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ZNF304 zinc finger protein 304 [ Homo sapiens (human) ]

Gene ID: 57343, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF304provided by HGNC
Official Full Name
zinc finger protein 304provided by HGNC
Primary source
HGNC:HGNC:13505
See related
Ensembl:ENSG00000131845 MIM:613840; AllianceGenome:HGNC:13505
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein functions as a transcriptional repressor that recruits a corepressor complex to stimulate promoter hypermethylation and transcriptional silencing of target genes. Expression of this gene is upregulated in colorectal, ovarian and breast cancer, and this gene may promote cancer cell survival, growth and invasion. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in thyroid (RPKM 4.2), spleen (RPKM 3.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57351271..57359898)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60448301..60456928)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57862639..57871266)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPPDE peptidase domain containing 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:57830216-57830733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15132 Neighboring gene zinc finger protein 543 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:57861815-57862674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:57862675-57863533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15136 Neighboring gene trafficking protein particle complex subunit 2B Neighboring gene zinc finger protein 547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15138 Neighboring gene zinc finger protein 548

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The ZNF304-integrin axis protects against anoikis in cancer. Aslan B, et al. Nat Commun, 2015 Jun 17. PMID 26081979, Free PMC Article
  2. Identification of a KRAB-containing zinc finger protein, ZNF304, by AU-motif-directed display method and initial characterization in lymphocyte activation. Sabater L, et al. Biochem Biophys Res Commun, 2002 May 10. PMID 12051768
  3. Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latency. Krasnopolsky S, et al. PLoS Pathog, 2020 Sep. PMID 32956422, Free PMC Article
  4. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Serra RW, et al. Elife, 2014 Mar 12. PMID 24623306, Free PMC Article
  5. Proteome-scale mapping of binding sites in the unstructured regions of the human proteome. Benz C, et al. Mol Syst Biol, 2022 Jan. PMID 35044719, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latency.
    Title: Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latency.
  2. transcriptional regulator of beta1 integrin, promotes cancer cell survival and protects against anoikis in ovarian cancer
    Title: The ZNF304-integrin axis protects against anoikis in cancer.
  3. Identification of ZNF304, by AU-motif-directed display method and characterization of its role in lymphocyte activation
    Title: Identification of a KRAB-containing zinc finger protein, ZNF304, by AU-motif-directed display method and initial characterization in lymphocyte activation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC129703, MGC129704

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 304
Names
KRAB-containing zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051201.1 RefSeqGene

    Range
    5019..13646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290318.2 → NP_001277247.1  zinc finger protein 304 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC005261, BC111532, BP315423
    Consensus CDS
    CCDS77365.1
    UniProtKB/TrEMBL
    E7EQD3
    Related
    ENSP00000401642.2, ENST00000443917.6
    Conserved Domains (3) summary
    COG5048
    Location:325 → 680
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:384 → 404
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:13 → 53
    KRAB; KRAB box

  2. NM_001290319.2 → NP_001277248.1  zinc finger protein 304 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC005261, BC111531, BP315423
    Consensus CDS
    CCDS74462.1
    UniProtKB/TrEMBL
    M0QZ59
    Related
    ENSP00000470319.1, ENST00000598744.1
    Conserved Domains (3) summary
    COG5048
    Location:236 → 591
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:295 → 315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:307 → 332
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001329456.2 → NP_001316385.1  zinc finger protein 304 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC005261

  4. NM_020657.4 → NP_065708.2  zinc finger protein 304 isoform 2

    See identical proteins and their annotated locations for NP_065708.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC005261, BC111532, BP315423
    Consensus CDS
    CCDS12950.1
    UniProtKB/Swiss-Prot
    Q9HCX3
    Related
    ENSP00000282286.4, ENST00000282286.6
    Conserved Domains (5) summary
    smart00349
    Location:14 → 55
    KRAB; krueppel associated box
    COG5048
    Location:278 → 633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:337 → 357
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:349 → 374
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57351271..57359898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527145.3 → XP_011525447.1  zinc finger protein 304 isoform X1

    See identical proteins and their annotated locations for XP_011525447.1

    Conserved Domains (3) summary
    COG5048
    Location:283 → 638
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:342 → 362
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:354 → 379
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60448301..60456928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321521.1 → XP_054177496.1  zinc finger protein 304 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HCX3.2 GenPept UniProtKB/Swiss-Prot:Q9HCX3

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