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Sec11a SEC11 homolog A, signal peptidase complex subunit [ Mus musculus (house mouse) ]

Gene ID: 56529, updated on 11-Apr-2024

Summary

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Official Symbol
Sec11aprovided by MGI
Official Full Name
SEC11 homolog A, signal peptidase complex subunitprovided by MGI
Primary source
MGI:MGI:1929464
See related
Ensembl:ENSMUSG00000025724 AllianceGenome:MGI:1929464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
18kDa; Spc18; Sec11l1; sid2895; Sid2895p; 1810012E07Rik
Summary
Predicted to enable peptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; cranium; genitourinary system; integumental system; and nervous system. Orthologous to human SEC11A (SEC11 homolog A, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 78.7), limb E14.5 (RPKM 45.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sec11a in Genome Data Viewer
Location:
7 D3; 7 45.71 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80565125..80597295, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80915379..80947550, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32112 Neighboring gene WD repeat domain 73 Neighboring gene neuromedin B Neighboring gene predicted gene, 51451 Neighboring gene STARR-positive B cell enhancer ABC_E2829 Neighboring gene STARR-seq mESC enhancer starr_19348 Neighboring gene predicted gene, 32178 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene zinc finger protein 592

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  3. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal peptidase complex catalytic subunit SEC11A
Names
SEC11-like protein 1
SPase 18 kDa subunit
Sec11-like 1
endopeptidase SP18
microsomal signal peptidase 18 kDa subunit
sid 2895
signal peptidase complex (18kD)
NP_001405484.1
NP_001405485.1
NP_001405486.1
NP_001405487.1
NP_001405488.1
NP_064335.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418555.1 → NP_001405484.1  signal peptidase complex catalytic subunit SEC11A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123744

  2. NM_001418556.1 → NP_001405485.1  signal peptidase complex catalytic subunit SEC11A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123744
    UniProtKB/TrEMBL
    D3Z569
    Related
    ENSMUSP00000113601.2, ENSMUST00000117383.8

  3. NM_001418557.1 → NP_001405486.1  signal peptidase complex catalytic subunit SEC11A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123744

  4. NM_001418558.1 → NP_001405487.1  signal peptidase complex catalytic subunit SEC11A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123744

  5. NM_001418559.1 → NP_001405488.1  signal peptidase complex catalytic subunit SEC11A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123744

  6. NM_019951.2 → NP_064335.1  signal peptidase complex catalytic subunit SEC11A isoform 1

    See identical proteins and their annotated locations for NP_064335.1

    Status: VALIDATED

    Source sequence(s)
    AC123744
    Consensus CDS
    CCDS21401.1
    UniProtKB/Swiss-Prot
    Q9R0P6
    UniProtKB/TrEMBL
    D3YWT0
    Related
    ENSMUSP00000026818.6, ENSMUST00000026818.12
    Conserved Domains (1) summary
    cl10465
    Location:38 → 150
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80565125..80597295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0P6.1 GenPept UniProtKB/Swiss-Prot:Q9R0P6

Gene LinkOut

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