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Ube2d2a ubiquitin-conjugating enzyme E2D 2A [ Mus musculus (house mouse) ]

Gene ID: 56550, updated on 5-Mar-2024

Summary

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Official Symbol
Ube2d2aprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2D 2Aprovided by MGI
Primary source
MGI:MGI:1930715
See related
Ensembl:ENSMUSG00000091896 AllianceGenome:MGI:1930715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ubc4; Ubc2e; Ube2d2; 1500034D03Rik
Summary
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2D2 (ubiquitin conjugating enzyme E2 D2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 16.9), CNS E11.5 (RPKM 16.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ube2d2a in Genome Data Viewer
Location:
18 B2; 18 19.24 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35904612..35940225)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35771559..35807172)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene stimulator of interferon response cGAMP interactor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9974 Neighboring gene STARR-seq mESC enhancer starr_44249 Neighboring gene STARR-seq mESC enhancer starr_44252 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44255 Neighboring gene STARR-seq mESC enhancer starr_44256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:35991804-35992030 Neighboring gene predicted gene 29417 Neighboring gene VISTA enhancer mm1664 Neighboring gene CXXC finger 5 Neighboring gene STARR-positive B cell enhancer mm9_chr18:36003985-36004286 Neighboring gene VISTA enhancer mm1614 Neighboring gene STARR-positive B cell enhancer ABC_E1206 Neighboring gene predicted gene, 41693

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility. Bedard N, et al. Mol Cell Biol, 2005 Aug. PMID 16024774, Free PMC Article
  2. RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity. McKelvey AC, et al. Elife, 2016 Nov 2. PMID 27805901, Free PMC Article
  3. Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons. Magiera MM, et al. Cell Death Differ, 2013 Feb. PMID 22976837, Free PMC Article
  4. Physical and functional interactions between ZIP kinase and UbcH5. Ohbayashi N, et al. Biochem Biophys Res Commun, 2008 Aug 8. PMID 18515077
  5. Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction. Lu Z, et al. J Cell Biol, 2007 Jun 18. PMID 17576800, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 D2
Names
(E3-independent) E2 ubiquitin-conjugating enzyme D2
E2 ubiquitin-conjugating enzyme D2
E2(17)KB 2
ubiquitin carrier protein D2
ubiquitin conjugating enzyme 2e
ubiquitin-conjugating enzyme E2(17)KB 2
ubiquitin-conjugating enzyme E2-17 kDa 2
ubiquitin-conjugating enzyme E2D 2
ubiquitin-protein ligase D2
NP_064296.1
XP_006526183.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019912.2 → NP_064296.1  ubiquitin-conjugating enzyme E2 D2

    See identical proteins and their annotated locations for NP_064296.1

    Status: VALIDATED

    Source sequence(s)
    AK147568, AK148089, BE688817, BY136374
    Consensus CDS
    CCDS50254.1
    UniProtKB/Swiss-Prot
    P62838
    UniProtKB/TrEMBL
    Q3U5V6, Q3UT95, Q9D1S1
    Related
    ENSMUSP00000132446.2, ENSMUST00000170693.9
    Conserved Domains (1) summary
    cl00154
    Location:1 → 146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35904612..35940225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526120.4 → XP_006526183.1  ubiquitin-conjugating enzyme E2 D2 isoform X1

    See identical proteins and their annotated locations for XP_006526183.1

    UniProtKB/TrEMBL
    Q9D1S1
    Conserved Domains (1) summary
    cl00154
    Location:1 → 117
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62838.1 GenPept UniProtKB/Swiss-Prot:P62838

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