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DUS3L dihydrouridine synthase 3 like [ Homo sapiens (human) ]

Gene ID: 56931, updated on 3-Apr-2024

Summary

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Official Symbol
DUS3Lprovided by HGNC
Official Full Name
dihydrouridine synthase 3 likeprovided by HGNC
Primary source
HGNC:HGNC:26920
See related
Ensembl:ENSG00000141994 AllianceGenome:HGNC:26920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUS3
Summary
Enables RNA binding activity. Predicted to be involved in tRNA dihydrouridine synthesis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 13.5), bone marrow (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (5785140..5791163, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (5771937..5778591, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5785151..5791174, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit delta Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5780743-5780921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13816 Neighboring gene proline rich 22 Neighboring gene Sharpr-MPRA regulatory region 11822 Neighboring gene neurturin Neighboring gene Sharpr-MPRA regulatory region 2060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5827746-5828434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9936 Neighboring gene fucosyltransferase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation. Dai W, et al. Nat Chem Biol, 2021 Nov. PMID 34556860, Free PMC Article
  2. Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2. Wang C, et al. Nat Commun, 2020 Jun 22. PMID 32572027, Free PMC Article
  3. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
  4. Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation. Finet O, et al. Mol Cell, 2022 Jan 20. PMID 34798057, Free PMC Article
  5. Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome. Barbosa JAF, et al. J Virol, 2021 Jul 12. PMID 34011540, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13896

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA dihydrouridine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dihydrouridine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA dihydrouridine synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA dihydrouridine synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
Names
mRNA-dihydrouridine synthase DUS3L
NP_001155091.1
NP_064560.2
XP_016882509.1
XP_047295067.1
XP_054177483.1
XP_054177484.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161619.2 → NP_001155091.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 2

    See identical proteins and their annotated locations for NP_001155091.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC004549
    Consensus CDS
    CCDS54202.1
    UniProtKB/Swiss-Prot
    Q96G46
    Related
    ENSP00000315558.7, ENST00000320699.12
    Conserved Domains (2) summary
    COG0042
    Location:55 → 334
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd02801
    Location:64 → 296
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  2. NM_020175.3 → NP_064560.2  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 1

    See identical proteins and their annotated locations for NP_064560.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011499, AK315691, BC008362
    Consensus CDS
    CCDS32880.1
    UniProtKB/Swiss-Prot
    Q96G46, Q96HM5, Q9BSU4, Q9H877, Q9NPR1
    UniProtKB/TrEMBL
    B2RDV7
    Related
    ENSP00000311977.5, ENST00000309061.12
    Conserved Domains (2) summary
    COG0042
    Location:297 → 576
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd02801
    Location:306 → 538
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    5785140..5791163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027020.2 → XP_016882509.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X1

    UniProtKB/TrEMBL
    B2RDV7

  2. XM_047439111.1 → XP_047295067.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X2

RNA

  1. XR_244033.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    5771937..5778591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321508.1 → XP_054177483.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X1

  2. XM_054321509.1 → XP_054177484.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X2

RNA

  1. XR_008485167.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96G46.2 GenPept UniProtKB/Swiss-Prot:Q96G46

Gene LinkOut

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