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Xpo4 exportin 4 [ Mus musculus (house mouse) ]

Gene ID: 57258, updated on 11-Apr-2024

Summary

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Official Symbol
Xpo4provided by MGI
Official Full Name
exportin 4provided by MGI
Primary source
MGI:MGI:1888526
See related
Ensembl:ENSMUSG00000021952 AllianceGenome:MGI:1888526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1721; B430309A01Rik
Summary
Predicted to enable nuclear export signal receptor activity. Predicted to be involved in positive regulation of protein export from nucleus and protein export from nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human XPO4 (exportin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 4.9), CNS E11.5 (RPKM 4.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Xpo4 in Genome Data Viewer
Location:
14 C3; 14 30.11 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (57814978..57906951, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57577521..57668232, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene EEF1A alpha lysine methyltransferase 1 Neighboring gene RIKEN cDNA 1700039M10 gene Neighboring gene STARR-positive B cell enhancer ABC_E5445 Neighboring gene STARR-seq mESC enhancer starr_36813 Neighboring gene large tumor suppressor 2 Neighboring gene predicted gene, 26440 Neighboring gene STARR-seq mESC enhancer starr_36814 Neighboring gene predicted gene, 52140

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs. Chen L, et al. Nat Commun, 2022 Oct 1. PMID 36182935, Free PMC Article
  2. Identification of radiation-responsive genes in vitro using a gene trap strategy predicts for modulation of expression by radiation in vivo. Vallis KA, et al. Radiat Res, 2002 Jan. PMID 11754636
  3. Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors. Gontan C, et al. J Cell Biol, 2009 Apr 6. PMID 19349578, Free PMC Article
  4. Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. Lipowsky G, et al. EMBO J, 2000 Aug 15. PMID 10944119, Free PMC Article
  5. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Olthof AM, et al. Nucleic Acids Res, 2021 Apr 6. PMID 33660780, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs.
    Title: Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs.
  2. Exp4 (exportin 4) is an interaction partner of Sox2 in mouse embryonic stem cells and neural progenitors.
    Title: Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear export signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nuclear transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exportin-4
Names
exp4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368697.1 → NP_001355626.1  exportin-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154504, AC154675, AK084907
    UniProtKB/Swiss-Prot
    E9QLH3, Q6ZPJ4, Q9ESJ0

  2. NM_001368698.1 → NP_001355627.1  exportin-4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154504
    UniProtKB/TrEMBL
    Q3TQK5
    Conserved Domains (1) summary
    smart00913
    Location:37 → 103
    IBN_N; Importin-beta N-terminal domain

  3. NM_020506.2 → NP_065252.1  exportin-4 isoform 1

    See identical proteins and their annotated locations for NP_065252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154504, AC154675
    Consensus CDS
    CCDS56961.1
    UniProtKB/Swiss-Prot
    E9QLH3, Q6ZPJ4, Q9ESJ0
    UniProtKB/TrEMBL
    A0A0R4J254
    Related
    ENSMUSP00000133280.2, ENSMUST00000174545.9

RNA

  1. NR_160870.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154504, AK163558

  2. NR_160871.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154504, AK021022

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    57814978..57906951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247900.2 → XP_030103760.1  exportin-4 isoform X2

    UniProtKB/Swiss-Prot
    E9QLH3, Q6ZPJ4, Q9ESJ0

  2. XM_036158768.1 → XP_036014661.1  exportin-4 isoform X1

    UniProtKB/Swiss-Prot
    E9QLH3, Q6ZPJ4, Q9ESJ0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESJ0.2 GenPept UniProtKB/Swiss-Prot:Q9ESJ0

Gene LinkOut

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