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TMEM167B transmembrane protein 167B [ Homo sapiens (human) ]

Gene ID: 56900, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM167Bprovided by HGNC
Official Full Name
transmembrane protein 167Bprovided by HGNC
Primary source
HGNC:HGNC:30187
See related
Ensembl:ENSG00000215717 AllianceGenome:HGNC:30187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD-020; C1orf119
Summary
Involved in constitutive secretory pathway. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 27.7), prostate (RPKM 22.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109090764..109096934)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109123630..109129800)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (109633386..109639556)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109609757-109610560 Neighboring gene TATA-box binding protein associated factor 13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109616882-109617868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1434 Neighboring gene TMEM167B divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1435 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109641577-109642336 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109642337-109643096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109643857-109644615 Neighboring gene small Cajal body-specific RNA 2 Neighboring gene poly(rC) binding protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856, Free PMC Article
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Hu RM, et al. Proc Natl Acad Sci U S A, 2000 Aug 15. PMID 10931946, Free PMC Article
  3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in constitutive secretory pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein kish-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322248.2 → NP_001309177.1  protein kish-B isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC008739, BC067116, BG724370, BP240791
    Consensus CDS
    CCDS91014.1
    UniProtKB/TrEMBL
    A0A494C0V7
    Related
    ENSP00000498719.1, ENST00000651489.1
    Conserved Domains (1) summary
    pfam06842
    Location:11 → 46
    DUF1242; Protein of unknown function (DUF1242)

  2. NM_020141.4 → NP_064526.1  protein kish-B isoform 1 precursor

    See identical proteins and their annotated locations for NP_064526.1

    Status: VALIDATED

    Source sequence(s)
    AL356488, BC008739
    Consensus CDS
    CCDS30789.1
    UniProtKB/Swiss-Prot
    B2RUU9, Q9NRX6
    Related
    ENSP00000342148.7, ENST00000338272.9
    Conserved Domains (1) summary
    pfam06842
    Location:11 → 46
    DUF1242; Protein of unknown function (DUF1242)

RNA

  1. NR_136242.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC008739, BC067116, BG724370, BX331284

  2. NR_136243.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC008739, BC067116, BG724370, DA782106

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    109090764..109096934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    109123630..109129800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRX6.1 GenPept UniProtKB/Swiss-Prot:Q9NRX6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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