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Zfp111 zinc finger protein 111 [ Mus musculus (house mouse) ]

Gene ID: 56707, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp111provided by MGI
Official Full Name
zinc finger protein 111provided by MGI
Primary source
MGI:MGI:1929114
See related
Ensembl:ENSMUSG00000087598 AllianceGenome:MGI:1929114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in early conceptus; genitourinary system; and gut. Orthologous to human ZNF235 (zinc finger protein 235). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
7 A3; 7 10.27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (23890760..23907574, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24193215..24208149, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2817 Neighboring gene zinc finger protein 235 Neighboring gene STARR-seq mESC enhancer starr_18251 Neighboring gene zinc finger protein 114 Neighboring gene zinc finger protein 109 Neighboring gene zinc finger protein 108

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role for a Zinc Finger Protein (Zfp111) in Transformation of 208F Rat Fibroblasts by Jaagsiekte Sheep Retrovirus Envelope Protein. Hsu T, et al. J Virol, 2015 Oct. PMID 26246563, Free PMC Article
  2. Identification and characterization of reproductive KRAB-ZF genes in mice. Jin S, et al. Gene, 2015 Jul 1. PMID 25827285
  3. Multidimensional genome scans identify the combinations of genetic loci linked to diabetes-related phenotypes in mice. Togawa K, et al. Hum Mol Genet, 2006 Jan 1. PMID 16321990
  4. Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice. Michaud EJ, et al. BMC Genomics, 2005 Nov 21. PMID 16300676, Free PMC Article
  5. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel cellular protein, Zfp111, binds to the JSRV Env protein, and this binding plays a role in retroviral transformation.
    Title: Role for a Zinc Finger Protein (Zfp111) in Transformation of 208F Rat Fibroblasts by Jaagsiekte Sheep Retrovirus Envelope Protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4) 
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 111

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310670.1 → NP_001297599.1  zinc finger protein 111 isoform 2

    See identical proteins and their annotated locations for NP_001297599.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two 5' exons and its 5' terminal exon begins before a splice site that is used in variant 1. This results in a novel 5' coding region and 5' UTR, compared to variant 1. It encodes isoform 2 which has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC138791, BB618616, BP758385, BU056699
    Consensus CDS
    CCDS80674.1
    UniProtKB/TrEMBL
    Q9R164
    Related
    ENSMUSP00000129484.2, ENSMUST00000056683.3
    Conserved Domains (5) summary
    smart00349
    Location:9 → 58
    KRAB; krueppel associated box
    COG5048
    Location:210 → 619
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:575 → 595
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:9 → 48
    KRAB; KRAB box
    pfam13465
    Location:615 → 640
    zf-H2C2_2; Zinc-finger double domain

  2. NM_019940.2 → NP_064324.2  zinc finger protein 111 isoform 1

    See identical proteins and their annotated locations for NP_064324.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AC138791, AF167318, AK045800, BB618616
    Consensus CDS
    CCDS20944.2
    UniProtKB/TrEMBL
    Q99K53
    Related
    ENSMUSP00000083169.6, ENSMUST00000086006.12
    Conserved Domains (5) summary
    smart00349
    Location:8 → 57
    KRAB; krueppel associated box
    COG5048
    Location:209 → 618
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:574 → 594
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:614 → 639
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    23890760..23907574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242815.2 → XP_030098675.1  zinc finger protein 111 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:377 → 672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:605 → 625
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:39 → 79
    KRAB; KRAB box
    pfam13465
    Location:674 → 696
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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