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Akap10 A kinase anchor protein 10 [ Mus musculus (house mouse) ]

Gene ID: 56697, updated on 21-Apr-2024

Summary

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Official Symbol
Akap10provided by MGI
Official Full Name
A kinase anchor protein 10provided by MGI
Primary source
MGI:MGI:1890218
See related
Ensembl:ENSMUSG00000047804 AllianceGenome:MGI:1890218
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRKA10; D-AKAP2; D-AKAP-2; 1500031L16Rik; B130049N18Rik
Summary
This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. It has been reported that this protein is important for maintaining heart rate and myocardial contractility through its targeting of protein kinase A. In mouse, defects of this gene lead to cardiac arrhythmias and premature death. In humans, polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in cerebellum adult (RPKM 4.1), frontal lobe adult (RPKM 3.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B2; 11 37.96 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61756029..61821134, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61865203..61930308, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene unc-51 like kinase 2 Neighboring gene STARR-seq mESC enhancer starr_29688 Neighboring gene STARR-seq mESC enhancer starr_29689 Neighboring gene STARR-positive B cell enhancer ABC_E8413 Neighboring gene predicted gene, 23721 Neighboring gene predicted gene 12273

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. Burns LL, et al. Biochemistry, 2003 May 20. PMID 12741833
  2. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Tingley WG, et al. Proc Natl Acad Sci U S A, 2007 May 15. PMID 17485678, Free PMC Article
  3. Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Burns-Hamuro LL, et al. Protein Sci, 2005 Dec. PMID 16260760, Free PMC Article
  4. PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Gisler SM, et al. Kidney Int, 2003 Nov. PMID 14531807
  5. Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). Hamuro Y, et al. J Mol Biol, 2002 Aug 23. PMID 12206784

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein
    Title: Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS).
  2. D-AKAP2 may play an important role in the parathyroid hormone (PTH)-mediated regulation of NaPi-IIa by compartmentalization of PKA.
    Title: PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells.
  3. These studies suggest a role for AKAP10 in heart rhythm control.
    Title: Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase A binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 10, mitochondrial
Names
A kinase (PRKA) anchor protein 10
dual specificity A kinase-anchoring protein 2
protein kinase A-anchoring protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019921.3 → NP_064305.2  A-kinase anchor protein 10, mitochondrial precursor

    See identical proteins and their annotated locations for NP_064305.2

    Status: REVIEWED

    Source sequence(s)
    AK049399, AL646042
    Consensus CDS
    CCDS24821.1
    UniProtKB/Swiss-Prot
    O88845, Q5SUB5, Q5SUB7, Q7TPE7, Q8BQL6
    Related
    ENSMUSP00000099710.4, ENSMUST00000102650.10
    Conserved Domains (3) summary
    cd08721
    Location:383 → 503
    RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
    cd08735
    Location:122 → 367
    RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
    cd12804
    Location:618 → 662
    AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61756029..61821134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533814.5 → XP_006533877.1  A-kinase anchor protein 10, mitochondrial isoform X1

    Conserved Domains (3) summary
    cd08721
    Location:354 → 474
    RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
    cd08735
    Location:93 → 338
    RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
    cd12804
    Location:589 → 633
    AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

RNA

  1. XR_879723.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88845.3 GenPept UniProtKB/Swiss-Prot:O88845

Gene LinkOut

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