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Rnf14 ring finger protein 14 [ Mus musculus (house mouse) ]

Gene ID: 56736, updated on 11-Apr-2024

Summary

Official Symbol
Rnf14provided by MGI
Official Full Name
ring finger protein 14provided by MGI
Primary source
MGI:MGI:1929668
See related
Ensembl:ENSMUSG00000060450 AllianceGenome:MGI:1929668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Triad2; D7Bwg0165e; D18Ertd188e; 2310075C09Rik; 2610005D23Rik
Summary
Predicted to enable androgen receptor binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Predicted to be involved in cellular protein metabolic process; positive regulation of nitrogen compound metabolic process; and regulation of androgen receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; genitourinary system; sensory organ; and trigeminal nerve. Orthologous to human RNF14 (ring finger protein 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 51.1), cortex adult (RPKM 38.6) and 28 other tissues See more
Orthologs
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Genomic context

Location:
18 B3; 18 20.2 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38410513..38450905)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (38277460..38317852)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700086O06 gene Neighboring gene 60S ribosomal protein L17-like Neighboring gene STARR-positive B cell enhancer ABC_E7580 Neighboring gene STARR-seq mESC enhancer starr_44353 Neighboring gene DAP3 binding cell death enhancer 1 Neighboring gene protocadherin 12 Neighboring gene STARR-seq mESC enhancer starr_44354 Neighboring gene predicted gene, 23205 Neighboring gene glucosamine-6-phosphate deaminase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10986 Neighboring gene predicted gene, 41702 Neighboring gene STARR-seq mESC enhancer starr_44355 Neighboring gene predicted gene, 52329

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF14
Names
TRIAD2 type I
androgen receptor-associated protein 54
protein Triad2
NP_001158093.1
NP_001158094.1
NP_001348193.1
NP_001348194.1
NP_001348195.1
NP_001348196.1
NP_001348197.1
NP_001348198.1
NP_064396.2
XP_006526189.1
XP_006526190.1
XP_006526191.1
XP_017173445.1
XP_017173446.1
XP_030106408.1
XP_030106410.1
XP_030106411.1
XP_030106412.1
XP_030106413.1
XP_030106414.1
XP_036017113.1
XP_036017115.1
XP_036017116.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164621.1NP_001158093.1  E3 ubiquitin-protein ligase RNF14 isoform a

    See identical proteins and their annotated locations for NP_001158093.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 4 through 9 encode the same isoform.
    Source sequence(s)
    BC049079, BC094250
    Consensus CDS
    CCDS29200.1
    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Related
    ENSMUSP00000126205.2, ENSMUST00000171461.3
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  2. NM_001164622.1NP_001158094.1  E3 ubiquitin-protein ligase RNF14 isoform b

    See identical proteins and their annotated locations for NP_001158094.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK038986, BC094250, CA315275
    Consensus CDS
    CCDS50261.1
    UniProtKB/TrEMBL
    G3XA54
    Related
    ENSMUSP00000133070.2, ENSMUST00000170811.8
    Conserved Domains (3) summary
    smart00647
    Location:164225
    IBR; In Between Ring fingers
    cd16628
    Location:93146
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:252308
    IBR; IBR domain, a half RING-finger domain
  3. NM_001361264.1NP_001348193.1  E3 ubiquitin-protein ligase RNF14 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
    Source sequence(s)
    AC152450
    Consensus CDS
    CCDS29200.1
    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  4. NM_001361265.1NP_001348194.1  E3 ubiquitin-protein ligase RNF14 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
    Source sequence(s)
    AC152450
    Consensus CDS
    CCDS29200.1
    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  5. NM_001361266.1NP_001348195.1  E3 ubiquitin-protein ligase RNF14 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
    Source sequence(s)
    AC152450
    Consensus CDS
    CCDS29200.1
    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  6. NM_001361267.1NP_001348196.1  E3 ubiquitin-protein ligase RNF14 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
    Source sequence(s)
    AC152450
    Consensus CDS
    CCDS29200.1
    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Related
    ENSMUSP00000157833.2, ENSMUST00000236116.2
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  7. NM_001361268.1NP_001348197.1  E3 ubiquitin-protein ligase RNF14 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
    Source sequence(s)
    AC152450
    Consensus CDS
    CCDS29200.1
    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  8. NM_001361269.1NP_001348198.1  E3 ubiquitin-protein ligase RNF14 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
    Source sequence(s)
    AC152450
    Consensus CDS
    CCDS29200.1
    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  9. NM_020012.2NP_064396.2  E3 ubiquitin-protein ligase RNF14 isoform a

