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Supt20 SPT20 SAGA complex component [ Mus musculus (house mouse) ]

Gene ID: 56790, updated on 11-Apr-2024

Summary

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Official Symbol
Supt20provided by MGI
Official Full Name
SPT20 SAGA complex componentprovided by MGI
Primary source
MGI:MGI:1929651
See related
Ensembl:ENSMUSG00000027751 AllianceGenome:MGI:1929651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p38IP; Fam48a; Supt20h; D3Ertd300e
Summary
Predicted to enable transcription coregulator activity. Acts upstream of or within positive regulation of gluconeogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be part of SAGA complex. Is expressed in foregut-midgut junction; hindgut; midgut; rectum; and stomach. Orthologous to several human genes including SUPT20H (SPT20 homolog, SAGA complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 74.7), limb E14.5 (RPKM 29.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 C; 3 25.59 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (54600181..54636184)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (54692760..54728763)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:54393991-54394215 Neighboring gene predicted gene, 40050 Neighboring gene REX1, RNA exonuclease 1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_07679 Neighboring gene STARR-positive B cell enhancer ABC_E8986 Neighboring gene STARR-seq mESC enhancer starr_07681 Neighboring gene STARR-positive B cell enhancer ABC_E7912 Neighboring gene STARR-positive B cell enhancer ABC_E10181 Neighboring gene exosome component 8 Neighboring gene ALG5 dolichyl-phosphate beta-glucosyltransferase Neighboring gene SMAD family member 9 Neighboring gene STARR-seq mESC enhancer starr_07686

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5. Liu X, et al. J Biol Chem, 2013 Dec 20. PMID 24220028, Free PMC Article
  2. Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification. Clements M, et al. Curr Biol, 2011 Aug 9. PMID 21802298, Free PMC Article
  3. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. Ravnskjaer K, et al. J Clin Invest, 2013 Oct. PMID 24051374, Free PMC Article
  4. Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation. Jin JZ, et al. Dev Biol, 2013 Sep 1. PMID 23747598, Free PMC Article
  5. Supt20 is required for development of the axial skeleton. Warrier S, et al. Dev Biol, 2017 Jan 15. PMID 27894818, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within gastrulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gluconeogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SAGA-type complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription factor SPT20 homolog
Names
family with sequence similarity 48, member A
p38-interacting protein
protein FAM48A
suppressor of Ty 20
transcription factor (p38 interacting protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358015.2 → NP_001344944.1  transcription factor SPT20 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC100927
    Conserved Domains (2) summary
    pfam05109
    Location:480 → 769
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12090
    Location:77 → 217
    Spt20; Spt20 family

  2. NM_001358017.2 → NP_001344946.1  transcription factor SPT20 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC100927
    Conserved Domains (2) summary
    pfam05109
    Location:479 → 768
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12090
    Location:76 → 216
    Spt20; Spt20 family

  3. NM_001407763.1 → NP_001394692.1  transcription factor SPT20 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC100927

  4. NM_001407764.1 → NP_001394693.1  transcription factor SPT20 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC100927

  5. NM_001407765.1 → NP_001394694.1  transcription factor SPT20 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC100927

  6. NM_001407766.1 → NP_001394695.1  transcription factor SPT20 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC100927

  7. NM_001407767.1 → NP_001394696.1  transcription factor SPT20 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC100927

  8. NM_001407768.1 → NP_001394697.1  transcription factor SPT20 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC100927

  9. NM_001407769.1 → NP_001394698.1  transcription factor SPT20 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC100927

  10. NM_001407770.1 → NP_001394699.1  transcription factor SPT20 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC100927

  11. NM_001407771.1 → NP_001394700.1  transcription factor SPT20 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC100927

  12. NM_001407772.1 → NP_001394701.1  transcription factor SPT20 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC100927

  13. NM_001407773.1 → NP_001394702.1  transcription factor SPT20 homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC100927

  14. NM_001407774.1 → NP_001394703.1  transcription factor SPT20 homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC100927

  15. NM_001407775.1 → NP_001394704.1  transcription factor SPT20 homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC100927
    UniProtKB/TrEMBL
    A0A0G2JGY6

  16. NM_001407776.1 → NP_001394705.1  transcription factor SPT20 homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC100927
    UniProtKB/TrEMBL
    A0A0G2JGY6

  17. NM_001407777.1 → NP_001394706.1  transcription factor SPT20 homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC100927
    UniProtKB/TrEMBL
    A0A0G2JGY6
    Related
    ENSMUSP00000143750.2, ENSMUST00000197502.5

