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Ltb4r2 leukotriene B4 receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 57260, updated on 11-Apr-2024

Summary

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Official Symbol
Ltb4r2provided by MGI
Official Full Name
leukotriene B4 receptor 2provided by MGI
Primary source
MGI:MGI:1888501
See related
Ensembl:ENSMUSG00000040432 AllianceGenome:MGI:1888501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BLT2; LTB4-R2; LTB4-R 2; LTB4-R-2; 5830462O07Rik
Summary
Enables leukotriene B4 receptor activity. Acts upstream of or within keratinocyte migration and signal transduction. Located in membrane. Orthologous to human LTB4R2 (leukotriene B4 receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 18.1), small intestine adult (RPKM 13.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Ltb4r2 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55995379..56001523)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55757922..55764066)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase 1 Neighboring gene NOP9 nucleolar protein Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector B Neighboring gene STARR-seq mESC enhancer starr_36778 Neighboring gene leukotriene B4 receptor 1 Neighboring gene adenylate cyclase 4 Neighboring gene predicted gene, 32092

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Contributory Role of BLT2 in the Production of Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced Sepsis. Park D, et al. Mol Cells, 2021 Dec 31. PMID 34887363, Free PMC Article
  2. Leukotriene B(4) Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation. Matsumoto Y, et al. J Pharmacol Exp Ther, 2020 Apr. PMID 31941716
  3. Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B(4) receptor 2. Iwamoto S, et al. Sci Rep, 2017 Oct 16. PMID 29038497, Free PMC Article
  4. Selective inhibition of leukotriene receptor BLT-2 reduces vascular oxidative stress and improves endothelial function in ApoE-/- mice. Hoyer FF, et al. Mol Cell Biochem, 2012 Jan. PMID 21755457
  5. BLT2 Is upregulated in allergen-stimulated mast cells and mediates the synthesis of Th2 cytokines. Cho KJ, et al. J Immunol, 2010 Nov 15. PMID 20952677

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation.
    Title: Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation.
  2. Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.
    Title: Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.
  3. Contributory Role of BLT2 in the Production of Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced Sepsis.
    Title: Contributory Role of BLT2 in the Production of Proinflammatory Cytokines in Cecal Ligation and Puncture-Induced Sepsis.
  4. Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
    Title: Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
  5. Leukotriene B4 receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production.
    Title: Leukotriene B(4) receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production.
  6. Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation.
    Title: Leukotriene B(4) Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation.
  7. FABP4 regulates the expression of BLT1R and its downstream signaling via control of oxidative stress in macrophages
    Title: Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling.
  8. findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response.
    Title: Lipopolysaccharide/TLR4 Stimulates IL-13 Production through a MyD88-BLT2-Linked Cascade in Mast Cells, Potentially Contributing to the Allergic Response.
  9. This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL
    Title: Macrophage LTB(4) drives efficient phagocytosis of Borrelia burgdorferi via BLT1 or BLT2.
  10. BLT2 expression in mast cells is essential for the production of VEGF in OVA-induced allergic asthma.
    Title: Leukotriene B4 Receptor 2 Is Critical for the Synthesis of Vascular Endothelial Growth Factor in Allergen-Stimulated Mast Cells.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC123942, MGC123943

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene B4 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene B4 receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables leukotriene receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within keratinocyte migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leukotriene B4 receptor 2
Names
leukotriene B4 receptor BLT2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020490.3 → NP_065236.1  leukotriene B4 receptor 2

    See identical proteins and their annotated locations for NP_065236.1

    Status: VALIDATED

    Source sequence(s)
    AC098877
    Consensus CDS
    CCDS27128.1
    UniProtKB/Swiss-Prot
    Q3KP98, Q9JJL9
    Related
    ENSMUSP00000048358.5, ENSMUST00000044554.5
    Conserved Domains (2) summary
    cd14964
    Location:23 → 47
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:21 → 300
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55995379..56001523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519323.3 → XP_006519386.1  leukotriene B4 receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_006519386.1

    Conserved Domains (2) summary
    cd14964
    Location:34 → 60
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006519326.3 → XP_006519389.1  leukotriene B4 receptor 2 isoform X2

    See identical proteins and their annotated locations for XP_006519389.1

    UniProtKB/Swiss-Prot
    Q3KP98, Q9JJL9
    Conserved Domains (2) summary
    cd14964
    Location:23 → 47
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:21 → 300
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_036158769.1 → XP_036014662.1  leukotriene B4 receptor 2 isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:34 → 60
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJL9.1 GenPept UniProtKB/Swiss-Prot:Q9JJL9

Gene LinkOut

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