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Phax phosphorylated adaptor for RNA export [ Mus musculus (house mouse) ]

Gene ID: 56698, updated on 5-Mar-2024

Summary

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Official Symbol
Phaxprovided by MGI
Official Full Name
phosphorylated adaptor for RNA exportprovided by MGI
Primary source
MGI:MGI:1891839
See related
Ensembl:ENSMUSG00000008301 AllianceGenome:MGI:1891839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p55; Rnuxa; D18Ertd65e; 2810055C14Rik; 4933427L19Rik
Summary
Predicted to enable mRNA cap binding complex binding activity and toxic substance binding activity. Acts upstream of or within snRNA export from nucleus. Located in cytoplasm and nucleus. Orthologous to human PHAX (phosphorylated adaptor for RNA export). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 28.4), CNS E18 (RPKM 25.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Phax in Genome Data Viewer
Location:
18 D3; 18 30.63 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56695641..56720784)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56562569..56587712)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene glutamate-ammonia ligase (glutamine synthetase) pseudogene Neighboring gene aldehyde dehydrogenase family 7, member A1 Neighboring gene STARR-seq mESC enhancer starr_44664 Neighboring gene microRNA 1258 Neighboring gene sperm microtubule inner protein 10 Neighboring gene predicted gene, 50288 Neighboring gene STARR-seq mESC enhancer starr_44668 Neighboring gene STARR-positive B cell enhancer ABC_E5662 Neighboring gene predicted gene, 41738

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export. Segref A, et al. RNA, 2001 Mar. PMID 11333016, Free PMC Article
  2. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Ohno M, et al. Cell, 2000 Apr 14. PMID 10786834
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA cap binding complex binding ISO
Inferred from Sequence Orthology
more info
  
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within snRNA export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphorylated adapter RNA export protein
Names
RNA U small nuclear RNA export adapter protein
RNA U, small nuclear RNA export adaptor
phosphorylation regulated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162989.1 → NP_001156461.1  phosphorylated adapter RNA export protein isoform 2

    See identical proteins and their annotated locations for NP_001156461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK012949, AK016958, BC049590
    Consensus CDS
    CCDS50292.1
    UniProtKB/TrEMBL
    G5E8V8
    Related
    ENSMUSP00000122948.2, ENSMUST00000130163.8
    Conserved Domains (1) summary
    pfam10258
    Location:199 → 282
    RNA_GG_bind; PHAX RNA-binding domain

  2. NM_019996.4 → NP_064380.3  phosphorylated adapter RNA export protein isoform 1

    See identical proteins and their annotated locations for NP_064380.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK012949, BC049590, CJ157832
    Consensus CDS
    CCDS29259.1
    UniProtKB/Swiss-Prot
    Q8BSR8, Q9JJT9
    UniProtKB/TrEMBL
    A0PJ63
    Related
    ENSMUSP00000008445.6, ENSMUST00000008445.7
    Conserved Domains (1) summary
    pfam10258
    Location:221 → 304
    RNA_GG_bind; PHAX RNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    56695641..56720784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJT9.1 GenPept UniProtKB/Swiss-Prot:Q9JJT9

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