  18. NM_001407778.1 → NP_001394707.1  transcription factor SPT20 homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC100927

  19. NM_001407779.1 → NP_001394708.1  transcription factor SPT20 homolog isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC100927

  20. NM_001407780.1 → NP_001394709.1  transcription factor SPT20 homolog isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC100927

  21. NM_001407781.1 → NP_001394710.1  transcription factor SPT20 homolog isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC100927

  22. NM_001407782.1 → NP_001394711.1  transcription factor SPT20 homolog isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC100927
    UniProtKB/Swiss-Prot
    Q7TT00, Q8BG53, Q9JLS9
    Related
    ENSMUSP00000143059.2, ENSMUST00000200439.2

  23. NM_001407783.1 → NP_001394712.1  transcription factor SPT20 homolog isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC100927
    UniProtKB/Swiss-Prot
    Q7TT00, Q8BG53, Q9JLS9

  24. NM_001407784.1 → NP_001394713.1  transcription factor SPT20 homolog isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC100927

  25. NM_001407785.1 → NP_001394714.1  transcription factor SPT20 homolog isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC100927
    UniProtKB/TrEMBL
    A0A0G2JEY3
    Related
    ENSMUSP00000142948.2, ENSMUST00000199674.5

  26. NM_019995.5 → NP_064379.1  transcription factor SPT20 homolog isoform 3

    See identical proteins and their annotated locations for NP_064379.1

    Status: VALIDATED

    Source sequence(s)
    AC100927
    Consensus CDS
    CCDS38431.1
    UniProtKB/Swiss-Prot
    Q7TT00
    Related
    ENSMUSP00000131454.2, ENSMUST00000170552.6
    Conserved Domains (1) summary
    pfam12090
    Location:64 → 226
    Spt20; Spt20 family

RNA

  1. NR_152184.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC100927

  2. NR_152185.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC100927

  3. NR_152186.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC100927

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    54600181..54636184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501812.1 → XP_006501875.1  transcription factor SPT20 homolog isoform X6

    Conserved Domains (2) summary
    pfam05109
    Location:480 → 757
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12090
    Location:77 → 217
    Spt20; Spt20 family

  2. XM_036163195.1 → XP_036019088.1  transcription factor SPT20 homolog isoform X14

    Conserved Domains (1) summary
    pfam12090
    Location:8 → 148
    Spt20; Spt20 family

  3. XM_006501808.2 → XP_006501871.1  transcription factor SPT20 homolog isoform X3

    Conserved Domains (2) summary
    pfam05109
    Location:479 → 768
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12090
    Location:77 → 217
    Spt20; Spt20 family

  4. XM_030252731.1 → XP_030108591.1  transcription factor SPT20 homolog isoform X8

    Conserved Domains (2) summary
    pfam05109
    Location:411 → 700
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12090
    Location:8 → 148
    Spt20; Spt20 family

  5. XM_030252732.1 → XP_030108592.1  transcription factor SPT20 homolog isoform X9

    Conserved Domains (2) summary
    pfam05109
    Location:410 → 699
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12090
    Location:8 → 148
    Spt20; Spt20 family

  6. XM_006501813.2 → XP_006501876.1  transcription factor SPT20 homolog isoform X8

    Conserved Domains (2) summary
    pfam05109
    Location:411 → 700
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12090
    Location:8 → 148
    Spt20; Spt20 family

  7. XM_006501803.3 → XP_006501866.1  transcription factor SPT20 homolog isoform X1

    See identical proteins and their annotated locations for XP_006501866.1

    Conserved Domains (2) summary
    pfam05109
    Location:480 → 769
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12090
    Location:77 → 217
    Spt20; Spt20 family

RNA

  1. XR_004941374.1 RNA Sequence

  2. XR_003954365.2 RNA Sequence

  3. XR_001783729.2 RNA Sequence

  4. XR_004941369.1 RNA Sequence

  5. XR_004941371.1 RNA Sequence

  6. XR_375560.4 RNA Sequence

  7. XR_001783730.2 RNA Sequence

  8. XR_003954366.1 RNA Sequence

  9. XR_004941373.1 RNA Sequence

  10. XR_003954363.1 RNA Sequence

  11. XR_003954364.1 RNA Sequence

  12. XR_004941370.1 RNA Sequence

  13. XR_004941372.1 RNA Sequence

  14. XR_003954367.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT00.1 GenPept UniProtKB/Swiss-Prot:Q7TT00

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