    See identical proteins and their annotated locations for NP_064396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 through 9 encode the same isoform.
    Source sequence(s)
    BC054841, BC094250, CA315275
    Consensus CDS
    CCDS29200.1
    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Related
    ENSMUSP00000072212.6, ENSMUST00000072376.13
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    38410513..38450905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317957.1XP_017173446.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  2. XM_017317956.2XP_017173445.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  3. XM_036161220.1XP_036017113.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  4. XM_006526126.2XP_006526189.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    See identical proteins and their annotated locations for XP_006526189.1

    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  5. XM_036161222.1XP_036017115.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    G3XA54
    Conserved Domains (3) summary
    smart00647
    Location:164225
    IBR; In Between Ring fingers
    cd16628
    Location:93146
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:252308
    IBR; IBR domain, a half RING-finger domain
  6. XM_030250550.1XP_030106410.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    G3XA54
    Conserved Domains (3) summary
    smart00647
    Location:164225
    IBR; In Between Ring fingers
    cd16628
    Location:93146
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:252308
    IBR; IBR domain, a half RING-finger domain
  7. XM_030250551.1XP_030106411.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    G3XA54
    Conserved Domains (3) summary
    smart00647
    Location:164225
    IBR; In Between Ring fingers
    cd16628
    Location:93146
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:252308
    IBR; IBR domain, a half RING-finger domain
  8. XM_006526128.2XP_006526191.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    See identical proteins and their annotated locations for XP_006526191.1

    UniProtKB/TrEMBL
    G3XA54
    Conserved Domains (3) summary
    smart00647
    Location:164225
    IBR; In Between Ring fingers
    cd16628
    Location:93146
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:252308
    IBR; IBR domain, a half RING-finger domain
  9. XM_030250552.1XP_030106412.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    G3XA54
    Conserved Domains (3) summary
    smart00647
    Location:164225
    IBR; In Between Ring fingers
    cd16628
    Location:93146
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:252308
    IBR; IBR domain, a half RING-finger domain
  10. XM_030250553.1XP_030106413.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    G3XA54
    Conserved Domains (3) summary
    smart00647
    Location:164225
    IBR; In Between Ring fingers
    cd16628
    Location:93146
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:252308
    IBR; IBR domain, a half RING-finger domain
  11. XM_006526127.3XP_006526190.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    See identical proteins and their annotated locations for XP_006526190.1

    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain
  12. XM_030250554.1XP_030106414.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    G3XA54
    Conserved Domains (3) summary
    smart00647
    Location:164225
    IBR; In Between Ring fingers
    cd16628
    Location:93146
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:252308
    IBR; IBR domain, a half RING-finger domain
  13. XM_036161223.1XP_036017116.1  E3 ubiquitin-protein ligase RNF14 isoform X2

    UniProtKB/TrEMBL
    G3XA54
    Conserved Domains (3) summary
    smart00647
    Location:164225
    IBR; In Between Ring fingers
    cd16628
    Location:93146
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:252308
    IBR; IBR domain, a half RING-finger domain
  14. XM_030250548.1XP_030106408.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    Q7TPR0, Q9D0L2, Q9D6N2, Q9D6Z8, Q9JI89, Q9JI90
    Conserved Domains (4) summary
    smart00647
    Location:290351
    IBR; In Between Ring fingers
    cd16628
    Location:219272
    RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    pfam01485
    Location:378434
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:7133
    RWD; RWD domain