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Habp4 hyaluronic acid binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 56541, updated on 11-Apr-2024

Summary

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Official Symbol
Habp4provided by MGI
Official Full Name
hyaluronic acid binding protein 4provided by MGI
Primary source
MGI:MGI:1891713
See related
Ensembl:ENSMUSG00000021476 AllianceGenome:MGI:1891713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933413D03Rik; 4933428J01Rik
Summary
Predicted to enable RNA binding activity; SUMO binding activity; and hyaluronic acid binding activity. Predicted to be involved in several processes, including PML body organization; cellular response to mechanical stimulus; and positive regulation of gene expression. Predicted to act upstream of or within hyaluronan metabolic process. Located in cytoplasm. Is expressed in central nervous system; ovary; retina; and white fat. Orthologous to human HABP4 (hyaluronan binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 67.5), cortex adult (RPKM 46.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 B3; 13 33.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64309680..64334351)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64161866..64186537)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member D2 Neighboring gene zinc finger protein 367 Neighboring gene STARR-seq mESC enhancer starr_34820 Neighboring gene STARR-positive B cell enhancer ABC_E5404 Neighboring gene STARR-positive B cell enhancer ABC_E928 Neighboring gene STARR-positive B cell enhancer ABC_E7250 Neighboring gene CDC14 cell division cycle 14B Neighboring gene STARR-seq mESC enhancer starr_34826 Neighboring gene predicted gene, 46424 Neighboring gene RIKEN cDNA 1810034E14 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Intracellular hyaluronic acid-binding protein 4 (HABP4): a candidate tumor suppressor in colorectal cancer. Melo-Hanchuk TD, et al. Oncotarget, 2020 Nov 17. PMID 33245729, Free PMC Article
  2. Molecular characterization of a novel intracellular hyaluronan-binding protein. Huang L, et al. J Biol Chem, 2000 Sep 22. PMID 10887182
  3. In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Marshall KE, et al. Genome Biol, 2002. PMID 12537567, Free PMC Article
  4. A tudor domain protein SPINDLIN1 interacts with the mRNA-binding protein SERBP1 and is involved in mouse oocyte meiotic resumption. Chew TG, et al. PLoS One, 2013. PMID 23894536, Free PMC Article
  5. Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Gogstad GO, et al. Biochim Biophys Acta, 1981 Sep 29. PMID 6457647

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO binding ISO
Inferred from Sequence Orthology
more info
  
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in PML body organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hyaluronan metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in Gemini of coiled bodies ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
intracellular hyaluronan-binding protein 4
Names
IHABP-4
IHABP4
hyaluronic acid-binding protein 4 (intracellular)
intracellular hyaluronan-binding protein p57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019986.3 → NP_064370.2  intracellular hyaluronan-binding protein 4

    Status: VALIDATED

    Source sequence(s)
    AK016800, AK146525, CD776978
    Consensus CDS
    CCDS36702.1
    UniProtKB/Swiss-Prot
    Q3UNH8, Q9D450, Q9JKS5
    UniProtKB/TrEMBL
    E9QKB2
    Related
    ENSMUSP00000021929.9, ENSMUST00000021929.10
    Conserved Domains (2) summary
    pfam04774
    Location:212 → 315
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:16 → 131
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    64309680..64334351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKS5.2 GenPept UniProtKB/Swiss-Prot:Q9JKS5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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