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Trpm5 transient receptor potential cation channel, subfamily M, member 5 [ Mus musculus (house mouse) ]

Gene ID: 56843, updated on 21-Apr-2024

Summary

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Official Symbol
Trpm5provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily M, member 5provided by MGI
Primary source
MGI:MGI:1861718
See related
Ensembl:ENSMUSG00000009246 AllianceGenome:MGI:1861718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mtr1; Ltrpc5; LTrpC-5; 9430099A16Rik
Summary
Enables calcium activated cation channel activity; potassium channel activity; and sodium channel activity. Acts upstream of or within ion transmembrane transport. Predicted to be located in dendrite and neuronal cell body. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including ganglia; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Orthologous to human TRPM5 (transient receptor potential cation channel subfamily M member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 15.6), small intestine adult (RPKM 3.2) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 88.11 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142625266..142648379, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143071529..143094642, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6616 Neighboring gene STARR-seq mESC enhancer starr_20520 Neighboring gene STARR-positive B cell enhancer ABC_E6617 Neighboring gene STARR-seq mESC enhancer starr_20521 Neighboring gene expressed sequence R74862 Neighboring gene nonconserved acetylation island sequence M93 enhancer Neighboring gene CD81 antigen Neighboring gene tumor-suppressing subchromosomal transferable fragment 4 Neighboring gene VISTA enhancer mm183 Neighboring gene STARR-seq mESC enhancer starr_20525 Neighboring gene potassium voltage-gated channel, subfamily Q, member 1 Neighboring gene predicted gene 28821 Neighboring gene KCNQ1 overlapping transcript 1 Neighboring gene STARR-positive B cell enhancer ABC_E10485

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice. Bos R, et al. Nat Commun, 2021 Nov 24. PMID 34819493, Free PMC Article
  2. Activation of the bitter taste sensor TRPM5 prevents high salt-induced cardiovascular dysfunction. Wu H, et al. Sci China Life Sci, 2020 Nov. PMID 32303962
  3. Impairment of Bitter Taste Sensor Transient Receptor Potential Channel M5-Mediated Aversion Aggravates High-Salt Intake and Hypertension. Cui Y, et al. Hypertension, 2019 Oct. PMID 31401881
  4. Ablation of TRPM5 in Mice Results in Reduced Body Weight Gain and Improved Glucose Tolerance and Protects from Excessive Consumption of Sweet Palatable Food when Fed High Caloric Diets. Larsson MH, et al. PLoS One, 2015. PMID 26397098, Free PMC Article
  5. Flavor preference conditioning by different sugars in sweet ageusic Trpm5 knockout mice. Sclafani A, et al. Physiol Behav, 2015 Mar 1. PMID 25497884, Free PMC Article

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.
    Title: Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.
  2. Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice.
    Title: Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice.
  3. Activation of the bitter taste sensor TRPM5 prevents high salt-induced cardiovascular dysfunction.
    Title: Activation of the bitter taste sensor TRPM5 prevents high salt-induced cardiovascular dysfunction.
  4. Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium.
    Title: Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium.
  5. TRPM5-expressing Microvillous Cells Regulate Region-specific Cell Proliferation and Apoptosis During Chemical Exposure.
    Title: TRPM5-expressing Microvillous Cells Regulate Region-specific Cell Proliferation and Apoptosis During Chemical Exposure.
  6. TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.
    Title: TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.
  7. TRPM5(-/-) mice showed a lowered aversion to high-salt diet and developed salt-induced hypertension.
    Title: Impairment of Bitter Taste Sensor Transient Receptor Potential Channel M5-Mediated Aversion Aggravates High-Salt Intake and Hypertension.
  8. Both TRPM4 and TRPM5 are required for normal responses to bitter, sweet, and umami stimuli.
    Title: TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells.
  9. This physiological and behavioral results indicate that TRPM5-MCs play a protective role in maintaining the olfactory function of the mammalian main olfactory epithelium.
    Title: Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment.
  10. conclude that nAChR subunits are expressed in Trpm5-positive TRCs and their expression levels are differentially altered by chronic oral exposure to nicotine and ethanol
    Title: Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs).
Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-activated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligand-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel subfamily M member 5
Names
MLSN1- and TRP-related gene 1 protein
long transient receptor potential channel 5
long transient receptor potential-related channel 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020277.2 → NP_064673.2  transient receptor potential cation channel subfamily M member 5

    See identical proteins and their annotated locations for NP_064673.2

    Status: VALIDATED

    Source sequence(s)
    AB039952, AF228681, AK044908
    Consensus CDS
    CCDS52462.1
    UniProtKB/Swiss-Prot
    A3KN89, Q3TU14, Q7TPL4, Q99NF9, Q9EPM3, Q9EPM4, Q9JJH7
    UniProtKB/TrEMBL
    Q8BS44
    Related
    ENSMUSP00000009390.4, ENSMUST00000009390.10
    Conserved Domains (2) summary
    TIGR00870
    Location:711 → 1022
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:49 → 267
    LSDAT_euk; SLOG in TRPM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142625266..142648379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508645.1 → XP_006508708.1  transient receptor potential cation channel subfamily M member 5 isoform X1

    See identical proteins and their annotated locations for XP_006508708.1

    UniProtKB/Swiss-Prot
    A3KN89, Q3TU14, Q7TPL4, Q99NF9, Q9EPM3, Q9EPM4, Q9JJH7
    UniProtKB/TrEMBL
    Q8BS44
    Conserved Domains (2) summary
    TIGR00870
    Location:711 → 1022
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:49 → 267
    LSDAT_euk; SLOG in TRPM

  2. XM_030242820.1 → XP_030098680.1  transient receptor potential cation channel subfamily M member 5 isoform X3

    Related
    ENSMUST00000150589.8
    Conserved Domains (1) summary
    TIGR00870
    Location:325 → 636
    trp; transient-receptor-potential calcium channel protein

  3. XM_006508646.4 → XP_006508709.1  transient receptor potential cation channel subfamily M member 5 isoform X2

    See identical proteins and their annotated locations for XP_006508709.1

    UniProtKB/TrEMBL
    Q8BS44
    Related
    ENSMUSP00000114302.2, ENSMUST00000150867.2
    Conserved Domains (2) summary
    pfam00520
    Location:741 → 872
    Ion_trans; Ion transport protein
    cl39032
    Location:49 → 267
    LSDAT_euk; SLOG in TRPM

RNA

  1. XR_003946530.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJH7.1 GenPept UniProtKB/Swiss-Prot:Q9JJH7

Gene LinkOut

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