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Plag1 pleiomorphic adenoma gene 1 [ Mus musculus (house mouse) ]

Gene ID: 56711, updated on 21-Apr-2024

Summary

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Official Symbol
Plag1provided by MGI
Official Full Name
pleiomorphic adenoma gene 1provided by MGI
Primary source
MGI:MGI:1891916
See related
Ensembl:ENSMUSG00000003282 AllianceGenome:MGI:1891916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; positive regulation of gene expression; and positive regulation of glial cell proliferation. Acts upstream of or within gland morphogenesis and prostate gland growth. Predicted to be located in centrosome; cytosol; and nuclear speck. Is expressed in several structures, including brain; embryo ectoderm; genitourinary system; limb bud; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome and pleomorphic adenoma. Orthologous to human PLAG1 (PLAG1 zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 2.3), CNS E11.5 (RPKM 1.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A1; 4 2.18 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (3895209..3938429, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (3898769..3938430, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32823 Neighboring gene STARR-seq mESC enhancer starr_09428 Neighboring gene predicted gene, 24125 Neighboring gene STARR-seq mESC enhancer starr_09429 Neighboring gene Moloney sarcoma oncogene Neighboring gene STARR-positive B cell enhancer ABC_E830 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 7 Neighboring gene ubiquitin protein ligase E3 component n-recognin 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice. Tran SC, et al. Neuroscience, 2021 Feb 10. PMID 33346119
  2. Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes. Wong J, et al. Dev Dyn, 2020 Dec. PMID 32959928
  3. Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis. Wong J, et al. Asian J Androl, 2020 Jul-Aug. PMID 31464202, Free PMC Article
  4. Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development. Madissoon E, et al. Sci Rep, 2019 Jun 10. PMID 31182756, Free PMC Article
  5. Dysregulated long non‑coding RNAs in pleomorphic adenoma tissues of pleomorphic adenoma gene 1 transgenic mice. Xu W, et al. Mol Med Rep, 2019 Jun. PMID 31059011, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes.
    Title: Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes.
  2. Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis.
    Title: Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis.
  3. Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice.
    Title: Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice.
  4. Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development.
    Title: Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development.
  5. lncRNAs and mRNAs were differentially expressed in pleomorphic adenoma tissues obtained from PLAG1 transgenic mice as compared with those from control mice. These differentially expressed lncRNAs may act as novel biomarkers and therapeutic targets for pleomorphic adenoma.
    Title: Dysregulated long non‑coding RNAs in pleomorphic adenoma tissues of pleomorphic adenoma gene 1 transgenic mice.
  6. PLAG1 deficiency does not have a major impact on the reproductive control by the hypothalamo-pituitary system.
    Title: PLAG1 expression and target genes in the hypothalamo-pituitary system in male mice.
  7. Loss of PLAG1 resulted in significantly lowered daily sperm production, in reduced sperm motility, and in several animals, in sloughing of the germinal epithelium. The results demonstrate that the subfertility seen in male PLAG1-deficient mice is, at least in part, the result of significantly reduced sperm output and sperm motility.
    Title: PLAG1 deficiency impairs spermatogenesis and sperm motility in mice.
  8. Forced expression of PLAG1 under the control of the Pdx1 or Ngn3 promoter in murine pancreas induces different degrees of endocrine hormone imbalances.
    Title: Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism.
  9. Data indicate a plausible Plag1-Egr1-CD44 regulatory pathway in the T-ICs of pleomorphic adenomas.
    Title: Tumor-initiating cells are enriched in CD44(hi) population in murine salivary gland tumor.
  10. results establish the oncogenic potential of PLAG1 in mammary glands of mice and point towards contributing roles of Igf and Wnt signaling
    Title: Adenomyoepitheliomatous lesions of the mammary glands in transgenic mice with targeted PLAG1 overexpression.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within prostate gland growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein PLAG1
Names
C2H2 zinc finger protein PLAG1
pleiomorphic adenoma gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019969.3 → NP_064353.2  zinc finger protein PLAG1

    See identical proteins and their annotated locations for NP_064353.2

    Status: VALIDATED

    Source sequence(s)
    AL807387, BC139283, CJ178210
    Consensus CDS
    CCDS17941.1
    UniProtKB/Swiss-Prot
    B1AXC4, Q3UXC0, Q9QYE0
    Related
    ENSMUSP00000003369.4, ENSMUST00000003369.10
    Conserved Domains (3) summary
    COG5189
    Location:58 → 139
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:36 → 56
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:79 → 103
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    3895209..3938429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538116.5 → XP_006538179.1  zinc finger protein PLAG1 isoform X1

    See identical proteins and their annotated locations for XP_006538179.1

    UniProtKB/Swiss-Prot
    B1AXC4, Q3UXC0, Q9QYE0
    Conserved Domains (3) summary
    COG5189
    Location:58 → 139
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:36 → 56
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:79 → 103
    zf-H2C2_2; Zinc-finger double domain

  2. XM_036164269.1 → XP_036020162.1  zinc finger protein PLAG1 isoform X1

    UniProtKB/Swiss-Prot
    B1AXC4, Q3UXC0, Q9QYE0
    Conserved Domains (3) summary
    COG5189
    Location:58 → 139
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:36 → 56
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:79 → 103
    zf-H2C2_2; Zinc-finger double domain

  3. XM_006538122.5 → XP_006538185.1  zinc finger protein PLAG1 isoform X3

    See identical proteins and their annotated locations for XP_006538185.1

    Conserved Domains (3) summary
    COG5236
    Location:39 → 154
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:70 → 90
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:10 → 58
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  4. XM_036164273.1 → XP_036020166.1  zinc finger protein PLAG1 isoform X3

    Conserved Domains (3) summary
    COG5236
    Location:39 → 154
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:70 → 90
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:10 → 58
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  5. XM_036164272.1 → XP_036020165.1  zinc finger protein PLAG1 isoform X3

    Conserved Domains (3) summary
    COG5236
    Location:39 → 154
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:70 → 90
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:10 → 58
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  6. XM_036164271.1 → XP_036020164.1  zinc finger protein PLAG1 isoform X2

    Conserved Domains (3) summary
    COG5236
    Location:41 → 156
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:72 → 92
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:12 → 60
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  7. XM_017320331.3 → XP_017175820.1  zinc finger protein PLAG1 isoform X1

    UniProtKB/Swiss-Prot
    B1AXC4, Q3UXC0, Q9QYE0
    Conserved Domains (3) summary
    COG5189
    Location:58 → 139
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:36 → 56
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:79 → 103
    zf-H2C2_2; Zinc-finger double domain

  8. XM_036164270.1 → XP_036020163.1  zinc finger protein PLAG1 isoform X1

    UniProtKB/Swiss-Prot
    B1AXC4, Q3UXC0, Q9QYE0
    Conserved Domains (3) summary
    COG5189
    Location:58 → 139
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:36 → 56
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:79 → 103
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYE0.2 GenPept UniProtKB/Swiss-Prot:Q9QYE0

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