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Cramp1 cramped chromatin regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 57354, updated on 11-Apr-2024

Summary

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Official Symbol
Cramp1provided by MGI
Official Full Name
cramped chromatin regulator 1provided by MGI
Primary source
MGI:MGI:1930190
See related
Ensembl:ENSMUSG00000038002 AllianceGenome:MGI:1930190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tce4; Cramp1l; mKIAA1426; 5830477H08Rik
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in pattern specification process. Predicted to be active in nucleus. Orthologous to human CRAMP1 (cramped chromatin regulator homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 13.4), limb E14.5 (RPKM 12.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.53 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25180200..25234819, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24961226..25015840, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E7499 Neighboring gene STARR-positive B cell enhancer ABC_E1500 Neighboring gene Jupiter microtubule associated homolog 2 Neighboring gene STARR-positive B cell enhancer ABC_E396 Neighboring gene intraflagellar transport 140 Neighboring gene STARR-positive B cell enhancer ABC_E11631 Neighboring gene transmembrane protein 204 Neighboring gene telomere maintenance 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers. Mendez-Frausto G, et al. Exp Mol Pathol, 2021 Dec. PMID 34592200
  2. Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Kargul GJ, et al. Genome Res, 2000 Jul. PMID 10899141, Free PMC Article
  3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers.
    Title: Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1426

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein cramped-like
Names
Crm, cramped-like
cramped chromatin regulator homolog 1
hematological and neurological expressed 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403565.1 → NP_001390494.1  protein cramped-like

    Status: VALIDATED

    Source sequence(s)
    AC154229
    UniProtKB/Swiss-Prot
    E9QNA8, Q6PG95, Q6ZPR3
    Related
    ENSMUSP00000156906.2, ENSMUST00000233774.2

  2. NM_020608.3 → NP_065633.2  protein cramped-like

    See identical proteins and their annotated locations for NP_065633.2

    Status: VALIDATED

    Source sequence(s)
    AK030991, AK089393, AK147411, BE946250
    Consensus CDS
    CCDS50030.1
    UniProtKB/Swiss-Prot
    E9QNA8, Q6PG95, Q6ZPR3
    Related
    ENSMUSP00000073060.7, ENSMUST00000073337.8
    Conserved Domains (2) summary
    PHA03309
    Location:441 → 619
    PHA03309; transcriptional regulator ICP4; Provisional
    pfam04642
    Location:125 → 205
    DUF601; Protein of unknown function, DUF601

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25180200..25234819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524703.5 → XP_006524766.1  protein cramped-like isoform X1

    See identical proteins and their annotated locations for XP_006524766.1

    UniProtKB/Swiss-Prot
    E9QNA8, Q6PG95, Q6ZPR3
    Conserved Domains (2) summary
    PHA03309
    Location:441 → 619
    PHA03309; transcriptional regulator ICP4; Provisional
    pfam04642
    Location:125 → 205
    DUF601; Protein of unknown function, DUF601

  2. XM_017317589.3 → XP_017173078.1  protein cramped-like isoform X1

    UniProtKB/Swiss-Prot
    E9QNA8, Q6PG95, Q6ZPR3
    Conserved Domains (2) summary
    PHA03309
    Location:441 → 619
    PHA03309; transcriptional regulator ICP4; Provisional
    pfam04642
    Location:125 → 205
    DUF601; Protein of unknown function, DUF601

  3. XM_006524699.4 → XP_006524762.1  protein cramped-like isoform X2

    Conserved Domains (2) summary
    PHA03309
    Location:491 → 669
    PHA03309; transcriptional regulator ICP4; Provisional
    pfam04642
    Location:175 → 255
    DUF601; Protein of unknown function, DUF601

  4. XM_011246545.3 → XP_011244847.1  protein cramped-like isoform X3

    Conserved Domains (2) summary
    PHA03309
    Location:441 → 619
    PHA03309; transcriptional regulator ICP4; Provisional
    pfam04642
    Location:125 → 205
    DUF601; Protein of unknown function, DUF601
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PG95.3 GenPept UniProtKB/Swiss-Prot:Q6PG95

Gene LinkOut

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