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Rnf32 ring finger protein 32 [ Mus musculus (house mouse) ]

Gene ID: 56874, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf32provided by MGI
Official Full Name
ring finger protein 32provided by MGI
Primary source
MGI:MGI:1861747
See related
Ensembl:ENSMUSG00000029130 AllianceGenome:MGI:1861747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lmbr2; 1700009J01Rik; 2700025B22Rik; 4930542N22Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be located in several cellular components, including aggresome; endosome; and nuclear body. Is expressed in several structures, including alimentary system; genitourinary system; limb; olfactory epithelium; and trunk. Orthologous to human RNF32 (ring finger protein 32). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 24.5), CNS E18 (RPKM 2.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B1; 5 14.78 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (29397743..29432633)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (29192745..29227635)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35688 Neighboring gene Shh brain enhancer 3 Neighboring gene STARR-seq mESC enhancer starr_12726 Neighboring gene predicted gene, 35881 Neighboring gene STARR-seq mESC enhancer starr_12727 Neighboring gene mammal reptile conserved sequence 1 Neighboring gene STARR-seq mESC enhancer starr_12728 Neighboring gene mammal fish conserved sequence 3 Neighboring gene STARR-seq mESC enhancer starr_12729 Neighboring gene mammal fish conserved sequence 4 Neighboring gene predicted gene 7420 Neighboring gene mammal amphibian conserved sequence 1 Neighboring gene limb region 1 Neighboring gene STARR-seq mESC enhancer starr_12732 Neighboring gene STARR-seq mESC enhancer starr_12733 Neighboring gene STARR-seq mESC enhancer starr_12734 Neighboring gene zone of polarising activity regulatory sequence 1 Neighboring gene STARR-positive B cell enhancer ABC_E9634 Neighboring gene predicted gene, 36086

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization. Sagai T, et al. Proc Natl Acad Sci U S A, 2019 Nov 19. PMID 31685615, Free PMC Article
  2. A double RING-H2 domain in RNF32, a gene expressed during sperm formation. van Baren MJ, et al. Biochem Biophys Res Commun, 2002 Mar 22. PMID 11890671
  3. The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances. Symmons O, et al. Dev Cell, 2016 Dec 5. PMID 27867070, Free PMC Article
  4. Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription. Amano T, et al. Dev Cell, 2009 Jan. PMID 19097946
  5. Mapping the Shh long-range regulatory domain. Anderson E, et al. Development, 2014 Oct. PMID 25252942, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC107158

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RING finger protein 32
Names
limb region protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289757.1 → NP_001276686.1  RING finger protein 32

    See identical proteins and their annotated locations for NP_001276686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK012288, AV284199, BC089493, BY293373
    Consensus CDS
    CCDS39041.1
    UniProtKB/Swiss-Prot
    Q9D9X0, Q9DAJ3, Q9JIT1
    Related
    ENSMUSP00000001247.6, ENSMUST00000001247.12
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:294 → 361
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  2. NM_021470.6 → NP_067445.3  RING finger protein 32

    See identical proteins and their annotated locations for NP_067445.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK005795, AK012288, AV284199, BC089493, BY293373
    Consensus CDS
    CCDS39041.1
    UniProtKB/Swiss-Prot
    Q9D9X0, Q9DAJ3, Q9JIT1
    Related
    ENSMUSP00000124657.2, ENSMUST00000160246.8
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:294 → 361
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

RNA

  1. NR_110371.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK012288, AV284199, BY293373
    Related
    ENSMUST00000160383.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    29397743..29432633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535775.4 → XP_006535838.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_006535838.1

    UniProtKB/Swiss-Prot
    Q9D9X0, Q9DAJ3, Q9JIT1
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:294 → 361
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  2. XM_030254724.1 → XP_030110584.1  RING finger protein 32 isoform X2

    UniProtKB/TrEMBL
    F6URG7
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:238 → 305
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  3. XM_006535781.4 → XP_006535844.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_006535844.1

    UniProtKB/Swiss-Prot
    Q9D9X0, Q9DAJ3, Q9JIT1
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:294 → 361
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  4. XM_036165367.1 → XP_036021260.1  RING finger protein 32 isoform X4

