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ACTR3B actin related protein 3B [ Homo sapiens (human) ]

Gene ID: 57180, updated on 5-Mar-2024

Summary

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Official Symbol
ACTR3Bprovided by HGNC
Official Full Name
actin related protein 3Bprovided by HGNC
Primary source
HGNC:HGNC:17256
See related
Ensembl:ENSG00000133627 AllianceGenome:HGNC:17256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP11; ARP3BETA
Summary
This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Broad expression in brain (RPKM 3.7), testis (RPKM 1.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ACTR3B in Genome Data Viewer
Location:
7q36.1-q36.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (152759752..152855378)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (153933015..154028620)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (152456837..152552463)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26884 Neighboring gene Sharpr-MPRA regulatory region 2063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26885 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 845, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:152542780-152542923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152543205-152543792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152543793-152544380 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:152547394-152548593 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:152580535-152581290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152591520-152592087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152592088-152592654 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:152665473-152666348 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:152666349-152667224 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:152667225-152668099 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:152683335-152684085 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:152685957-152686952 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:152686953-152687946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152740735-152741234 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:152744087-152745286 Neighboring gene MPRA-validated peak6860 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:152780188-152781036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:152781037-152781883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152796011-152796512 Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene uncharacterized LOC102723686 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:152887976-152889175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:152890387-152890887 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:152900290-152901489 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:152955709-152956222 Neighboring gene Sharpr-MPRA regulatory region 3392

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Derangement of hypothetical proteins in fetal Down's syndrome brain. Shin JH, et al. Neurochem Res, 2004 Jun. PMID 15176487
  2. The Arp2/3 complex: a multifunctional actin organizer. Machesky LM, et al. Curr Opin Cell Biol, 1999 Feb. PMID 10047519
  3. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. Shindo-Okada N, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14651955
  4. Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. Shindo-Okada N, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162478
  5. ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. Jay P, et al. Eur J Biochem, 2000 May. PMID 10806390

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. Thus, overexpression of Arp11 may suppress tumorigenicity in nude mice.
    Title: Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686O24114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
actin-related protein 3B
Names
ARP3 actin related protein 3 homolog B
ARP3-beta
actin-like protein 3B
actin-related protein 3-beta
actin-related protein ARP4
actin-related protein Arp11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040135.3 → NP_001035225.1  actin-related protein 3B isoform 2

    See identical proteins and their annotated locations for NP_001035225.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AA559050, AB209174, AK294292, BC015207, DN601600
    Consensus CDS
    CCDS34782.1
    UniProtKB/TrEMBL
    Q59FV6
    Related
    ENSP00000367007.3, ENST00000377776.7
    Conserved Domains (1) summary
    cl25542
    Location:2 → 347
    Actin; Actin

  2. NM_001350940.2 → NP_001337869.1  actin-related protein 3B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 4, 5, and 6, encodes isoform 3.
    Source sequence(s)
    AC072057, AC092180
    Consensus CDS
    CCDS87568.1
    UniProtKB/TrEMBL
    B7Z9W3
    Related
    ENSP00000380452.2, ENST00000397282.2
    Conserved Domains (1) summary
    PTZ00280
    Location:1 → 329
    PTZ00280; Actin-related protein 3; Provisional

  3. NM_001350941.2 → NP_001337870.1  actin-related protein 3B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform 3.
    Source sequence(s)
    AC072057, AC092180
    Consensus CDS
    CCDS87568.1
    UniProtKB/TrEMBL
    B7Z9W3
    Conserved Domains (1) summary
    PTZ00280
    Location:1 → 329
    PTZ00280; Actin-related protein 3; Provisional

  4. NM_001350942.2 → NP_001337871.1  actin-related protein 3B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform 3.
    Source sequence(s)
    AC072057, AC092180
    Consensus CDS
    CCDS87568.1
    UniProtKB/TrEMBL
    B7Z9W3
    Conserved Domains (1) summary
    PTZ00280
    Location:1 → 329
    PTZ00280; Actin-related protein 3; Provisional

  5. NM_001350943.2 → NP_001337872.1  actin-related protein 3B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 3, 4, and 5, encodes isoform 3.
    Source sequence(s)
    AC072057, AC092180
    Consensus CDS
    CCDS87568.1
    UniProtKB/TrEMBL
    B7Z9W3
    Conserved Domains (1) summary
    PTZ00280
    Location:1 → 329
    PTZ00280; Actin-related protein 3; Provisional

  6. NM_001350944.2 → NP_001337873.1  actin-related protein 3B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
    UniProtKB/TrEMBL
    B4DT29
    Conserved Domains (1) summary
    cl25542
    Location:2 → 375
    Actin

  7. NM_001350945.2 → NP_001337874.1  actin-related protein 3B isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
    UniProtKB/TrEMBL
    Q59GD5
    Conserved Domains (1) summary
    PTZ00280
    Location:1 → 288
    PTZ00280; Actin-related protein 3; Provisional

  8. NM_001350946.2 → NP_001337875.1  actin-related protein 3B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180
    Conserved Domains (1) summary
    cl25542
    Location:1 → 259
    Actin; Actin

  9. NM_020445.6 → NP_065178.1  actin-related protein 3B isoform 1

    See identical proteins and their annotated locations for NP_065178.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA559050, AB209174, AK315534, DN601600
    Consensus CDS
    CCDS5934.1
    UniProtKB/Swiss-Prot
    A8MTG1, B4DFW4, Q7Z526, Q96BT2, Q9P1U1
    UniProtKB/TrEMBL
    Q59FV6
    Related
    ENSP00000256001.8, ENST00000256001.13
    Conserved Domains (1) summary
    PTZ00280
    Location:2 → 417
    PTZ00280; Actin-related protein 3; Provisional

RNA

  1. NR_146946.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180

  2. NR_146947.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180

  3. NR_146948.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180

  4. NR_146949.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180

  5. NR_146950.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180

  6. NR_146951.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC072057, AC092180

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    152759752..152855378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    153933015..154028620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P1U1.1 GenPept UniProtKB/Swiss-Prot:Q9P1U1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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