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SLAMF8 SLAM family member 8 [ Homo sapiens (human) ]

Gene ID: 56833, updated on 5-Mar-2024

Summary

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Official Symbol
SLAMF8provided by HGNC
Official Full Name
SLAM family member 8provided by HGNC
Primary source
HGNC:HGNC:21391
See related
Ensembl:ENSG00000158714 MIM:606620; AllianceGenome:HGNC:21391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BLAME; CD353; SBBI42
Summary
This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 13.5), lymph node (RPKM 12.8) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See SLAMF8 in Genome Data Viewer
Location:
1q23.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159826873..159837492)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158963866..158974492)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159796663..159807282)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:159751068-159751644 Neighboring gene dual specificity phosphatase 23 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9322 Neighboring gene Sharpr-MPRA regulatory region 9392 Neighboring gene uncharacterized LOC105371464 Neighboring gene Fc receptor like 6 Neighboring gene small nucleolar RNA host gene 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159815652-159816152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159816153-159816653 Neighboring gene small nucleolar RNA SNORD64 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1455 Neighboring gene uncharacterized LOC107985216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159830948-159831862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159831863-159832775 Neighboring gene V-set and immunoglobulin domain containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SLAMF8 promotes the proliferation and migration of synovial fibroblasts by regulating the ERK/MMPs signalling pathway. Liu J, et al. Autoimmunity, 2022 Aug. PMID 35506438
  2. SLAM family member 8 is expressed in and enhances the growth of anaplastic large cell lymphoma. Sugimoto A, et al. Sci Rep, 2020 Feb 13. PMID 32054954, Free PMC Article
  3. SLAMF8 Participates in Acute Renal Transplant Rejection via TLR4 Pathway on Pro-Inflammatory Macrophages. Teng L, et al. Front Immunol, 2022. PMID 35432371, Free PMC Article
  4. Knockout of SLAMF8 attenuates collagen-induced rheumatoid arthritis in mice through inhibiting TLR4/NF-κB signaling pathway. Qin W, et al. Int Immunopharmacol, 2022 Jun. PMID 35259711
  5. SLAM family member 8 is involved in oncogenic KIT-mediated signalling in human mastocytosis. Sugimoto A, et al. Exp Dermatol, 2018 Jun. PMID 29498772

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of SLAMF8 aggravates ischemia/reperfusion-induced ferroptosis and injury in cardiomyocyte.
    Title: Upregulation of SLAMF8 aggravates ischemia/reperfusion-induced ferroptosis and injury in cardiomyocyte.
  2. SLAMF8 promotes the proliferation and migration of synovial fibroblasts by regulating the ERK/MMPs signalling pathway.
    Title: SLAMF8 promotes the proliferation and migration of synovial fibroblasts by regulating the ERK/MMPs signalling pathway.
  3. Knockout of SLAMF8 attenuates collagen-induced rheumatoid arthritis in mice through inhibiting TLR4/NF-kappaB signaling pathway.
    Title: Knockout of SLAMF8 attenuates collagen-induced rheumatoid arthritis in mice through inhibiting TLR4/NF-κB signaling pathway.
  4. SLAMF8 Participates in Acute Renal Transplant Rejection via TLR4 Pathway on Pro-Inflammatory Macrophages.
    Title: SLAMF8 Participates in Acute Renal Transplant Rejection via TLR4 Pathway on Pro-Inflammatory Macrophages.
  5. SLAM family member 8 is expressed in and enhances the growth of anaplastic large cell lymphoma.
    Title: SLAM family member 8 is expressed in and enhances the growth of anaplastic large cell lymphoma.
  6. Thus, SLAMF8 is involved in oncogenic KIT-mediated RAS-RAF- ERK signalling and the subsequent growth of human neoplastic mast cells mediated by SHP-2.
    Title: SLAM family member 8 is involved in oncogenic KIT-mediated signalling in human mastocytosis.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20442, MGC129578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in B-1 B cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in leukocyte chemotaxis involved in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within leukocyte chemotaxis involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of dendritic cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of macrophage chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of monocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of neutrophil migration ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of respiratory burst involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within phagosome acidification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within regulation of NAD(P)H oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell surface NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SLAM family member 8
Names
B lymphocyte activator macrophage expressed
BCM-like membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330741.2 → NP_001317670.1  SLAM family member 8 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL590560
    Consensus CDS
    CCDS81387.1
    UniProtKB/Swiss-Prot
    Q9P0V8
    Related
    ENSP00000357084.4, ENST00000368104.4

  2. NM_020125.3 → NP_064510.1  SLAM family member 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_064510.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF146761
    Consensus CDS
    CCDS1188.1
    UniProtKB/Swiss-Prot
    Q32MC6, Q5VU15, Q9P0V8
    Related
    ENSP00000289707.5, ENST00000289707.10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    159826873..159837492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001845.3 → XP_016857334.1  SLAM family member 8 isoform X6

  2. XM_011509775.3 → XP_011508077.1  SLAM family member 8 isoform X1

  3. XM_005245345.4 → XP_005245402.1  SLAM family member 8 isoform X3

  4. XM_011509776.3 → XP_011508078.1  SLAM family member 8 isoform X2

  5. XM_017001846.2 → XP_016857335.1  SLAM family member 8 isoform X7

  6. XM_011509778.3 → XP_011508080.1  SLAM family member 8 isoform X5

  7. XM_011509779.3 → XP_011508081.1  SLAM family member 8 isoform X8

  8. XM_011509777.4 → XP_011508079.1  SLAM family member 8 isoform X4

  9. XM_017001844.3 → XP_016857333.1  SLAM family member 8 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    158963866..158974492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337742.1 → XP_054193717.1  SLAM family member 8 isoform X1

  2. XM_054337744.1 → XP_054193719.1  SLAM family member 8 isoform X3

  3. XM_054337743.1 → XP_054193718.1  SLAM family member 8 isoform X2

  4. XM_054337747.1 → XP_054193722.1  SLAM family member 8 isoform X5

  5. XM_054337750.1 → XP_054193725.1  SLAM family member 8 isoform X8

  6. XM_054337748.1 → XP_054193723.1  SLAM family member 8 isoform X6

  7. XM_054337749.1 → XP_054193724.1  SLAM family member 8 isoform X7

  8. XM_054337745.1 → XP_054193720.1  SLAM family member 8 isoform X4

  9. XM_054337746.1 → XP_054193721.1  SLAM family member 8 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P0V8.1 GenPept UniProtKB/Swiss-Prot:Q9P0V8

Gene LinkOut

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