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Mlycd malonyl-CoA decarboxylase [ Mus musculus (house mouse) ]

Gene ID: 56690, updated on 5-Mar-2024

Summary

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Official Symbol
Mlycdprovided by MGI
Official Full Name
malonyl-CoA decarboxylaseprovided by MGI
Primary source
MGI:MGI:1928485
See related
Ensembl:ENSMUSG00000074064 AllianceGenome:MGI:1928485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mcd
Summary
Enables malonyl-CoA decarboxylase activity. Involved in malonyl-CoA catabolic process and positive regulation of fatty acid oxidation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; nervous system; nose; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in cardiomyopathy. Orthologous to human MLYCD (malonyl-CoA decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 29.4), liver adult (RPKM 25.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mlycd in Genome Data Viewer
Location:
8 E1; 8 67.64 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120121591..120148577)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119394852..119421838)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10525 Neighboring gene heat shock factor binding protein 1 Neighboring gene predicted gene 45723 Neighboring gene STARR-positive B cell enhancer ABC_E3809 Neighboring gene predicted gene, 32006 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:121947490-121947599 Neighboring gene STARR-positive B cell enhancer ABC_E2879 Neighboring gene STARR-positive B cell enhancer ABC_E10526 Neighboring gene oxidative stress induced growth inhibitor 1 Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene predicted gene, 53462

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice. Ussher JR, et al. Diabetes, 2016 Jul. PMID 27207536
  2. Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity. Aksentijević D, et al. J Mol Cell Cardiol, 2014 Oct. PMID 25066696, Free PMC Article
  3. Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation. Masoud WG, et al. Cardiovasc Res, 2014 Jan 1. PMID 24048945
  4. Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. Ussher JR, et al. Diabetes, 2009 Aug. PMID 19478144, Free PMC Article
  5. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Koves TR, et al. Cell Metab, 2008 Jan. PMID 18177724

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased fat oxidation in MCD(-/-) mice resulted in the accumulation of lipid intermediates in peripheral tissues, but this was not associated with a worsening of age-associated insulin resistance and, conversely, improved longevity.
    Title: Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice.
  2. MCD(-/-) mice consistently exhibited cardiac dysfunction and severe metabolic perturbations while on a high-fat, low carbohydrate diet of maternal milk and these gradually resolved post-weaning.
    Title: Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.
  3. Data indicate that a full-dosage of p53 and an intact ribosomal protein-murine double minute 2 protein (Mdm2)-p53 pathway are required for the induction of malonyl coA decarboxylase (MCD), a critical regulator of fatty acid oxidation.
    Title: Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation.
  4. SIRT4 deacetylates and represses malonyl CoA decarboxylase, regulating malonyl coA levels.
    Title: SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
  5. This study of fatty acid oxidation and malonyl-CoA decarboxylase identifies a critical role for metabolism in both the normal pulmonary circulation (hypoxic pulmonary vasoconstriction) and pulmonary hypertension
    Title: Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension.
  6. Mcd deficiency is not detrimental to the heart in obesity in mice.
    Title: Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
  7. In vivo and ex vivo cardiac function is similar in wild-type and mcd-deficient mice; however, deletion of MCD markedly increases glucose oxidation and improves functional recovery of the heart after ischemia.
    Title: Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables malonyl-CoA decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables malonyl-CoA decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables malonyl-CoA decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in malonyl-CoA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in malonyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in malonyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fatty acid oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
malonyl-CoA decarboxylase, mitochondrial
NP_001351257.1
NP_064350.2
XP_006531281.1
XP_006531285.1
XP_006531288.1
XP_006531289.1
XP_011246759.1
XP_017168411.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364328.1 → NP_001351257.1  malonyl-CoA decarboxylase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166781
    Conserved Domains (1) summary
    pfam05292
    Location:94 → 365
    MCD; Malonyl-CoA decarboxylase (MCD)

  2. NM_019966.3 → NP_064350.2  malonyl-CoA decarboxylase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_064350.2

    Status: VALIDATED

    Source sequence(s)
    AC166781
    Consensus CDS
    CCDS22703.1
    UniProtKB/Swiss-Prot
    Q7TNL6, Q99J39
    Related
    ENSMUSP00000095970.5, ENSMUST00000098367.5
    Conserved Domains (1) summary
    pfam05292
    Location:94 → 455
    MCD; Malonyl-CoA decarboxylase (MCD)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    120121591..120148577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248457.4 → XP_011246759.1  malonyl-CoA decarboxylase, mitochondrial isoform X2

    Conserved Domains (2) summary
    pfam05292
    Location:192 → 315
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:94 → 189
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain

  2. XM_017312922.3 → XP_017168411.1  malonyl-CoA decarboxylase, mitochondrial isoform X4

    Conserved Domains (2) summary
    pfam05292
    Location:192 → 315
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:94 → 189
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain

  3. XM_006531222.5 → XP_006531285.1  malonyl-CoA decarboxylase, mitochondrial isoform X3

    Conserved Domains (2) summary
    pfam05292
    Location:192 → 315
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:94 → 189
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain

  4. XM_006531225.5 → XP_006531288.1  malonyl-CoA decarboxylase, mitochondrial isoform X5

    Conserved Domains (2) summary
    pfam05292
    Location:192 → 315
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:94 → 189
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain

  5. XM_006531226.5 → XP_006531289.1  malonyl-CoA decarboxylase, mitochondrial isoform X6

    Conserved Domains (2) summary
    pfam05292
    Location:192 → 316
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:94 → 189
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain

  6. XM_006531218.5 → XP_006531281.1  malonyl-CoA decarboxylase, mitochondrial isoform X1

    Conserved Domains (2) summary
    pfam05292
    Location:174 → 437
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:105 → 171
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99J39.1 GenPept UniProtKB/Swiss-Prot:Q99J39

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