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Zfp235 zinc finger protein 235 [ Mus musculus (house mouse) ]

Gene ID: 56525, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp235provided by MGI
Official Full Name
zinc finger protein 235provided by MGI
Primary source
MGI:MGI:1929117
See related
Ensembl:ENSMUSG00000047603 AllianceGenome:MGI:1929117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610030O19Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in metanephros and testis. Orthologous to human ZNF235 (zinc finger protein 235). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 2.5), cerebellum adult (RPKM 2.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 10.27 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (23830452..23842669)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24132372..24143244)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18250 Neighboring gene zinc finger protein 180 Neighboring gene zinc finger protein 112 Neighboring gene STARR-positive B cell enhancer ABC_E2817 Neighboring gene STARR-seq mESC enhancer starr_18251 Neighboring gene zinc finger protein 114 Neighboring gene zinc finger protein 111

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC107482

General protein information

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Preferred Names
zinc finger protein 235

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360465.1 → NP_001347394.1  zinc finger protein 235 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC138791, AK147833
    Conserved Domains (4) summary
    COG5048
    Location:355 → 696
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:685 → 768
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:411 → 431
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 48
    KRAB; KRAB box

  2. NM_019941.3 → NP_064325.2  zinc finger protein 235 isoform 2

    See identical proteins and their annotated locations for NP_064325.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC138791
    Consensus CDS
    CCDS39825.1
    UniProtKB/TrEMBL
    Q499D5
    Conserved Domains (4) summary
    COG5048
    Location:285 → 626
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:615 → 698
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:341 → 361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 48
    KRAB; KRAB box

RNA

  1. NR_153441.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC138791, AK045726

  2. NR_153442.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC138791, AK139127

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    23830452..23842669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153273.1 → XP_036009166.1  zinc finger protein 235 isoform X2

    UniProtKB/TrEMBL
    Q499D5
    Related
    ENSMUSP00000050803.8, ENSMUST00000056549.9
    Conserved Domains (4) summary
    COG5048
    Location:285 → 626
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:615 → 698
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:341 → 361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 48
    KRAB; KRAB box

  2. XM_036153272.1 → XP_036009165.1  zinc finger protein 235 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:316 → 657
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:646 → 729
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:39 → 79
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version

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