    Conserved Domains (2) summary
    cd16678
    Location:128 → 195
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:24 → 43
    IQ; IQ calmodulin-binding motif

  5. XM_006535780.3 → XP_006535843.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_006535843.1

    UniProtKB/Swiss-Prot
    Q9D9X0, Q9DAJ3, Q9JIT1
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:294 → 361
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  6. XM_036165368.1 → XP_036021261.1  RING finger protein 32 isoform X4

    Conserved Domains (2) summary
    cd16678
    Location:128 → 195
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:24 → 43
    IQ; IQ calmodulin-binding motif

  7. XM_036165363.1 → XP_036021256.1  RING finger protein 32 isoform X2

    UniProtKB/TrEMBL
    F6URG7
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:238 → 305
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  8. XM_036165366.1 → XP_036021259.1  RING finger protein 32 isoform X4

    Conserved Domains (2) summary
    cd16678
    Location:128 → 195
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:24 → 43
    IQ; IQ calmodulin-binding motif

  9. XM_036165365.1 → XP_036021258.1  RING finger protein 32 isoform X3

    UniProtKB/TrEMBL
    F6URG7
    Conserved Domains (3) summary
    cd16677
    Location:54 → 97
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:220 → 287
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:116 → 135
    IQ; IQ calmodulin-binding motif

  10. XM_006535778.3 → XP_006535841.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_006535841.1

    UniProtKB/Swiss-Prot
    Q9D9X0, Q9DAJ3, Q9JIT1
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:294 → 361
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  11. XM_006535782.3 → XP_006535845.1  RING finger protein 32 isoform X2

    UniProtKB/TrEMBL
    F6URG7
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:238 → 305
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  12. XM_017321036.1 → XP_017176525.1  RING finger protein 32 isoform X4

    Conserved Domains (2) summary
    cd16678
    Location:128 → 195
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:24 → 43
    IQ; IQ calmodulin-binding motif

  13. XM_030254726.1 → XP_030110586.1  RING finger protein 32 isoform X4

    Conserved Domains (2) summary
    cd16678
    Location:128 → 195
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:24 → 43
    IQ; IQ calmodulin-binding motif

  14. XM_030254725.1 → XP_030110585.1  RING finger protein 32 isoform X3

    UniProtKB/TrEMBL
    F6URG7
    Conserved Domains (3) summary
    cd16677
    Location:54 → 97
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:220 → 287
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:116 → 135
    IQ; IQ calmodulin-binding motif

  15. XM_006535777.3 → XP_006535840.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_006535840.1

    UniProtKB/Swiss-Prot
    Q9D9X0, Q9DAJ3, Q9JIT1
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:294 → 361
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  16. XM_036165364.1 → XP_036021257.1  RING finger protein 32 isoform X2

    UniProtKB/TrEMBL
    F6URG7
    Related
    ENSMUSP00000123952.2, ENSMUST00000162975.2
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:238 → 305
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  17. XM_006535779.3 → XP_006535842.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_006535842.1

    UniProtKB/Swiss-Prot
    Q9D9X0, Q9DAJ3, Q9JIT1
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:294 → 361
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif

  18. XM_030254727.1 → XP_030110587.1  RING finger protein 32 isoform X4

    Conserved Domains (2) summary
    cd16678
    Location:128 → 195
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:24 → 43
    IQ; IQ calmodulin-binding motif

  19. XM_030254728.1 → XP_030110588.1  RING finger protein 32 isoform X4

    Conserved Domains (2) summary
    cd16678
    Location:128 → 195
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:24 → 43
    IQ; IQ calmodulin-binding motif

  20. XM_006535776.5 → XP_006535839.1  RING finger protein 32 isoform X1

    See identical proteins and their annotated locations for XP_006535839.1

    UniProtKB/Swiss-Prot
    Q9D9X0, Q9DAJ3, Q9JIT1
    Conserved Domains (3) summary
    cd16677
    Location:128 → 171
    RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    cd16678
    Location:294 → 361
    RING2-H2_RNF32; RING finger 2, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
    pfam00612
    Location:190 → 209
    IQ; IQ calmodulin-binding motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIT1.1 GenPept UniProtKB/Swiss-Prot:Q9JIT1

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