Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Tat
|
tat
|
Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation |
PubMed
|
|
tat
|
HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome |
PubMed
|
|
tat
|
HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex |
PubMed
|
|
tat
|
HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function |
PubMed
|
Vif
|
vif
|
HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication |
PubMed
|
integrase
|
gag-pol
|
Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway |
PubMed
|
Go to the HIV-1, Human Interaction Database