PB
CG40494-PC
CG40494-PD
CG40494-PE
CG40494-PF
RhoGAP1A-PA
RhoGAP1A-PB
RhoGAP1A-PC
RhoGAP1A-PD
RhoGAP1A-PE
RhoGAP1A-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    127449..140340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297796.1 → NP_001284725.1  Rho GTPase activating protein at 1A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284725.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JC00
    Conserved Domains (4) summary
    smart00325
    Location:675 → 857
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:851 → 1037
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl02570
    Location:1203 → 1398
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl14603
    Location:1079 → 1187
    C2; C2 domain

  2. NM_001297795.1 → NP_001284724.1  Rho GTPase activating protein at 1A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284724.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J9V9
    Conserved Domains (4) summary
    smart00325
    Location:673 → 855
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:849 → 1035
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl02570
    Location:1201 → 1396
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl14603
    Location:1077 → 1185
    C2; C2 domain

  3. NM_001103385.2 → NP_001096855.1  Rho GTPase activating protein at 1A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096855.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29QE1
    Conserved Domains (4) summary
    smart00325
    Location:674 → 856
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:850 → 1036
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl02570
    Location:1202 → 1397
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl14603
    Location:1078 → 1186
    C2; C2 domain

  4. NM_001103386.2 → NP_001096856.1  Rho GTPase activating protein at 1A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096856.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29QE1
    Conserved Domains (4) summary
    smart00325
    Location:674 → 856
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:850 → 1036
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl02570
    Location:1202 → 1397
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl14603
    Location:1078 → 1186
    C2; C2 domain

  5. NM_001169155.1 → NP_001162626.1  Rho GTPase activating protein at 1A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162626.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C560
    Conserved Domains (3) summary
    smart00325
    Location:366 → 548
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:542 → 728
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl14603
    Location:770 → 878
    C2; C2 domain

  6. NM_001297797.1 → NP_001284726.1  Rho GTPase activating protein at 1A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284726.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C560
    Conserved Domains (3) summary
    smart00325
    Location:366 → 548
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13368
    Location:542 → 728
    PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl14603
    Location:770 → 878
    C2; C2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C1C560 C1C560
O96833 O96833
Q29QE1 Q29QE1
Q6W434 Q6W434
Q6W435 Q6W435
Q6W436 Q6W436
Q6W437 Q6W437
Q6W453 Q6W453
Q6W456 Q6W456
Q8MSA6 Q8MSA6
Q95TE3 Q95TE3
Q9XZS6 Q9XZS6
X2J9V9 X2J9V9
X2JC00 X2JC00

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