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Poll polymerase (DNA directed), lambda [ Mus musculus (house mouse) ]

Gene ID: 56626, updated on 21-Apr-2024

Summary

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Official Symbol
Pollprovided by MGI
Official Full Name
polymerase (DNA directed), lambdaprovided by MGI
Primary source
MGI:MGI:1889000
See related
Ensembl:ENSMUSG00000025218 AllianceGenome:MGI:1889000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110003P06Rik
Summary
Enables DNA-directed DNA polymerase activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within DNA replication and cellular response to DNA damage stimulus. Predicted to be located in nucleoplasm. Predicted to be active in nucleus and site of double-strand break. Is expressed in muscle tissue; retina; and seminiferous tubule. Orthologous to human POLL (DNA polymerase lambda). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 24.9), ovary adult (RPKM 5.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 38.75 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45540714..45549025, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45552275..45560564, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene beta-transducin repeat containing protein Neighboring gene ribosomal protein L6 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45602595-45602796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45634643-45634844 Neighboring gene STARR-positive B cell enhancer ABC_E9999 Neighboring gene predicted gene, 41856 Neighboring gene predicted gene, 19639 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45652022-45652175 Neighboring gene deleted in primary ciliary dyskinesia Neighboring gene AmnSINE1 enhancer AS071 Neighboring gene F-box and WD-40 domain protein 4 Neighboring gene STARR-seq mESC enhancer starr_46281 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45758150-45758404 Neighboring gene CR4 enhancer downstream of Fgf8 Neighboring gene RIKEN cDNA 4933429K18 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DNA polymerases β and λ and their roles in cell. Belousova EA, et al. DNA Repair (Amst), 2015 May. PMID 25715666
  2. Structure-function studies of DNA polymerase λ. Bebenek K, et al. Biochemistry, 2014 May 6. PMID 24716527, Free PMC Article
  3. A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesions. Markkanen E, et al. Proc Natl Acad Sci U S A, 2012 Dec 11. PMID 23175785, Free PMC Article
  4. Deployment of DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair. Thapar U, et al. DNA Repair (Amst), 2019 Apr. PMID 30763888, Free PMC Article
  5. Essential role for polymerase specialization in cellular nonhomologous end joining. Pryor JM, et al. Proc Natl Acad Sci U S A, 2015 Aug 18. PMID 26240371, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair
    Title: Deployment of DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair.
  2. Pol mu and Pol lambda play a key role in conferring on NHEJ the flexibility required for accurate and efficient repair
    Title: Essential role for polymerase specialization in cellular nonhomologous end joining.
  3. Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM) with no effect on mutation specificity, suggesting no direct role in SHM.
    Title: DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.
  4. both pol lambda and pol beta interact with the upstream DNA glycosylases for repair of alkylated and oxidized DNA bases
    Title: DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts.
  5. analysis of the interaction between DNA Polymerase lambda and anticancer nucleoside analogs
    Title: Interaction between DNA Polymerase lambda and anticancer nucleoside analogs.
  6. Pol lambda contributes to base excision repair in mouse fibroblast cell extract.
    Title: DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts.
  7. Pol lambda is not required for normal Ig gene hypermutation.
    Title: Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.
  8. Pol lambda protects cells against oxidative stress, and participates in oxidative DNA damage base excision repair.
    Title: DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair.
  9. Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
    Title: Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
  10. third hypervariable region assumes for each immunoglobulin chain, with pol lambda maintaining a large heavy chain junctional heterogeneity and pol mu ensuring a restricted light chain junctional variability
    Title: Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-deoxyribose-5-phosphate lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed DNA polymerase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA biosynthetic process ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within base-excision repair, gap-filling ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in base-excision repair, gap-filling ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA polymerase lambda
Names
pol Lambda
NP_001317435.1
NP_001317436.1
NP_064416.1
XP_036017537.1
XP_036017538.1
XP_036017539.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330506.1 → NP_001317435.1  DNA polymerase lambda isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC126454, AK003392, BE949923, BG080424, BY270661
    Consensus CDS
    CCDS29861.1
    UniProtKB/Swiss-Prot
    Q9CTJ1, Q9QXE2

  2. NM_001330507.1 → NP_001317436.1  DNA polymerase lambda isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK003392, AK133087, BE949923, BG080424, BY270661, BY315476
    UniProtKB/Swiss-Prot
    Q9QXE2

  3. NM_020032.3 → NP_064416.1  DNA polymerase lambda isoform 1

    See identical proteins and their annotated locations for NP_064416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK003392, BE949923, BG080424, BY270661, BY315476
    Consensus CDS
    CCDS29861.1
    UniProtKB/Swiss-Prot
    Q9CTJ1, Q9QXE2
    Related
    ENSMUSP00000026239.7, ENSMUST00000026239.7
    Conserved Domains (3) summary
    cd00141
    Location:253 → 571
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00483
    Location:249 → 572
    POLXc; DNA polymerase X family
    cd00027
    Location:56 → 119
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    45540714..45549025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161644.1 → XP_036017537.1  DNA polymerase lambda isoform X1

    Conserved Domains (3) summary
    cd00141
    Location:253 → 580
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    PHA03247
    Location:134 → 231
    PHA03247; large tegument protein UL36; Provisional
    cd17715
    Location:40 → 123
    BRCT_polymerase_lambda; BRCT domain of DNA polymerase lambda and similar proteins

  2. XM_036161646.1 → XP_036017539.1  DNA polymerase lambda isoform X1

    Conserved Domains (3) summary
    cd00141
    Location:253 → 580
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    PHA03247
    Location:134 → 231
    PHA03247; large tegument protein UL36; Provisional
    cd17715
    Location:40 → 123
    BRCT_polymerase_lambda; BRCT domain of DNA polymerase lambda and similar proteins

  3. XM_036161645.1 → XP_036017538.1  DNA polymerase lambda isoform X1

    Conserved Domains (3) summary
    cd00141
    Location:253 → 580
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    PHA03247
    Location:134 → 231
    PHA03247; large tegument protein UL36; Provisional
    cd17715
    Location:40 → 123
    BRCT_polymerase_lambda; BRCT domain of DNA polymerase lambda and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXE2.1 GenPept UniProtKB/Swiss-Prot:Q9QXE2

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