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Mllt11 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 [ Mus musculus (house mouse) ]

Gene ID: 56772, updated on 5-Mar-2024

Summary

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Official Symbol
Mllt11provided by MGI
Official Full Name
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11provided by MGI
Primary source
MGI:MGI:1929671
See related
Ensembl:ENSMUSG00000053192 AllianceGenome:MGI:1929671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Af1q; Zfp692
Summary
Predicted to be involved in several processes, including apoptotic signaling pathway; positive regulation of mitochondrial depolarization; and positive regulation of release of cytochrome c from mitochondria. Located in cytoplasm. Is expressed in several structures, including gut; liver; nervous system; secondary oocyte; and sensory organ. Orthologous to human MLLT11 (MLLT11 transcription factor 7 cofactor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 117.9), whole brain E14.5 (RPKM 86.7) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 40.74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95125852..95139486, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95218544..95229632, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C Neighboring gene GA repeat binding protein, beta 2 Neighboring gene STARR-seq mESC enhancer starr_08372 Neighboring gene predicted gene, 16740 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells. Lin HJ, et al. Brain Res Mol Brain Res, 2004 Nov 24. PMID 15530661
  2. AF1q Contributes to Adriamycin-Induced Podocyte Injury by Activating Wnt/β-Catenin Signaling. Zhang H, et al. Kidney Blood Press Res, 2017. PMID 29069662
  3. MLLT11/AF1q is differentially expressed in maturing neurons during development. Yamada M, et al. Gene Expr Patterns, 2014 Jul. PMID 24839873
  4. Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal-interacting protein Mllt11. Blommers M, et al. Dev Dyn, 2023 Feb. PMID 36131367
  5. Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Stumpo DJ, et al. Blood, 2009 Sep 17. PMID 19633199, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal-interacting protein Mllt11.
    Title: Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal-interacting protein Mllt11.
  2. Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development.
    Title: Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development.
  3. aberrant expression of AF1q may activate Wnt/beta-catenin signaling and result in podocyte injury
    Title: AF1q Contributes to Adriamycin-Induced Podocyte Injury by Activating Wnt/β-Catenin Signaling.
  4. MLLT11 is a pan-neuronal marker, suggesting a role in neural differentiation in the central nervous system and neural crest-cell derived peripheral ganglia
    Title: MLLT11/AF1q is differentially expressed in maturing neurons during development.
  5. The mouse Af1q, homologue of human AF1q, was found to be significantly up-regulated during the neuronal production from neural stem cells
    Title: AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial depolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of release of cytochrome c from mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein AF1q
Names
ALL1-fused gene from chromosome 1q
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
zinc finger protein 692

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411090.1 → NP_001398019.1  protein AF1q

    Status: VALIDATED

    Source sequence(s)
    AC140190
    UniProtKB/Swiss-Prot
    P97783
    UniProtKB/TrEMBL
    Q543U0
    Related
    ENSMUSP00000143755.2, ENSMUST00000196025.5

  2. NM_001411091.1 → NP_001398020.1  protein AF1q

    Status: VALIDATED

    Source sequence(s)
    AC140190
    UniProtKB/Swiss-Prot
    P97783
    UniProtKB/TrEMBL
    Q543U0

  3. NM_001411092.1 → NP_001398021.1  protein AF1q

    Status: VALIDATED

    Source sequence(s)
    AC140190
    UniProtKB/Swiss-Prot
    P97783
    UniProtKB/TrEMBL
    Q543U0

  4. NM_019914.5 → NP_064298.1  protein AF1q

    See identical proteins and their annotated locations for NP_064298.1

    Status: VALIDATED

    Source sequence(s)
    AC140190
    Consensus CDS
    CCDS38544.1
    UniProtKB/Swiss-Prot
    P97783
    UniProtKB/TrEMBL
    Q543U0
    Related
    ENSMUSP00000066448.6, ENSMUST00000065482.6
    Conserved Domains (1) summary
    pfam15017
    Location:7 → 79
    WRNPLPNID; Putative WW-binding domain and destruction box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95125852..95139486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97783.1 GenPept UniProtKB/Swiss-Prot:P97783

Gene LinkOut

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