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Sec1 secretory blood group 1 [ Mus musculus (house mouse) ]

Gene ID: 56546, updated on 25-Apr-2024

Summary

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Official Symbol
Sec1provided by MGI
Official Full Name
secretory blood group 1provided by MGI
Primary source
MGI:MGI:1928893
See related
Ensembl:ENSMUSG00000040364 AllianceGenome:MGI:1928893
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fut3; Fut10
Summary
This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. This gene is predicted to encode a type II membrane protein, which is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. [provided by RefSeq, Dec 2012]
Expression
Biased expression in testis adult (RPKM 22.6), colon adult (RPKM 8.4) and 4 other tissues See more
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Genomic context

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Location:
7 B3; 7 29.43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45327110..45343825, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45677686..45694402, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335 Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene fucosyltransferase 2 Neighboring gene predicted gene, 39008 Neighboring gene netrin 5 Neighboring gene STARR-positive B cell enhancer ABC_E350 Neighboring gene carbonic anhydrase 11 Neighboring gene D site albumin promoter binding protein Neighboring gene sphingosine kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota. Ren Z, et al. Genes (Basel), 2022 Oct 14. PMID 36292744, Free PMC Article
  2. Insight into mechanisms of pig lncRNA FUT3-AS1 regulating E. coli F18-bacterial diarrhea. Wu Z, et al. PLoS Pathog, 2022 Jun. PMID 35696408, Free PMC Article
  3. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Esposito M, et al. Nat Cell Biol, 2019 May. PMID 30988423, Free PMC Article
  4. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse. Baboval T, et al. Mamm Genome, 2002 Sep. PMID 12370785
  5. GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II, and not MFUT-I or -III, is induced in a restricted region of the digestive tract of germ-free mice by host-microbe interactions and cycloheximide. Lin B, et al. Biochim Biophys Acta, 2000 Sep 27. PMID 11018479

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease.
    Title: Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease.
  2. Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota.
    Title: Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota.
  3. E-selectin binding activity mediated by the alpha1-3 fucosyltransferases Fut3/Fut6 and Glg1 are instrumental to the formation of bone metastasis. These findings provide unique insights into the functional role of E-selectin as a component of the vascular niche critical for metastatic colonization in bone.
    Title: Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis.
  4. amino acid sequence and expression
    Title: Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactoside 2-alpha-L-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactoside 2-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galactoside 2-alpha-L-fucosyltransferase Sec1
Names
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 3
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase FUT-III
alpha(1,2)FT 3
fucosyltransferase 10
galactoside 2-alpha-L-fucosyltransferase 3
NP_001258507.1
NP_001392824.1
XP_006541073.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271578.2 → NP_001258507.1  galactoside 2-alpha-L-fucosyltransferase Sec1

    See identical proteins and their annotated locations for NP_001258507.1

    Status: VALIDATED

    Source sequence(s)
    AC167242
    Consensus CDS
    CCDS71963.1
    UniProtKB/TrEMBL
    Q496T8, Q8CDC9
    Related
    ENSMUSP00000045229.7, ENSMUST00000040636.9
    Conserved Domains (1) summary
    pfam01531
    Location:55 → 362
    Glyco_transf_11; Glycosyl transferase family 11

  2. NM_001405895.1 → NP_001392824.1  galactoside 2-alpha-L-fucosyltransferase Sec1

    Status: VALIDATED

    Source sequence(s)
    AC167242
    UniProtKB/TrEMBL
    Q8CDC9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45327110..45343825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541010.4 → XP_006541073.1  galactoside 2-alpha-L-fucosyltransferase Sec1 isoform X2

    UniProtKB/TrEMBL
    Q496T8
    Conserved Domains (1) summary
    pfam01531
    Location:4 → 277
    Glyco_transf_11; Glycosyl transferase family 11

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019934.2: Suppressed sequence

    Description
    NM_019934.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97353.1 GenPept UniProtKB/Swiss-Prot:P97353

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