PSG2 pregnancy specific beta-1-glycoprotein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PSG2provided by HGNC
Official Full Name: pregnancy specific beta-1-glycoprotein 2provided by HGNC
Primary source: HGNC:HGNC:9519
See related: Ensembl:ENSG00000242221 MIM:176391; AllianceGenome:HGNC:9519
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CEA; PSG1; PSBG2
Summary: The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Expression: Restricted expression toward placenta (RPKM 263.6) See more
Orthologs: all
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Genomic context

Location:: 19q13.31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (43064209..43082701, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (45884784..45903261, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (43568361..43586853, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrating the dual-signal amplification strategy, a novel 3D origami electrochemical immunodevice for simultaneous detecting carcinoembryonic antigen (CEA) and cancer antigen 125 (CA125)
Title: 3D origami electrochemical immunodevice for sensitive point-of-care testing based on dual-signal amplification strategy.
the authors evaluated the prognostic significance of the CEA and CA-19.9 serum tumor markers in advanced (unresectable) pancreatic cancer
Title: CEA and CA-19.9 serum tumor markers as prognostic factors in patients with locally advanced (unresectable) or metastatic pancreatic adenocarcinoma: a retrospective analysis.
This genetic cancer vaccineis highly immunogenic and can break tolerance to CEA tumor antigen in CEA transgenic mice.
Title: Efficient induction of T-cell responses to carcinoembryonic antigen by a heterologous prime-boost regimen using DNA and adenovirus vectors carrying a codon usage optimized cDNA.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:374803 (e-PCR)
- UniSTS:156965

WI-17469 (e-PCR)
- UniSTS:51573

RH69096 (e-PCR)
- UniSTS:64143

G61993 (e-PCR)
- UniSTS:139212

STS-N26627 (e-PCR)
- UniSTS:39151

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in female pregnancy	NAS Non-traceable Author Statement more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pregnancy-specific beta-1-glycoprotein 2

Names: PS-beta-E; PS-beta-G-2; PSBG-2; carcinoembryonic antigen SG8; pregnancy-specific beta-1 glycoprotein E; pregnancy-specific beta-1-glycoprotein 7; pregnancy-specific glycoprotein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031246.4 → NP_112536.2 pregnancy-specific beta-1-glycoprotein 2 precursor

See identical proteins and their annotated locations for NP_112536.2

Status: VALIDATED

Source sequence(s)

AC024077

Consensus CDS

CCDS12616.1

UniProtKB/Swiss-Prot

P11465, Q8TCD9, Q9UEA4, Q9UQ78

UniProtKB/TrEMBL

A0A0F7CSH9

Related

ENSP00000385706.1, ENST00000406487.6

Conserved Domains (4) summary

cd05774
Location:36 → 138

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:246 → 318

IG_like; Immunoglobulin like

pfam13895
Location:242 → 320

Ig_2; Immunoglobulin domain

cl11960
Location:148 → 236

Ig; Immunoglobulin domain