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Retnla resistin like alpha [ Mus musculus (house mouse) ]

Gene ID: 57262, updated on 21-Apr-2024

Summary

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Official Symbol
Retnlaprovided by MGI
Official Full Name
resistin like alphaprovided by MGI
Primary source
MGI:MGI:1888504
See related
Ensembl:ENSMUSG00000061100 AllianceGenome:MGI:1888504
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HIMF; Xcp2; Fizz1; RELMa; Fizz-1; RELMalpha; RELM-alpha; 1810019L16Rik
Summary
Predicted to enable hormone activity. Located in extracellular region. Is expressed in heart; mammary gland; respiratory system; tongue; and white fat. Orthologous to human RETNLB (resistin like beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 357.7), subcutaneous fat pad adult (RPKM 170.8) and 3 other tissues See more
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Genomic context

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Location:
16 B5; 16 30.75 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48662972..48664824)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48842609..48844461)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene T cell receptor associated transmembrane adaptor 1 Neighboring gene TWIST neighbor pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:48788868-48789191 Neighboring gene resistin like beta Neighboring gene resistin like gamma Neighboring gene STARR-seq mESC enhancer starr_40961 Neighboring gene STARR-seq mESC enhancer starr_40962 Neighboring gene STARR-positive B cell enhancer mm9_chr16:48942004-48942304 Neighboring gene DAZ interacting protein 3, zinc finger Neighboring gene predicted gene, 22576

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Macrophage-Regulatory T Cell Interactions Promote Type 2 Immune Homeostasis Through Resistin-Like Molecule α. Li J, et al. Front Immunol, 2021. PMID 34349768, Free PMC Article
  2. HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype. Li Y, et al. Basic Res Cardiol, 2021 Apr 23. PMID 33893593, Free PMC Article
  3. The adipokine Retnla deficiency increases responsiveness to cardiac repair through adiponectin-rich bone marrow cells. Kim YS, et al. Cell Death Dis, 2021 Mar 22. PMID 33753732, Free PMC Article
  4. In situ evidence of collagen V and signaling pathway of found inflammatory zone 1 (FIZZ1) is associated with silicotic granuloma in lung mice. Martins V, et al. Pathol Res Pract, 2020 Sep. PMID 32825961
  5. RELMα Licenses Macrophages for Damage-Associated Molecular Pattern Activation to Instigate Pulmonary Vascular Remodeling. Lin Q, et al. J Immunol, 2019 Dec 1. PMID 31611261, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Choline metabolism underpins macrophage IL-4 polarization and RELMalpha up-regulation in helminth infection.
    Title: Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection.
  2. Macrophage-Regulatory T Cell Interactions Promote Type 2 Immune Homeostasis Through Resistin-Like Molecule alpha.
    Title: Macrophage-Regulatory T Cell Interactions Promote Type 2 Immune Homeostasis Through Resistin-Like Molecule α.
  3. HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype.
    Title: HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype.
  4. In situ evidence of collagen V and signaling pathway of found inflammatory zone 1 (FIZZ1) is associated with silicotic granuloma in lung mice.
    Title: In situ evidence of collagen V and signaling pathway of found inflammatory zone 1 (FIZZ1) is associated with silicotic granuloma in lung mice.
  5. RELMalpha is Induced in Airway Epithelial Cells by Oncostatin M Without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo.
    Title: RELMα is Induced in Airway Epithelial Cells by Oncostatin M Without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo.
  6. The RELMalpha/hresistin-induced macrophage-specific HMGB1/RAGE expression and facilitated HMGB1 nucleus-to-cytoplasm translocation and extracellular secretion.
    Title: RELMα Licenses Macrophages for Damage-Associated Molecular Pattern Activation to Instigate Pulmonary Vascular Remodeling.
  7. RELMalpha-expressing macrophages were essential to prevent fatal lung damage during primary N. brasiliensis infection and to provide protective immunity against migrating parasites during secondary challenge.
    Title: RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection.
  8. In HIMF-induced PH, HMGB1-RAGE signaling is pivotal for mediating EC-smooth muscle cell crosstalk. The humanized mouse data further support clinical implications for the HIMF/HMGB1 signaling axis and indicate that hResistin and its downstream pathway may constitute targets for the development of novel anti-PH therapeutics in humans.
    Title: HIMF (Hypoxia-Induced Mitogenic Factor) Signaling Mediates the HMGB1 (High Mobility Group Box 1)-Dependent Endothelial and Smooth Muscle Cell Crosstalk in Pulmonary Hypertension.
  9. Here, the authors show that resistin-like molecule alpha (RELMalpha), a small secreted cysteine-rich protein, is expressed by epidermal keratinocytes and sebocytes and serves as an antimicrobial protein that is required for vitamin-A-dependent resistance to skin infection.
    Title: Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin.
  10. B cells produced high levels of the tissue-protective protein, Resistin-like molecule alpha (RELMalpha), which then downregulated IL-17A expression.
    Title: B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema.
Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
resistin-like alpha
Names
cysteine-rich secreted protein A12-gamma
cysteine-rich secreted protein FIZZ1
found in inflammatory zone 1
hypoxia-induced mitogenic factor
parasite-induced macrophage novel gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020509.4 → NP_065255.3  resistin-like alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC154529
    Consensus CDS
    CCDS49864.2
    UniProtKB/Swiss-Prot
    Q9D8Y4, Q9EP95
    UniProtKB/TrEMBL
    Q78ZN4, Q8JZM3
    Related
    ENSMUSP00000159097.2, ENSMUST00000238847.2
    Conserved Domains (1) summary
    pfam06954
    Location:23 → 110
    Resistin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    48662972..48664824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EP95.1 GenPept UniProtKB/Swiss-Prot:Q9EP95

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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