U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Psrc1 proline/serine-rich coiled-coil 1 [ Mus musculus (house mouse) ]

Gene ID: 56742, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Psrc1provided by MGI
Official Full Name
proline/serine-rich coiled-coil 1provided by MGI
Primary source
MGI:MGI:1913099
See related
Ensembl:ENSMUSG00000068744 AllianceGenome:MGI:1913099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dda3; 5430413I02Rik
Summary
Enables microtubule binding activity. Involved in several processes, including microtubule bundle formation; positive regulation of microtubule polymerization; and positive regulation of nitrogen compound metabolic process. Located in cytoplasm; midbody; and spindle. Is expressed in several structures, including brain ventricular layer; lung; rest of cerebellum marginal layer; submandibular gland primordium; and thymus primordium. Orthologous to human PSRC1 (proline and serine rich coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 24.5), limb E14.5 (RPKM 18.2) and 14 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 F3; 3 47.01 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108291120..108295547)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108383804..108388231)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19343 Neighboring gene STARR-seq mESC enhancer starr_08684 Neighboring gene sortilin 1 Neighboring gene myosin binding protein H-like Neighboring gene STARR-seq mESC enhancer starr_08685 Neighboring gene STARR-positive B cell enhancer ABC_E2094 Neighboring gene predicted gene 12522 Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene predicted gene, 52630 Neighboring gene STARR-seq mESC enhancer starr_08687 Neighboring gene seryl-tRNA synthetase 1 Neighboring gene predicted gene, 22942

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Proline/serine-rich coiled-coil protein 1 inhibits macrophage inflammation and delays atherosclerotic progression by binding to Annexin A2. Pan H, et al. Clin Transl Med, 2023 Mar. PMID 36932468, Free PMC Article
  2. Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE(-/-) mice. Luo T, et al. J Mol Cell Cardiol, 2022 Sep. PMID 35690006
  3. The impact of PSRC1 overexpression on gene and transcript expression profiling in the livers of ApoE(-/-) mice fed a high-fat diet. Wei M, et al. Mol Cell Biochem, 2020 Feb. PMID 31838625
  4. Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3. Luo T, et al. Gut Microbes, 2022 Jan-Dec. PMID 35613310, Free PMC Article
  5. PSRC1 overexpression attenuates atherosclerosis progression in apoE(-/-) mice by modulating cholesterol transportation and inflammation. Guo K, et al. J Mol Cell Cardiol, 2018 Mar. PMID 29378206

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proline/serine-rich coiled-coil protein 1 inhibits macrophage inflammation and delays atherosclerotic progression by binding to Annexin A2.
    Title: Proline/serine-rich coiled-coil protein 1 inhibits macrophage inflammation and delays atherosclerotic progression by binding to Annexin A2.
  2. Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE(-/-) mice.
    Title: Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE(-/-) mice.
  3. Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3.
    Title: Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3.
  4. findings reveal that PSRC1 may affect liver actin polymerization and cholesterol metabolism-related genes or pathways.
    Title: The impact of PSRC1 overexpression on gene and transcript expression profiling in the livers of ApoE(-/-) mice fed a high-fat diet.
  5. PSRC1 protects against the development of atherosclerosis and enhances the stability of plaques by modulating cholesterol transportation and inflammation in macrophages and the liver of apoE(-/-) mice.
    Title: PSRC1 overexpression attenuates atherosclerosis progression in apoE(-/-) mice by modulating cholesterol transportation and inflammation.
  6. DDA3 is a novel microtubule-associated protein that binds to EB3, and results implicate DDA3 and EB3 in the beta-catenin-mediated growth signaling.
    Title: p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway.
  7. molecular cloning, sequence analysis and gene expression
    Title: Cloning and characterization of human and mouse DDA3 genes.
  8. A p53 response element mediates transcriptional activation
    Title: Mouse DDA3 gene is a direct transcriptional target of p53 and p73.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC7063

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule bundle formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
proline/serine-rich coiled-coil protein 1
Names
differential display and activated by p53
p53-regulated DDA3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190161.1 → NP_001177090.1  proline/serine-rich coiled-coil protein 1

    See identical proteins and their annotated locations for NP_001177090.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK041835, BY231608
    Consensus CDS
    CCDS17758.1
    UniProtKB/Swiss-Prot
    Q8K4L8, Q9D0P7, Q9QXY5
    Related
    ENSMUSP00000099689.2, ENSMUST00000102629.8
    Conserved Domains (1) summary
    pfam15259
    Location:10 → 124
    GTSE1_N; G-2 and S-phase expressed 1

  2. NM_019976.3 → NP_064360.1  proline/serine-rich coiled-coil protein 1

    See identical proteins and their annotated locations for NP_064360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF156598, AK041835, BY080522
    Consensus CDS
    CCDS17758.1
    UniProtKB/Swiss-Prot
    Q8K4L8, Q9D0P7, Q9QXY5
    Related
    ENSMUSP00000088049.4, ENSMUST00000090561.10
    Conserved Domains (1) summary
    pfam15259
    Location:10 → 124
    GTSE1_N; G-2 and S-phase expressed 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108291120..108295547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0P7.2 GenPept UniProtKB/Swiss-Prot:Q9D0P7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous