Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnajb2provided by MGI
Official Full Name: DnaJ heat shock protein family (Hsp40) member B2provided by MGI
Primary source: MGI:MGI:1928739
See related: Ensembl:ENSMUSG00000026203 AllianceGenome:MGI:1928739
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hsj1; mDj8; Dnajb10; 2700059H22Rik
Summary: Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and modification-dependent protein binding activity. Predicted to be involved in several processes, including positive regulation of ATPase activity; protein refolding; and regulation of cellular protein metabolic process. Predicted to be located in inclusion body; nuclear membrane; and perinuclear region of cytoplasm. Predicted to be part of proteasome complex. Predicted to be active in cytosol. Predicted to be intrinsic component of endoplasmic reticulum membrane. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Human ortholog(s) of this gene implicated in distal spinal muscular atrophy type 5. Orthologous to human DNAJB2 (DnaJ heat shock protein family (Hsp40) member B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 63.8), cerebellum adult (RPKM 25.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C4; 1 38.64 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (75213039..75222336)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (75236395..75245692)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsc70, Hdj1 and Hdj2 interact with soluble and fibrillar alpha-synuclein
Title: Hsc70 protein interaction with soluble and fibrillar alpha-synuclein.
Data show that DNAJB2 is expressed in skeletal muscle at the neuromuscular junction of normal fibers, in the cytoplasm and membrane of regenerating fibers, and in protein aggregates and vacuoles in protein aggregate myopathies.
Title: DNAJB2 expression in normal and diseased human and mouse skeletal muscle.
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
Title: Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-modified protein reader activity	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inclusion body assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	ISO Inferred from Sequence Orthology more info
involved_in regulation of chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dnaJ homolog subfamily B member 2

Names: DnaJ (Hsp40) homolog, subfamily B, member 10; DnaJ (Hsp40) homolog, subfamily B, member 2; dnaJ homolog subfamily B member 10; heat shock protein, DNAJ-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159883.1 → NP_001153355.1 dnaJ homolog subfamily B member 2 isoform 3

See identical proteins and their annotated locations for NP_001153355.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AK171494, BF467509, BY073498

Consensus CDS

CCDS78622.1

UniProtKB/Swiss-Prot

Q3TB24, Q8BPF6, Q921S2, Q9QYI5

Related

ENSMUSP00000140566.2, ENSMUST00000188931.7

Conserved Domains (1) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
NM_001159884.1 → NP_001153356.1 dnaJ homolog subfamily B member 2 isoform 2

See identical proteins and their annotated locations for NP_001153356.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2, 4, and 5 all encode isoform 2.

Source sequence(s)

AK076061, BF467509, BY073498, BY092620

Consensus CDS

CCDS35624.1

UniProtKB/Swiss-Prot

Q9QYI5

Related

ENSMUSP00000140588.2, ENSMUST00000188346.7

Conserved Domains (3) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

pfam00226
Location:3 → 66

DnaJ; DnaJ domain

pfam02809
Location:250 → 266

UIM; Ubiquitin interaction motif
NM_001159885.1 → NP_001153357.1 dnaJ homolog subfamily B member 2 isoform 2

See identical proteins and their annotated locations for NP_001153357.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2, 4, and 5 all encode isoform 2.

Source sequence(s)

AK076061, BF467509, CJ174452

Consensus CDS

CCDS35624.1

UniProtKB/Swiss-Prot

Q9QYI5

Related

ENSMUSP00000080796.7, ENSMUST00000082158.13

Conserved Domains (3) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

pfam00226
Location:3 → 66

DnaJ; DnaJ domain

pfam02809
Location:250 → 266

UIM; Ubiquitin interaction motif
NM_020266.2 → NP_064662.2 dnaJ homolog subfamily B member 2 isoform 1

See identical proteins and their annotated locations for NP_064662.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (1) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform 3.

Source sequence(s)

AB028858, AK076061, BF467509, BY073498

Consensus CDS

CCDS15068.1

UniProtKB/Swiss-Prot

Q9QYI5

Related

ENSMUSP00000140637.2, ENSMUST00000187058.7

Conserved Domains (1) summary

COG0484
Location:3 → 92

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
NM_178055.4 → NP_835156.1 dnaJ homolog subfamily B member 2 isoform 2

See identical proteins and their annotated locations for NP_835156.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2, 4, and 5 all encode isoform 2.

Source sequence(s)

AK076061, BF467509, BY073498

Consensus CDS

CCDS35624.1

UniProtKB/Swiss-Prot

Q9QYI5

Related

ENSMUSP00000140634.2, ENSMUST00000188290.7

Conserved Domains (3) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

pfam00226
Location:3 → 66

DnaJ; DnaJ domain

pfam02809
Location:250 → 266

UIM; Ubiquitin interaction motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

75213039..75222336

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152498.1 → XP_036008391.1 dnaJ homolog subfamily B member 2 isoform X1

Conserved Domains (2) summary

smart00726
Location:291 → 310

UIM; Ubiquitin-interacting motif

PRK14294
Location:102 → 151

PRK14294; chaperone protein DnaJ; Provisional
XM_036152499.1 → XP_036008392.1 dnaJ homolog subfamily B member 2 isoform X2

Conserved Domains (2) summary

smart00726
Location:291 → 310

UIM; Ubiquitin-interacting motif

PRK14294
Location:102 → 151

PRK14294; chaperone protein DnaJ; Provisional
XM_036152500.1 → XP_036008393.1 dnaJ homolog subfamily B member 2 isoform X3

Conserved Domains (2) summary

smart00726
Location:291 → 310

UIM; Ubiquitin-interacting motif

PRK14294
Location:102 → 151

PRK14294; chaperone protein DnaJ; Provisional
XM_036152501.1 → XP_036008394.1 dnaJ homolog subfamily B member 2 isoform X5

Conserved Domains (1) summary

COG0484
Location:3 → 92

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
XM_036152502.1 → XP_036008395.1 dnaJ homolog subfamily B member 2 isoform X6

Related

ENSMUSP00000052520.8, ENSMUST00000055223.14

Conserved Domains (1) summary

COG0484
Location:3 → 92

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
XM_006496511.2 → XP_006496574.1 dnaJ homolog subfamily B member 2 isoform X4

Conserved Domains (2) summary

COG0484
Location:3 → 110

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

pfam02809
Location:250 → 266

UIM; Ubiquitin interaction motif