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Ylpm1 YLP motif containing 1 [ Mus musculus (house mouse) ]

Gene ID: 56531, updated on 5-Mar-2024

Summary

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Official Symbol
Ylpm1provided by MGI
Official Full Name
YLP motif containing 1provided by MGI
Primary source
MGI:MGI:1926195
See related
Ensembl:ENSMUSG00000021244 AllianceGenome:MGI:1926195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZAP; Zap3; A930013E17Rik
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of telomere maintenance. Located in nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and immune system. Orthologous to human YLPM1 (YLP motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 14.2), CNS E11.5 (RPKM 12.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 39.5 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85042977..85130501)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84996203..85088068)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86311736-86311923 Neighboring gene FCF1 rRNA processing protein Neighboring gene STARR-positive B cell enhancer ABC_E1446 Neighboring gene STARR-seq mESC enhancer starr_32760 Neighboring gene STARR-seq mESC enhancer starr_32761 Neighboring gene STARR-seq mESC enhancer starr_32762 Neighboring gene prospero homeobox 2 opposite strand Neighboring gene prospero homeobox 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86464102-86464289 Neighboring gene dihydrolipoamide S-succinyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The efficacy of zinc finger antiviral protein against hepatitis B virus transcription and replication in tansgenic mouse model. Chen EQ, et al. Virol J, 2015 Feb 13. PMID 25889209, Free PMC Article
  2. NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines. Peeraully MR, et al. Am J Physiol Endocrinol Metab, 2004 Aug. PMID 15100092
  3. A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Armstrong L, et al. Mech Dev, 2004 Dec. PMID 15511642
  4. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Misawa K, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10716735, Free PMC Article
  5. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZAP inhibited hepatitis B virus replication in vivo.
    Title: The efficacy of zinc finger antiviral protein against hepatitis B virus transcription and replication in tansgenic mouse model.
  2. Overexpression in murine embryonic stem cells results in reduction in telomerase activity and reduced cell division.
    Title: A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of telomere maintenance IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
YLP motif-containing protein 1
Names
nuclear protein ZAP
nuclear protein ZAP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347421.1 → NP_001334350.1  YLP motif-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AC127582, AC155811, AK044440, AK087500, BF464857, BM947342, CA328677, CF747026, CR974585
    Consensus CDS
    CCDS88371.1
    UniProtKB/Swiss-Prot
    E9QKY3, Q7TMM4, Q9R0I7
    UniProtKB/TrEMBL
    E9Q803
    Related
    ENSMUSP00000128962.2, ENSMUST00000168977.8

  2. NM_178363.4 → NP_848140.3  YLP motif-containing protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC127582, AC155811, AK044440, AW537032, CF742131, CF747026, CR974585, CV561380
    Consensus CDS
    CCDS49114.1
    UniProtKB/TrEMBL
    D3YWX2
    Related
    ENSMUSP00000021670.9, ENSMUST00000021670.15
    Conserved Domains (1) summary
    pfam13671
    Location:1829 → 1968
    AAA_33; AAA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    85042977..85130501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516100.4 → XP_006516163.1  YLP motif-containing protein 1 isoform X1

    Conserved Domains (2) summary
    PRK12678
    Location:1081 → 1363
    PRK12678; transcription termination factor Rho; Provisional
    pfam13671
    Location:1798 → 1937
    AAA_33; AAA domain

RNA

  1. XR_003950069.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0I7.2 GenPept UniProtKB/Swiss-Prot:Q9R0I7

Gene LinkOut

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