Stap1 signal transducing adaptor family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stap1provided by MGI
Official Full Name: signal transducing adaptor family member 1provided by MGI
Primary source: MGI:MGI:1926193
See related: Ensembl:ENSMUSG00000029254 AllianceGenome:MGI:1926193
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brdg1; STAP-1
Summary: Enables macrophage colony-stimulating factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including negative regulation of macrophage colony-stimulating factor signaling pathway; negative regulation of macrophage migration; and positive regulation of cellular component organization. Acts upstream of or within response to bacterium and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human STAP1 (signal transducing adaptor family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (86219446..86251859)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (86071584..86106125)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma.
Title: Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma.
Mice lacking global Stap1 expression do not manifest hypercholesterolemia.
Title: Mice lacking global Stap1 expression do not manifest hypercholesterolemia.
Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells.
Title: Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells.
Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML.
Title: Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML.
Our combined studies in mouse models and carriers of STAP1 variants indicate that STAP1 is not a familial hypercholesterolemia gene.
Title: Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans.
Taken together, this study implicates a previously unknown role of STAP-1 in pro-inflammatory microglia activation potentially contributing to neuronal apoptosis and degeneration.
Title: Induction of STAP-1 promotes neurotoxic activation of microglia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables macrophage colony-stimulating factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage colony-stimulating factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microglial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ruffle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of microglial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microglial cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: signal-transducing adaptor protein 1

Names: BCR downstream signaling 1; stem cell adaptor protein STAP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310639.1 → NP_001297568.1 signal-transducing adaptor protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK041474, AK162655, BF660908

Consensus CDS

CCDS80312.1

UniProtKB/TrEMBL

A0A0H2UKC0, B7ZP01

Related

ENSMUSP00000031171.9, ENSMUST00000031171.9

Conserved Domains (2) summary

cd10403
Location:140 → 233

SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)

cl17171
Location:15 → 101

PH-like; Pleckstrin homology-like domain
NM_001425532.1 → NP_001412461.1 signal-transducing adaptor protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC107634
NM_019992.4 → NP_064376.1 signal-transducing adaptor protein 1 isoform 1

See identical proteins and their annotated locations for NP_064376.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK041474, AK162655, BF660908

Consensus CDS

CCDS19377.1

UniProtKB/Swiss-Prot

A6H6C6, Q3TRM1, Q6PES6, Q9JM90

UniProtKB/TrEMBL

B7ZP01

Related

ENSMUSP00000143251.2, ENSMUST00000198435.5

Conserved Domains (3) summary

cd10403
Location:178 → 271

SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)

pfam00169
Location:26 → 112

PH; PH domain

cl17171
Location:15 → 139

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

86219446..86251859

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165360.1 → XP_036021253.1 signal-transducing adaptor protein 1 isoform X2

Conserved Domains (1) summary

cl17171
Location:15 → 121

PH-like; Pleckstrin homology-like domain