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Pex3 peroxisomal biogenesis factor 3 [ Mus musculus (house mouse) ]

Gene ID: 56535, updated on 11-Apr-2024

Summary

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Official Symbol
Pex3provided by MGI
Official Full Name
peroxisomal biogenesis factor 3provided by MGI
Primary source
MGI:MGI:1929646
See related
Ensembl:ENSMUSG00000019809 AllianceGenome:MGI:1929646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700014F15Rik; 2810027F19Rik; 2900010N04Rik
Summary
Predicted to enable lipid binding activity and protein-macromolecule adaptor activity. Predicted to be involved in peroxisome membrane biogenesis and protein import into peroxisome membrane. Predicted to be located in several cellular components, including endoplasmic reticulum; nucleoplasm; and peroxisomal membrane. Predicted to be integral component of plasma membrane. Predicted to be part of protein-lipid complex. Predicted to be integral component of peroxisomal membrane. Is expressed in cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 10A. Orthologous to human PEX3 (peroxisomal biogenesis factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 24.6), bladder adult (RPKM 9.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 A2; 10 4.89 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (13399586..13428886, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13523842..13553142, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phosphatase and actin regulator 2 Neighboring gene predicted gene, 46211 Neighboring gene STARR-seq mESC enhancer starr_25813 Neighboring gene STARR-seq mESC enhancer starr_25814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13220839-13220948 Neighboring gene STARR-seq mESC enhancer starr_25815 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13272745-13273072 Neighboring gene fucosidase, alpha-L- 2, plasma Neighboring gene adenosine deaminase, tRNA-specific 2 Neighboring gene RIKEN cDNA A730010A20 gene Neighboring gene STARR-seq mESC enhancer starr_25816 Neighboring gene androgen-induced 1 Neighboring gene predicted gene, 53613

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein. Muntau AC, et al. Biol Chem, 2000 Apr. PMID 10839463
  2. The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear. Kochaj RM, et al. Cells, 2022 Oct 13. PMID 36291074, Free PMC Article
  3. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Liakath-Ali K, et al. Nat Commun, 2014 Apr 11. PMID 24721909, Free PMC Article
  4. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear.
    Title: The Effect of a Pex3 Mutation on Hearing and Lipid Content of the Inner Ear.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in peroxisome membrane biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in peroxisome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into peroxisome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into peroxisome membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein-lipid complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal biogenesis factor 3
Names
peroxin-3
peroxisomal assembly protein 3
peroxisomal assembly protein PEX3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164195.1 → NP_001157667.1  peroxisomal biogenesis factor 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC153979, AK005978, AV256241
    Consensus CDS
    CCDS48503.1
    UniProtKB/TrEMBL
    E9QA46, Q8C6F0
    Related
    ENSMUSP00000128512.2, ENSMUST00000170376.8
    Conserved Domains (1) summary
    pfam04882
    Location:11 → 345
    Peroxin-3; Peroxin-3

  2. NM_001347361.1 → NP_001334290.1  peroxisomal biogenesis factor 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC153979, AK005315, AK013522
    Consensus CDS
    CCDS83681.1
    UniProtKB/TrEMBL
    D3Z6X3, D3Z6X4
    Related
    ENSMUSP00000101178.2, ENSMUST00000105539.2

  3. NM_019961.3 → NP_064345.1  peroxisomal biogenesis factor 3 isoform 1

    See identical proteins and their annotated locations for NP_064345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC153979, AK146934, CJ299039
    Consensus CDS
    CCDS23702.1
    UniProtKB/Swiss-Prot
    Q9QXY9
    UniProtKB/TrEMBL
    Q3UIG2, Q8C6F0
    Related
    ENSMUSP00000019945.9, ENSMUST00000019945.15
    Conserved Domains (1) summary
    pfam04882
    Location:11 → 361
    Peroxin-3; Peroxin-3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    13399586..13428886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXY9.1 GenPept UniProtKB/Swiss-Prot:Q9QXY9

Gene LinkOut

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