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PSG11 pregnancy specific beta-1-glycoprotein 11 [ Homo sapiens (human) ]

Gene ID: 5680, updated on 8-Mar-2024

Summary

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Official Symbol
PSG11provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 11provided by HGNC
Primary source
HGNC:HGNC:9516
See related
Ensembl:ENSG00000243130 MIM:176401; AllianceGenome:HGNC:9516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSG13; PSG14; PSBG-11; PSBG-13
Summary
The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Expression
Restricted expression toward placenta (RPKM 77.7) See more
Orthologs
all
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Genomic context

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See PSG11 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43007656..43026469, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45828237..45847052, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43511808..43530621, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 7 Neighboring gene CEA cell adhesion molecule pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:43497577-43497773 Neighboring gene CEA cell adhesion molecule pseudogene 8 Neighboring gene pregnancy specific beta-1-glycoprotein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients. Zhao L, et al. BMC Pregnancy Childbirth, 2012 Jun 29. PMID 22748001, Free PMC Article
  2. Cloning and expression of a new pregnancy-specific beta 1-glycoprotein member. Plouzek CA, et al. Biochem Biophys Res Commun, 1991 May 15. PMID 1840485
  3. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. Teglund S, et al. Biochem Biophys Res Commun, 1995 Jun 15. PMID 7794280
  4. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. Thompson J, et al. Biochem Biophys Res Commun, 1990 Mar 16. PMID 1690992
  5. Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700-kb cosmid contig spanning the region. Olsen A, et al. Genomics, 1994 Oct. PMID 7851895

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. recurrent deletions that may confer risk for preeclampsia include a potentially functionally important copy-number deletion in the PSG11 gene.
    Title: Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: PSG6

Homology

Clone Names

  • MGC22484

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in female pregnancy TAS
Traceable Author Statement
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pregnancy-specific beta-1-glycoprotein 11
Names
PS-beta-G-11
PS-beta-G-13
pregnancy-specific beta-1-glycoprotein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113410.2 → NP_001106881.1  pregnancy-specific beta-1-glycoprotein 11 isoform 2

    See identical proteins and their annotated locations for NP_001106881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC005947, BC020711, BE767872, R66665
    Consensus CDS
    CCDS12615.2
    Related
    ENSP00000385427.1, ENST00000403486.5
    Conserved Domains (3) summary
    smart00410
    Location:124 → 196
    IG_like; Immunoglobulin like
    pfam13895
    Location:120 → 198
    Ig_2; Immunoglobulin domain
    cl11960
    Location:26 → 114
    Ig; Immunoglobulin domain

  2. NM_002785.3 → NP_002776.3  pregnancy-specific beta-1-glycoprotein 11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002776.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC005947, BC020711, BE767872, BF084984, BG619770, R66665
    Consensus CDS
    CCDS12614.2
    UniProtKB/Swiss-Prot
    Q13179, Q15242, Q8WW91, Q9UNE4, Q9UQ72
    UniProtKB/TrEMBL
    A0A0F7CSH9
    Related
    ENSP00000319140.7, ENST00000320078.12
    Conserved Domains (3) summary
    cd05740
    Location:148 → 236
    IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains
    cd05774
    Location:36 → 138
    IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd20948
    Location:246 → 320
    IgC2_CEACAM5-like; Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains

  3. NM_203287.2 → NP_976032.2  pregnancy-specific beta-1-glycoprotein 11 isoform 2

    See identical proteins and their annotated locations for NP_976032.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC005947, BC020711, R66665
    Consensus CDS
    CCDS12615.2
    Related
    ENSP00000304913.6, ENST00000306322.7
    Conserved Domains (3) summary
    smart00410
    Location:124 → 196
    IG_like; Immunoglobulin like
    pfam13895
    Location:120 → 198
    Ig_2; Immunoglobulin domain
    cl11960
    Location:26 → 114
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43007656..43026469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45828237..45847052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UQ72.3 GenPept UniProtKB/Swiss-Prot:Q9UQ72

Gene LinkOut

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