Klk4 kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klk4provided by MGI
Official Full Name: kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)provided by MGI
Primary source: MGI:MGI:1861379
See related: Ensembl:ENSMUSG00000006948 AllianceGenome:MGI:1861379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PSTS; ESMP1; KLK-L1; Prss17
Summary: Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Acts upstream of or within amelogenesis; extracellular matrix disassembly; and protein catabolic process. Predicted to be located in extracellular region. Predicted to be active in secretory granule. Is expressed in epididymis; ileum; prostate gland; skin; and upper jaw incisor. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A1 and prostate cancer. Orthologous to human KLK4 (kallikrein related peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.35 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43530584..43535228)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43881160..43885804)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process.
Title: Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process.
NaF reduces KLK4 expression by decreasing Foxo1/Runx2 expression in LS8 cells.
Title: NaF reduces KLK4 expression by decreasing Foxo1/Runx2 expression in LS8 cells.
normal enamel maturation is regulated by TGF-ss signaling through the expression of KLK4
Title: TGF-ß regulates enamel mineralization and maturation through KLK4 expression.
The breakage of enamel near the dentino-enamel junction in Klk4-null mice is not due to a failure of odontoblasts to express Klk4, but it relates to a progressive hypomineralization of enamel with depth.
Title: Why does enamel in Klk4-null mice break above the dentino-enamel junction?
Effect of kallikrein 4 loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20.
Title: Effect of kallikrein 4 loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20.
Klk4 is essential for the removal of enamel proteins and the proper maturation of enamel crystals in mice
Title: Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice.
Dipeptidyl peptidase I activates pro-KLK4 to cleave a fluorogenic peptide containing a KLK4 cleavage site in mice incisor enamel organs during amelogenesis. site.
Title: DPPI may activate KLK4 during enamel formation.
Mice lacking expression of the AmelX, Enam and Mmp20 genes have been generated.
Title: Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4.
expression of KLK4 correlates with the stage-associated changes in the digestion of enamel proteins
Title: Enamelysin and kallikrein-4 mRNA expression in developing mouse molars.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489220

AF019979 (e-PCR)
- UniSTS:163415

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amelogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within amelogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amelogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix disassembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-4

Names: enamel matrix serine proteinase 1; kallikrein-like protein 1; protease, serine 17 (enamel matrix, prostate)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019928.2 → NP_064312.1 kallikrein-4 precursor

See identical proteins and their annotated locations for NP_064312.1

Status: VALIDATED

Source sequence(s)

AK087426, BC100717

Consensus CDS

CCDS21186.1

UniProtKB/Swiss-Prot

Q9JIS2, Q9Z0M1

UniProtKB/TrEMBL

A0A1R3UDT0

Related

ENSMUSP00000007161.6, ENSMUST00000007161.8

Conserved Domains (1) summary

cd00190
Location:32 → 251

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...