Pfdn5 prefoldin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pfdn5provided by MGI
Official Full Name: prefoldin 5provided by MGI
Primary source: MGI:MGI:1928753
See related: Ensembl:ENSMUSG00000001289 AllianceGenome:MGI:1928753
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eig1; MM-1; D15Ertd697e; 1190001O17Rik; 1700010A06Rik
Summary: Predicted to enable amyloid-beta binding activity and unfolded protein binding activity. Acts upstream of or within retina development in camera-type eye. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in brain; genitourinary system; gut gland; and trachea. Orthologous to human PFDN5 (prefoldin subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 164.4), testis adult (RPKM 156.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.48 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (102234551..102239925)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102326116..102331490)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus.
Title: Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus.
a genetic disruption in the murine Pfdn5 gene, a subunit of prefoldin, causes a syndrome characterized by photoreceptor degeneration, central nervous system abnormalities, and male infertility
Title: Prefoldin 5 is required for normal sensory and neuronal development in a murine model.
MM-1 may play a role in liver development and growth.
Title: Molecular cloning, expression and chromosomal localization of mouse MM-1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Chemically induced (ENU) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Ertd697e (e-PCR), detects polymorphism
- UniSTS:167175

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA polymerase I assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II core complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase III assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of prefoldin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prefoldin subunit 5

Names: C-myc-binding protein Mm-1; EIG-1; c-myc binding protein MM-1; myc modulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027044.3 → NP_081320.2 prefoldin subunit 5

See identical proteins and their annotated locations for NP_081320.2

Status: VALIDATED

Source sequence(s)

AF108357, CN835522

Consensus CDS

CCDS37227.1

UniProtKB/Swiss-Prot

Q3UKS8, Q9JMJ8, Q9WU28

UniProtKB/TrEMBL

Q6ZWY7

Related

ENSMUSP00000129178.2, ENSMUST00000166658.8

Conserved Domains (1) summary

TIGR00293
Location:12 → 138

TIGR00293; prefoldin, archaeal alpha subunit/eukaryotic subunit 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

102234551..102239925

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_020031.1: Suppressed sequence

Description

NM_020031.1: This RefSeq was permanently suppressed because it was based on a chimeric source sequence (AB011473.1), and the N-terminus of the encoded protein is not supported.