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PSG6 pregnancy specific beta-1-glycoprotein 6 [ Homo sapiens (human) ]

Gene ID: 5675, updated on 23-Nov-2023

Summary

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Official Symbol
PSG6provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 6provided by HGNC
Primary source
HGNC:HGNC:9523
See related
Ensembl:ENSG00000170848 MIM:176395; AllianceGenome:HGNC:9523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSG10; PSGGB; PSBG-6; PSBG-10; PSBG-12
Summary
This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Restricted expression toward placenta (RPKM 62.8) See more
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Genomic context

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Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42902086..42917894, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45721042..45736850, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43406238..43422046, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 10, pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 1 Neighboring gene pregnancy specific beta-1-glycoprotein 7 Neighboring gene CEA cell adhesion molecule pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Subtle differences in human pregnancy-specific glycoprotein gene promoters allow for differential expression. Chamberlin ME, et al. J Biol Chem, 1994 Jun 24. PMID 8006022
  2. Characterization of cDNAs of the human pregnancy-specific beta 1-glycoprotein family, a new subfamily of the immunoglobulin gene superfamily. Zheng QX, et al. Biochemistry, 1990 Mar 20. PMID 2346748
  3. cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. Zimmermann W, et al. Biochem Biophys Res Commun, 1989 Sep 29. PMID 2783133
  4. Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit. Barnett TR, et al. Biochemistry, 1990 Nov 6. PMID 2271648
  5. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. Leslie KK, et al. Proc Natl Acad Sci U S A, 1990 Aug. PMID 2377620, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: PSG2

Potential readthrough

Included gene: PSG11

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in female pregnancy NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pregnancy-specific beta-1-glycoprotein 6
Names
PS-beta-G-10
PS-beta-G-12
PS-beta-G-6
pregnancy-specific beta-1-glycoprotein 10
pregnancy-specific beta-1-glycoprotein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031850.4 → NP_001027020.1  pregnancy-specific beta-1-glycoprotein 6 isoform b precursor

    See identical proteins and their annotated locations for NP_001027020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI148792, BC020652, DA833634
    Consensus CDS
    CCDS33038.1
    UniProtKB/Swiss-Prot
    Q00889
    Related
    ENSP00000187910.3, ENST00000187910.7
    Conserved Domains (3) summary
    pfam13895
    Location:334 → 412
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36 → 139
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:241 → 328
    Ig; Immunoglobulin domain

  2. NM_002782.5 → NP_002773.1  pregnancy-specific beta-1-glycoprotein 6 isoform a precursor

    See identical proteins and their annotated locations for NP_002773.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    DA833634, M33666
    Consensus CDS
    CCDS12613.1
    UniProtKB/Swiss-Prot
    O75244, Q00889, Q15224, Q15235, Q549K1
    Related
    ENSP00000292125.2, ENST00000292125.6
    Conserved Domains (4) summary
    cd05774
    Location:36 → 139
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:338 → 398
    IG_like; Immunoglobulin like
    pfam13895
    Location:334 → 412
    Ig_2; Immunoglobulin domain
    cl11960
    Location:241 → 328
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42902086..42917894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45721042..45736850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00889.1 GenPept UniProtKB/Swiss-Prot:Q00889

Gene LinkOut

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