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Gmeb1 glucocorticoid modulatory element binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 56809, updated on 5-Mar-2024

Summary

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Official Symbol
Gmeb1provided by MGI
Official Full Name
glucocorticoid modulatory element binding protein 1provided by MGI
Primary source
MGI:MGI:2135604
See related
Ensembl:ENSMUSG00000028901 AllianceGenome:MGI:2135604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110050A04Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; limb; and sensory organ. Orthologous to human GMEB1 (glucocorticoid modulatory element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.7), CNS E14 (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gmeb1 in Genome Data Viewer
Location:
4 D2.3; 4 64.99 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131948336..131988919, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132221025..132261609, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene YTH N6-methyladenosine RNA binding protein 2 Neighboring gene ribosomal protein S15A, pseudogene 4 Neighboring gene cytochrome c-like Neighboring gene predicted gene 28874 Neighboring gene STARR-positive B cell enhancer ABC_E3519 Neighboring gene U11 small nuclear RNA Neighboring gene TATA-box binding protein associated factor 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function. Tuesta LM, et al. Nat Commun, 2019 Jun 7. PMID 31175277, Free PMC Article
  2. A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions. Maitra R, et al. Nucleic Acids Res, 2009 Jun. PMID 19324890, Free PMC Article
  3. Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury. Tsuruma K, et al. J Biol Chem, 2006 Apr 21. PMID 16497673
  4. Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family. Jimenez-Lara AM, et al. FEBS Lett, 2000 Feb 25. PMID 10692587
  5. Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles. L'Hôte D, et al. Hum Mol Genet, 2012 Jul 15. PMID 22544055

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gmeb1 knockdown in midbrain dopamine (mDA) neurons resulted in downregulation of tyrosine hydroxylase and dopamine transporter, as well as in severe motor deficits. This study thus identifies Gmeb1 as a master regulator of mDA gene expression and function.
    Title: In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function.
  2. GMEB1 is an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis
    Title: Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glucocorticoid modulatory element-binding protein 1
Names
GMEB-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122992.1 → NP_001116464.1  glucocorticoid modulatory element-binding protein 1

    See identical proteins and their annotated locations for NP_001116464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK134349, BU701415, BX537301, BY732360, DV660282
    Consensus CDS
    CCDS18720.1
    UniProtKB/Swiss-Prot
    Q80Y88, Q9JL60
    UniProtKB/TrEMBL
    Q3UYV4
    Related
    ENSMUSP00000101585.2, ENSMUST00000105965.8
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

  2. NM_020273.2 → NP_064669.2  glucocorticoid modulatory element-binding protein 1

    See identical proteins and their annotated locations for NP_064669.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AK134349, BU701415, BX537301, CN459906
    Consensus CDS
    CCDS18720.1
    UniProtKB/Swiss-Prot
    Q80Y88, Q9JL60
    UniProtKB/TrEMBL
    Q3UYV4
    Related
    ENSMUSP00000101584.2, ENSMUST00000105964.2
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    131948336..131988919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164279.1 → XP_036020172.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3UYV4
    Conserved Domains (1) summary
    pfam01342
    Location:1 → 75
    SAND; SAND domain

  2. XM_006539080.5 → XP_006539143.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006539143.1

    UniProtKB/Swiss-Prot
    Q80Y88, Q9JL60
    UniProtKB/TrEMBL
    Q3UYV4
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

  3. XM_036164277.1 → XP_036020170.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q80Y88, Q9JL60
    UniProtKB/TrEMBL
    Q3UYV4
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

  4. XM_036164280.1 → XP_036020173.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3UYV4
    Conserved Domains (1) summary
    pfam01342
    Location:1 → 75
    SAND; SAND domain

  5. XM_006539079.5 → XP_006539142.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006539142.1

    UniProtKB/Swiss-Prot
    Q80Y88, Q9JL60
    UniProtKB/TrEMBL
    Q3UYV4
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

  6. XM_017320332.3 → XP_017175821.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q80Y88, Q9JL60
    UniProtKB/TrEMBL
    Q3UYV4
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

  7. XM_036164278.1 → XP_036020171.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3UYV4
    Conserved Domains (1) summary
    pfam01342
    Location:1 → 75
    SAND; SAND domain

  8. XM_036164275.1 → XP_036020168.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q80Y88, Q9JL60
    UniProtKB/TrEMBL
    Q3UYV4
    Related
    ENSMUSP00000131331.2, ENSMUST00000168553.8
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

  9. XM_036164274.1 → XP_036020167.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q80Y88, Q9JL60
    UniProtKB/TrEMBL
    Q3UYV4
    Related
    ENSMUSP00000030733.3, ENSMUST00000030733.9
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

  10. XM_006539078.4 → XP_006539141.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006539141.1

    UniProtKB/Swiss-Prot
    Q80Y88, Q9JL60
    UniProtKB/TrEMBL
    Q3UYV4
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL60.2 GenPept UniProtKB/Swiss-Prot:Q9JL60

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