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Rps6ka4 ribosomal protein S6 kinase, polypeptide 4 [ Mus musculus (house mouse) ]

Gene ID: 56613, updated on 5-Mar-2024

Summary

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Official Symbol
Rps6ka4provided by MGI
Official Full Name
ribosomal protein S6 kinase, polypeptide 4provided by MGI
Primary source
MGI:MGI:1930076
See related
Ensembl:ENSMUSG00000118668 AllianceGenome:MGI:1930076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msk2; 90kDa; mMSK2; 1110069D02Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including histone-serine phosphorylation; interleukin-1-mediated signaling pathway; and positive regulation of histone modification. Predicted to act upstream of or within inflammatory response and phosphorylation. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in 1st branchial arch maxillary component; heart; maxillary process; and sensory organ. Orthologous to human RPS6KA4 (ribosomal protein S6 kinase A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 18.4), adrenal adult (RPKM 18.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 5.08 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6806573..6819513, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6829084..6842145, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32245 Neighboring gene high mobility group box 1, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_45439 Neighboring gene STARR-seq mESC enhancer starr_45441 Neighboring gene microRNA 5046 Neighboring gene coiled-coil domain containing 88B Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6946569-6946770 Neighboring gene predicted gene, 54051

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparison of epigenetic mediator expression and function in mouse and human embryonic blastomeres. Chavez SL, et al. Hum Mol Genet, 2014 Sep 15. PMID 24821703, Free PMC Article
  2. Construction of a conditional allele of RSK-B/MSK2 in the mouse. Casanova E, et al. Genesis, 2002 Feb. PMID 11857808
  3. The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development. Bhat N, et al. PLoS One, 2016. PMID 27973548, Free PMC Article
  4. Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2. Lang E, et al. Sci Rep, 2015 Nov 27. PMID 26611568, Free PMC Article
  5. Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis. Karelina K, et al. Neuroscience, 2015 Jan 29. PMID 25451279, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. regulator of nucleosomal remodelling in the diabetic milieu
    Title: miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy.
  2. chromatin modifier, MSK1/2, has a role in suppressing endocrine and promoting acinar differentiation during pancreatic development
    Title: The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.
  3. Accelerated apoptotic death and in vivo turnover of erythrocytes have been found in mice lacking functional MSK1/MSK2.
    Title: Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.
  4. Results suggest that MSK1/2 plays a significant role in the regulation of ischemia-induced progenitor cell proliferation and neurogenesis
    Title: Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis.
  5. MSK1/2 knockout results in reduced IL-10 secretion.
    Title: MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop.
  6. data reveal a critical role for MSK1/2 as regulators of both basal and activity-dependent progenitor cell proliferation and morphological maturation in the subgranular zone
    Title: Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus.
  7. Comparison of the effects of SB-747651A, both in vitro and in cells, demonstrated that SB-747651A exhibited improved selectivity over H89 and Ro 31-8220 and therefore represents a useful tool to study MSK function in cells.
    Title: Characterization of the cellular action of the MSK inhibitor SB-747651A.
  8. MSK1/2 are involved in the activation of feedback mechanisms that dampen oxazolone-induced skin inflammation.
    Title: The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice.
  9. These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.
    Title: Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.
  10. MSK1/2 regulate pri-miR-212/132 transcription via the phosphorylation of CREB.
    Title: Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3S10 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3S28 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribosomal protein S6 kinase alpha-4
Names
90 kDa ribosomal protein S6 kinase 4
RLSK
RSK-like protein kinase
S6K-alpha-4
mitogen- and stress-activated protein kinase-2
nuclear mitogen- and stress-activated protein kinase 2
ribosomal protein S6 kinase, 90kD, polypeptide 4
NP_064308.2
XP_017173750.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019924.2 → NP_064308.2  ribosomal protein S6 kinase alpha-4

    See identical proteins and their annotated locations for NP_064308.2

    Status: VALIDATED

    Source sequence(s)
    AC120557, AK089467, BF465098, BP759267, CF616720, CJ065157
    Consensus CDS
    CCDS37899.1
    UniProtKB/Swiss-Prot
    Q3U3M8, Q91X18, Q9Z2B9
    Related
    ENSMUSP00000159422.2, ENSMUST00000239527.1
    Conserved Domains (3) summary
    smart00220
    Location:33 → 301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05614
    Location:32 → 364
    STKc_MSK2_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2
    cd14180
    Location:404 → 714
    STKc_MSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6806573..6819513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318261.3 → XP_017173750.1  ribosomal protein S6 kinase alpha-4 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 301
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004940158.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2B9.2 GenPept UniProtKB/Swiss-Prot:Q9Z2B9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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