Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnd3provided by MGI
Official Full Name: potassium voltage-gated channel, Shal-related family, member 3provided by MGI
Primary source: MGI:MGI:1928743
See related: Ensembl:ENSMUSG00000040896 AllianceGenome:MGI:1928743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kncd3; Kv4.3
Summary: Enables voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization. Acts upstream of or within cardiac conduction; cardiac muscle cell action potential involved in contraction; and potassium ion export across plasma membrane. Located in membrane. Is integral component of postsynaptic specialization membrane. Is active in GABA-ergic synapse. Is expressed in heart and heart ventricle. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 8.1), cerebellum adult (RPKM 6.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 46.32 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (105359206..105581318)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (105451890..105674002)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of the A-type potassium current in murine gastric fundus smooth muscles.
Title: Characterization of the A-type potassium current in murine gastric fundus smooth muscles.
In ERaKO but not ERaKO mice, the mRNA of Kv4.3 was selectively increased... E2 negatively regulates the density of Ito through ERa, this highlights a potential role for this female hormone in modulating cardiac electrical activity.
Title: Estrogen regulation of the transient outward K(+) current involves estrogen receptor α in mouse heart.
Data show that potassium channel Kv4.3 outward current is presented incardiomyocyte lacking the potassium channel Kv4.2 gene (Kv4.2-/-).
Title: Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.
The gain-of-function SCNA overexpressing dopamine substantia nigra neurons was in part mediated by an increase of their intrinsic pacemaker frequency caused by a redox-dependent impairment of Kv4.3
Title: Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels.
The protein levels of KV4.3 and KV2.2 were up-regulated in the hypertrophic smooth muscle cell membrane.
Title: Voltage dependent potassium channel remodeling in murine intestinal smooth muscle hypertrophy induced by partial obstruction.
The experiments here demonstrate that Kv4.2, Kv4.3 and Kv1.4 all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles in regulating the intrinsic properties of mature CP neurons.
Title: A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.
Taken together, these data suggest that nerve injury causes an epigenetic silencing of K(v)4.3 gene mediated through transcriptional suppressor NRSF in the DRG.
Title: Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury.
Kv4.3 channel alpha-subunit is found to be one of the components (along with Kv4.2 and Kv1.4) that propagates the voltage-gated potassium current in pyramidal cortical neurons.
Title: Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits.
Downregulation of Kv4.3 and Kv1.5 transcripts by estrogen are one mechanism defining gender-related differences in mouse ventricular repolarization.
Title: Estrogen contributes to gender differences in mouse ventricular repolarization.
N-terminal binding of Kv4.3 to the core of KChIP4a mobilizes the KChIP4a N terminus, which serves as the slow inactivation gate.
Title: Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW045978 (e-PCR)
- UniSTS:165284

PMC125678P3 (e-PCR)
- UniSTS:270506

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables A-type (transient outward) potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to A-type (transient outward) potassium channel activity	ISO Inferred from Sequence Orthology more info
enables A-type (transient outward) potassium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily D member 3

Names: potassium channel Kv4.3L; potassium channel Kv4.3M; voltage-gated potassium channel subunit Kv4.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039347.2 → NP_001034436.1 potassium voltage-gated channel subfamily D member 3 isoform 1

See identical proteins and their annotated locations for NP_001034436.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

AC123041, AC123847, AC139316

Consensus CDS

CCDS17708.1

UniProtKB/TrEMBL

Q3UH54

Related

ENSMUSP00000096357.4, ENSMUST00000098761.10

Conserved Domains (6) summary

smart00225
Location:42 → 139

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:217 → 412

Ion_trans; Ion transport protein

pfam02214
Location:42 → 131

BTB_2; BTB/POZ domain

pfam07885
Location:328 → 408

Ion_trans_2; Ion channel

pfam11601
Location:3 → 28

Shal-type; Shal-type voltage-gated potassium channels

pfam11879
Location:442 → 544

DUF3399; Domain of unknown function (DUF3399)
NM_019931.2 → NP_064315.1 potassium voltage-gated channel subfamily D member 3 isoform 2

See identical proteins and their annotated locations for NP_064315.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a shorter C-terminus, compared to isoform 1.

Source sequence(s)

AC123041, AC123847, AC139316

Consensus CDS

CCDS17709.1

UniProtKB/Swiss-Prot

Q8CC44, Q9Z0V0, Q9Z0V1

UniProtKB/TrEMBL

B2RUE0

Related

ENSMUSP00000078169.5, ENSMUST00000079169.5

Conserved Domains (3) summary

cd18419
Location:6 → 143

BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)

pfam00520
Location:182 → 412

Ion_trans; Ion transport protein

pfam11879
Location:442 → 563

DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

105359206..105581318

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163174.1 → XP_036019067.1 potassium voltage-gated channel subfamily D member 3 isoform X2

Conserved Domains (2) summary

cd18419
Location:6 → 143

BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)

pfam00520
Location:186 → 369

Ion_trans; Ion transport protein
XM_030252699.2 → XP_030108559.1 potassium voltage-gated channel subfamily D member 3 isoform X1

UniProtKB/Swiss-Prot

Q8CC44, Q9Z0V0, Q9Z0V1

UniProtKB/TrEMBL

B2RUE0

Conserved Domains (3) summary

cd18419
Location:6 → 143

BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)

pfam00520
Location:182 → 412

Ion_trans; Ion transport protein

pfam11879
Location:442 → 563

DUF3399; Domain of unknown function (DUF3399)