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PSG5 pregnancy specific beta-1-glycoprotein 5 [ Homo sapiens (human) ]

Gene ID: 5673, updated on 3-Apr-2024

Summary

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Official Symbol
PSG5provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 5provided by HGNC
Primary source
HGNC:HGNC:9522
See related
Ensembl:ENSG00000204941 MIM:176394; AllianceGenome:HGNC:9522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSG; FL-NCA-3
Summary
The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Expression
Restricted expression toward placenta (RPKM 117.8) See more
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Genomic context

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See PSG5 in Genome Data Viewer
Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43167743..43186536, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45988311..46007149, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43671895..43690688, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 2 Neighboring gene CEA cell adhesion molecule pseudogene 9 Neighboring gene PSG11, PSG2 and PSG5 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 9 pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 4 Neighboring gene uncharacterized LOC284344 Neighboring gene CEA cell adhesion molecule pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins. Camolotto SA, et al. PLoS One, 2013. PMID 23418492, Free PMC Article
  2. Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1. Blanchon L, et al. Biochem Biophys Res Commun, 2006 May 12. PMID 16563348
  3. Nucleotide sequence of a pregnancy-specific beta 1 glycoprotein gene family member. Identification of a functional promoter region and several putative regulatory sequences. Panzetta-Dutari GM, et al. Mol Biol Rep, 1992 Sep. PMID 1454058
  4. Placenta-derived, cellular messenger RNA expression in the maternal blood of preeclamptic women. Okazaki S, et al. Obstet Gynecol, 2007 Nov. PMID 17978129
  5. A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene. Oikawa S, et al. Biochem Biophys Res Commun, 1989 Sep 15. PMID 2789512

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. show that human PSG1 binds alphaIIbbeta3 and inhibits the platelet - fibrinogen interaction. Unexpectedly, however, the KGD is not critical as multiple PSG1 domains independently bind and inhibit alphaIIbbeta3 function
    Title: Pregnancy-specific glycoproteins bind integrin αIIbβ3 and inhibit the platelet-fibrinogen interaction.
  2. esults are consistent with a regulatory role of lysine acetylation on PSG expression through a relaxed chromatin state and an increase in the transcriptional activity of Sp1 and KLF6 following an augmented Sp1 acetylation and KLF6 nuclear localization.
    Title: PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins.
  3. the mRNA expression of PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN is up-regulated in cells circulating within blood from women with preeclampsia, and is positively correlated with cliical severity
    Title: Placenta-derived, cellular messenger RNA expression in the maternal blood of preeclamptic women.
  4. Strong synergic activity of KLF4 and Sp1 on the PSG-5 promoter.
    Title: Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in female pregnancy TAS
Traceable Author Statement
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pregnancy-specific beta-1-glycoprotein 5
Names
PS-beta-G-5
PSBG-5
Pregnancy-specific beta-1-glycoprotein-5
fetal liver non-specific cross-reactive antigen 3
pregnancy-specific beta 1 glycoprotein
pregnancy-specific glycoprotein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130014.2 → NP_001123486.1  pregnancy-specific beta-1-glycoprotein 5 precursor

    See identical proteins and their annotated locations for NP_001123486.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 3' exon, as compared to variant 1.
    Source sequence(s)
    AA151017, BC012607, BG622527, DA835167, M25384, M73713
    Consensus CDS
    CCDS12617.1
    UniProtKB/Swiss-Prot
    Q15238, Q15239, Q96QJ1, Q9UQ75
    UniProtKB/TrEMBL
    E7EQY3
    Related
    ENSP00000386008.1, ENST00000407356.5
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246 → 320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242 → 320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

  2. NM_002781.4 → NP_002772.3  pregnancy-specific beta-1-glycoprotein 5 precursor

    See identical proteins and their annotated locations for NP_002772.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC012607, BG621332, BG622527, DA835167, M25384
    Consensus CDS
    CCDS12617.1
    UniProtKB/Swiss-Prot
    Q15238, Q15239, Q96QJ1, Q9UQ75
    UniProtKB/TrEMBL
    E7EQY3
    Related
    ENSP00000344413.6, ENST00000342951.11
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246 → 320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242 → 320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43167743..43186536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027003.2 → XP_016882492.1  pregnancy-specific beta-1-glycoprotein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q15238, Q15239, Q96QJ1, Q9UQ75
    UniProtKB/TrEMBL
    E7EQY3
    Conserved Domains (4) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246 → 320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242 → 320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:148 → 236
    Ig; Immunoglobulin domain

  2. XM_011527132.4 → XP_011525434.1  pregnancy-specific beta-1-glycoprotein 5 isoform X2

    Conserved Domains (1) summary
    cd05774
    Location:36 → 138
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45988311..46007149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321490.1 → XP_054177465.1  pregnancy-specific beta-1-glycoprotein 5 isoform X1

  2. XM_054321491.1 → XP_054177466.1  pregnancy-specific beta-1-glycoprotein 5 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15238.3 GenPept UniProtKB/Swiss-Prot:Q15238

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