U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ccnl1 cyclin L1 [ Mus musculus (house mouse) ]

Gene ID: 56706, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ccnl1provided by MGI
Official Full Name
cyclin L1provided by MGI
Primary source
MGI:MGI:1922664
See related
Ensembl:ENSMUSG00000027829 AllianceGenome:MGI:1922664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccnl; ania-6a; 2610030E23Rik
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in head. Orthologous to human CCNL1 (cyclin L1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 21.2), thymus adult (RPKM 20.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 E1; 3 30.25 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (65853333..65869451, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (65945908..65962029, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54198 Neighboring gene STARR-positive B cell enhancer ABC_E9008 Neighboring gene predicted gene, 35039 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:65761281-65761390 Neighboring gene STARR-seq mESC enhancer starr_07873 Neighboring gene 40S ribosomal protein S27-like pseudogene Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel cyclin provides a link between dopamine and RNA processing. Nairn AC, et al. Neuron, 2001 Oct 25. PMID 11683987
  2. Regulation of ania-6 splice variants by distinct signaling pathways in striatal neurons. Sgambato V, et al. J Neurochem, 2003 Jul. PMID 12807435
  3. CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing. Chen HH, et al. Biochem Biophys Res Commun, 2007 Mar 16. PMID 17261272
  4. CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis. Rakkaa T, et al. Chromosome Res, 2014 Sep. PMID 24436071
  5. CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway. Yun X, et al. Mol Cell Biochem, 2007 Oct. PMID 17516030

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of centrosome cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cyclin-L1
Names
cyclin ania-6a
cyclin-L

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355432.1 → NP_001342361.1  cyclin-L1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165307, BC094383
    Conserved Domains (1) summary
    cl28538
    Location:41 → 139
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

  2. NM_001355433.1 → NP_001342362.1  cyclin-L1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC165307, BC094383
    Conserved Domains (1) summary
    cl28538
    Location:21 → 119
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

  3. NM_019937.4 → NP_064321.2  cyclin-L1 isoform 1

    See identical proteins and their annotated locations for NP_064321.2

    Status: VALIDATED

    Source sequence(s)
    AC165307, BC094383, CJ150556
    Consensus CDS
    CCDS17390.1
    UniProtKB/Swiss-Prot
    Q52KE7, Q8BQ75, Q8R5H9, Q922K0, Q9CSZ3, Q9WV44
    Related
    ENSMUSP00000029416.8, ENSMUST00000029416.14
    Conserved Domains (2) summary
    smart00385
    Location:211 → 280
    CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
    cd00043
    Location:88 → 160
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    65853333..65869451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252700.2 → XP_030108560.1  cyclin-L1 isoform X1

    Conserved Domains (1) summary
    COG5333
    Location:39 → 137
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

  2. XM_036163178.1 → XP_036019071.1  cyclin-L1 isoform X2

    Related
    ENSMUST00000122919.8
    Conserved Domains (1) summary
    cl40454
    Location:5 → 100
    CYCLIN_SF; Cyclin box fold superfamily

  3. XM_036163179.1 → XP_036019072.1  cyclin-L1 isoform X2

    Conserved Domains (1) summary
    cl40454
    Location:5 → 100
    CYCLIN_SF; Cyclin box fold superfamily

  4. XM_011240174.4 → XP_011238476.1  cyclin-L1 isoform X3

    Conserved Domains (1) summary
    COG5333
    Location:80 → 233
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

RNA

  1. XR_867222.4 RNA Sequence

  2. XR_004941367.1 RNA Sequence

  3. XR_004941366.1 RNA Sequence

  4. XR_004941368.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025442.1: Suppressed sequence

    Description
    NM_001025442.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.

  2. NM_001025443.1: Suppressed sequence

    Description
    NM_001025443.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q52KE7.1 GenPept UniProtKB/Swiss-Prot:Q52KE7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous