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Gigyf1 GRB10 interacting GYF protein 1 [ Mus musculus (house mouse) ]

Gene ID: 57330, updated on 5-Mar-2024

Summary

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Official Symbol
Gigyf1provided by MGI
Official Full Name
GRB10 interacting GYF protein 1provided by MGI
Primary source
MGI:MGI:1888677
See related
Ensembl:ENSMUSG00000029714 AllianceGenome:MGI:1888677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Perq1; mKIAA4110
Summary
Acts upstream of or within insulin-like growth factor receptor signaling pathway. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and spleen. Orthologous to human GIGYF1 (GRB10 interacting GYF protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 27.6), ovary adult (RPKM 21.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gigyf1 in Genome Data Viewer
Location:
5 G2; 5 76.53 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137508470..137526197)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137510263..137527935)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137943213-137943434 Neighboring gene RIKEN cDNA 9130604C24 gene Neighboring gene processing of precursor 7, ribonuclease P family, (S. cerevisiae) Neighboring gene microRNA 6418 Neighboring gene guanine nucleotide binding protein (G protein), beta 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137974329-137974544 Neighboring gene STARR-positive B cell enhancer ABC_E1692 Neighboring gene predicted gene 17112

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice. Ding Z, et al. Biol Psychiatry, 2023 Nov 15. PMID 36924980,
  2. GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Giovannone B, et al. Hum Mol Genet, 2009 Dec 1. PMID 19744960, Free PMC Article
  3. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. Giovannone B, et al. J Biol Chem, 2003 Aug 22. PMID 12771153
  4. GIGYF1 disruption associates with autism and impaired IGF-1R signaling. Chen G, et al. J Clin Invest, 2022 Oct 3. PMID 35917186, Free PMC Article
  5. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Wilson MD, et al. Nucleic Acids Res, 2001 Mar 15. PMID 11239002, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice.
    Title: Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice.
  2. identification of proteins linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling
    Title: Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA4110

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GRB10-interacting GYF protein 1
Names
GRB10 interacting GYF protein 2
PERQ amino acid rich, with GYF domain 1
PERQ amino acid-rich with GYF domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403315.1 → NP_001390244.1  GRB10-interacting GYF protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC148018
    UniProtKB/Swiss-Prot
    Q571A0, Q6Y7W9, Q99MR1

  2. NM_001403317.1 → NP_001390246.1  GRB10-interacting GYF protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC148018

  3. NM_031408.3 → NP_113596.2  GRB10-interacting GYF protein 1 isoform a

    See identical proteins and their annotated locations for NP_113596.2

    Status: VALIDATED

    Source sequence(s)
    AC148018
    Consensus CDS
    CCDS51673.1
    UniProtKB/Swiss-Prot
    Q571A0, Q6Y7W9, Q99MR1
    Related
    ENSMUSP00000031727.8, ENSMUST00000031727.10
    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:478 → 531
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137508470..137526197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165379.1 → XP_036021272.1  GRB10-interacting GYF protein 1 isoform X7

    UniProtKB/Swiss-Prot
    Q571A0, Q6Y7W9, Q99MR1
    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:478 → 531
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  2. XM_030254735.1 → XP_030110595.1  GRB10-interacting GYF protein 1 isoform X5

    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:478 → 531
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  3. XM_006504609.4 → XP_006504672.1  GRB10-interacting GYF protein 1 isoform X3

    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:506 → 559
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  4. XM_011240952.3 → XP_011239254.1  GRB10-interacting GYF protein 1 isoform X2

    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:506 → 559
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  5. XM_011240953.3 → XP_011239255.1  GRB10-interacting GYF protein 1 isoform X4

    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:506 → 559
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  6. XM_036165380.1 → XP_036021273.1  GRB10-interacting GYF protein 1 isoform X8

    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:478 → 531
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  7. XM_011240950.3 → XP_011239252.1  GRB10-interacting GYF protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011239252.1

    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:506 → 559
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  8. XM_006504608.4 → XP_006504671.1  GRB10-interacting GYF protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006504671.1

    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:506 → 559
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  9. XM_006504607.4 → XP_006504670.1  GRB10-interacting GYF protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006504670.1

    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:506 → 559
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  10. XM_030254736.2 → XP_030110596.1  GRB10-interacting GYF protein 1 isoform X6

    Conserved Domains (2) summary
    PRK12678
    Location:113 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:477 → 530
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MR1.2 GenPept UniProtKB/Swiss-Prot:Q99MR1

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