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ZNF695 zinc finger protein 695 [ Homo sapiens (human) ]

Gene ID: 57116, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF695provided by HGNC
Official Full Name
zinc finger protein 695provided by HGNC
Primary source
HGNC:HGNC:30954
See related
Ensembl:ENSG00000197472 MIM:616348; AllianceGenome:HGNC:30954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBZF3
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
1q44
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (246945546..247008057, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (246377209..246439658, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247108848..247171359, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:246957595-246958236 Neighboring gene long intergenic non-protein coding RNA 1341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2861 Neighboring gene MPRA-validated peak823 silencer Neighboring gene MPRA-validated peak824 silencer Neighboring gene AT-hook containing transcription factor 1 Neighboring gene MPRA-validated peak825 silencer Neighboring gene MPRA-validated peak826 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2863 Neighboring gene ZNF670-ZNF695 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2865 Neighboring gene Sharpr-MPRA regulatory region 11618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:247165417-247165917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2041 Neighboring gene zinc finger protein 519 pseudogene Neighboring gene DNA primase subunit 1 pseudogene Neighboring gene zinc finger protein 670

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy. Takahashi T, et al. J Cancer Res Clin Oncol, 2015 Mar. PMID 25273507
  2. Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer. Juárez-Méndez S, et al. J Ovarian Res, 2013 Sep 5. PMID 24007497, Free PMC Article
  3. Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm. Chen J, et al. Front Immunol, 2022. PMID 36311753, Free PMC Article
  4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm.
    Title: Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm.
  2. ZNF695 methylation was associated with the response to definitive chemoradiotherapy in esophageal squamous cell carcinoma.
    Title: ZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ZNF670-ZNF695

Readthrough gene: ZNF670-ZNF695, Included gene: ZNF670

Homology

Clone Names

  • MGC61907

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 695
Names
zinc finger protein SBZF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204221.2 → NP_001191150.2  zinc finger protein 695 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113174, AL512637
    Consensus CDS
    CCDS55694.1
    Related
    ENSP00000429736.1, ENST00000487338.6
    Conserved Domains (1) summary
    smart00349
    Location:4 → 76
    KRAB; krueppel associated box

  2. NM_020394.5 → NP_065127.5  zinc finger protein 695 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL512637
    Consensus CDS
    CCDS44344.1
    UniProtKB/Swiss-Prot
    Q5T0N9, Q5T0P1, Q5T0P3, Q7Z2W8, Q7Z648, Q8IW36
    Related
    ENSP00000341236.7, ENST00000339986.8
    Conserved Domains (3) summary
    smart00349
    Location:4 → 76
    KRAB; krueppel associated box
    COG5048
    Location:148 → 515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:354 → 374
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_037892.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate exon structure in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113174, AL512637
    Related
    ENST00000366504.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    246945546..247008057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    246377209..246439658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IW36.4 GenPept UniProtKB/Swiss-Prot:Q8IW36

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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