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Trim17 tripartite motif-containing 17 [ Mus musculus (house mouse) ]

Gene ID: 56631, updated on 11-Apr-2024

Summary

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Official Symbol
Trim17provided by MGI
Official Full Name
tripartite motif-containing 17provided by MGI
Primary source
MGI:MGI:1861440
See related
Ensembl:ENSMUSG00000036964 AllianceGenome:MGI:1861440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
terf; Rnf16
Summary
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including autophagy; innate immune response; and protein autoubiquitination. Predicted to be active in cytoplasm. Orthologous to human TRIM17 (tripartite motif containing 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 63.4), whole brain E14.5 (RPKM 20.0) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 36.38 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58845511..58863923)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58954671..58973075)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3954 Neighboring gene STARR-positive B cell enhancer ABC_E114 Neighboring gene predicted gene, 51864 Neighboring gene STARR-positive B cell enhancer ABC_E5230 Neighboring gene STARR-positive B cell enhancer ABC_E6989 Neighboring gene RIKEN cDNA 2310058D17 gene Neighboring gene H2B clustered histone 27 Neighboring gene H2B clustered histone 26 Neighboring gene H2A clustered histone 25 Neighboring gene STARR-seq mESC enhancer starr_29613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58796334-58796535 Neighboring gene H3.4 histone, cluster member Neighboring gene tripartite motif-containing 11 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene predicted gene 10435

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis. Lassot I, et al. Cell Death Differ, 2010 Dec. PMID 20559321, Free PMC Article
  2. Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. Ogawa S, et al. Cytogenet Cell Genet, 2000. PMID 10894938
  3. Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17. Mojsa B, et al. Cell Death Differ, 2015 Feb. PMID 25215946, Free PMC Article
  4. TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. Urano T, et al. Biochem Biophys Res Commun, 2009 May 29. PMID 19358823
  5. Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons. Magiera MM, et al. Cell Death Differ, 2013 Feb. PMID 22976837, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis
    Title: Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.
  2. Trim17 contributes to the ubiquitination and the proteasomal degradation of Mcl-1 in neurons.
    Title: Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons.
  3. Overexpression and silencing data indicate that Trim17 is necessary and sufficient for inducing the Bax-dependent intrinsic pathway of neuronal apoptosis and that its pro-apoptotic effect depends on its E3 activity.
    Title: Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis.
  4. terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein.
    Title: TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM17
Names
RING-type E3 ubiquitin transferase TRIM17
ring finger protein 16
tripartite motif protein 17
tripartite motif protein TRIM17
tripartite motif-containing protein 17
NP_112449.1
XP_006533874.1
XP_006533875.1
XP_011247459.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031172.3 → NP_112449.1  E3 ubiquitin-protein ligase TRIM17

    See identical proteins and their annotated locations for NP_112449.1

    Status: VALIDATED

    Source sequence(s)
    AL662809, BC055112
    Consensus CDS
    CCDS24756.1
    UniProtKB/Swiss-Prot
    A2AB82, Q7TPM3, Q99PP8
    Related
    ENSMUSP00000074639.7, ENSMUST00000075141.7
    Conserved Domains (4) summary
    PTZ00121
    Location:64 → 271
    PTZ00121; MAEBL; Provisional
    cd15812
    Location:296 → 472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd19762
    Location:98 → 139
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:13 → 66
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58845511..58863923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249157.4 → XP_011247459.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_011247459.1

    UniProtKB/Swiss-Prot
    A2AB82, Q7TPM3, Q99PP8
    Conserved Domains (4) summary
    PTZ00121
    Location:64 → 271
    PTZ00121; MAEBL; Provisional
    cd15812
    Location:296 → 472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd19762
    Location:98 → 139
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:13 → 66
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_006533811.4 → XP_006533874.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_006533874.1

    UniProtKB/Swiss-Prot
    A2AB82, Q7TPM3, Q99PP8
    Conserved Domains (4) summary
    PTZ00121
    Location:64 → 271
    PTZ00121; MAEBL; Provisional
    cd15812
    Location:296 → 472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd19762
    Location:98 → 139
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:13 → 66
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_006533812.5 → XP_006533875.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

    See identical proteins and their annotated locations for XP_006533875.1

    UniProtKB/Swiss-Prot
    A2AB82, Q7TPM3, Q99PP8
    Conserved Domains (4) summary
    PTZ00121
    Location:64 → 271
    PTZ00121; MAEBL; Provisional
    cd15812
    Location:296 → 472
    SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
    cd19762
    Location:98 → 139
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:13 → 66
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPM3.1 GenPept UniProtKB/Swiss-Prot:Q7TPM3

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