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Pals2 protein associated with LIN7 2, MAGUK family member [ Mus musculus (house mouse) ]

Gene ID: 56524, updated on 21-Apr-2024

Summary

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Official Symbol
Pals2provided by MGI
Official Full Name
protein associated with LIN7 2, MAGUK family memberprovided by MGI
Primary source
MGI:MGI:1927340
See related
Ensembl:ENSMUSG00000038388 AllianceGenome:MGI:1927340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpp6; P55t
Summary
Predicted to enable guanylate kinase activity. Located in plasma membrane. Is expressed in heart. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 14.9), CNS E11.5 (RPKM 12.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B2.3; 6 24.13 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (50087206..50176134)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (50110228..50199154)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15836 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15837 Neighboring gene STARR-seq mESC enhancer starr_15840 Neighboring gene STARR-seq mESC enhancer starr_15842 Neighboring gene predicted gene, 38805 Neighboring gene STARR-seq mESC enhancer starr_15843 Neighboring gene gasdermin E Neighboring gene STARR-positive B cell enhancer mm9_chr6:50244177-50244478 Neighboring gene STARR-seq mESC enhancer starr_15846 Neighboring gene STARR-positive B cell enhancer ABC_E8102 Neighboring gene STARR-seq mESC enhancer starr_15847 Neighboring gene oxysterol binding protein-like 3 Neighboring gene predicted gene, 52900 Neighboring gene predicted gene, 40372

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system. Saitoh Y, et al. Histochem Cell Biol, 2019 May. PMID 30357511
  2. Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine. Kamijo A, et al. Histochem Cell Biol, 2016 Jan. PMID 26496923
  3. Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS. Terada N, et al. Histochem Cell Biol, 2013 Aug. PMID 23306908
  4. Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves. Terada N, et al. Mol Cell Biol, 2012 Jan. PMID 22025680, Free PMC Article
  5. Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells. Van Laer L, et al. Neurobiol Dis, 2005 Aug. PMID 16023581

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicate that the MPP6-Lin7 complex regulates myelin formation.
    Title: The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system.
  2. This paper herein showed the immunolocalization and interaction proteins of MPP6 in the mouse small intestine, and also that 4.1B in epithelial cells was not essential for the sorting of MPP6.
    Title: Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine.
  3. The findings indicate that the Src-MPP6-4.1G protein complex in Schmidt-Lanterman incisures(SLIs) has a role in signal transduction in the peripheral nervous system(PNS).
    Title: Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS.
  4. In the mouse sciatic nerve, protein 4.1G colocalized at Schmidt-Lanterman incisures (SLI) and the paranodes with a member of the membrane-associated guanylate kinase (MAGUK) family, membrane protein palmitoylated 6.
    Title: Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanylate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein PALS2
Names
MAGUK p55 subfamily member 6
dlgh4 protein
fibroblast growth factor-inducible protein 15
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 6)
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
protein associated with Lin-7 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164733.2 → NP_001158205.1  protein PALS2 isoform a

    See identical proteins and their annotated locations for NP_001158205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 5-7 all encode isoform a.
    Source sequence(s)
    AC153618
    Consensus CDS
    CCDS51770.1
    UniProtKB/Swiss-Prot
    Q9JLB0, Q9JLB1, Q9WV37
    UniProtKB/TrEMBL
    Q3UN60
    Related
    ENSMUSP00000038772.9, ENSMUST00000036225.15
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:232 → 292
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:132 → 205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:350 → 540
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  2. NM_001164734.2 → NP_001158206.1  protein PALS2 isoform a

    See identical proteins and their annotated locations for NP_001158206.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 5-7 all encode isoform a.
    Source sequence(s)
    AC153618
    Consensus CDS
    CCDS51770.1
    UniProtKB/Swiss-Prot
    Q9JLB0, Q9JLB1, Q9WV37
    UniProtKB/TrEMBL
    Q3UN60
    Related
    ENSMUSP00000125880.2, ENSMUST00000166318.8
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:232 → 292
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:132 → 205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:350 → 540
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  3. NM_001361247.2 → NP_001348176.1  protein PALS2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC153618
    Consensus CDS
    CCDS20128.1
    UniProtKB/TrEMBL
    B9EHZ5
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:218 → 278
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:132 → 205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:336 → 526
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  4. NM_001361248.2 → NP_001348177.1  protein PALS2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC153618
    Consensus CDS
    CCDS51770.1
    UniProtKB/Swiss-Prot
    Q9JLB0, Q9JLB1, Q9WV37
    UniProtKB/TrEMBL
    Q3UN60
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:232 → 292
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:132 → 205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:350 → 540
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  5. NM_001411352.1 → NP_001398281.1  protein PALS2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC153618
    UniProtKB/Swiss-Prot
    Q9JLB0, Q9JLB1, Q9WV37
    UniProtKB/TrEMBL
    Q3UN60

  6. NM_001411353.1 → NP_001398282.1  protein PALS2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC153618
    UniProtKB/Swiss-Prot
    Q9JLB0, Q9JLB1, Q9WV37
    UniProtKB/TrEMBL
    Q3UN60

  7. NM_001411356.1 → NP_001398285.1  protein PALS2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC153618
    UniProtKB/TrEMBL
    B9EHZ5
    Related
    ENSMUSP00000144737.2, ENSMUST00000204545.3

  8. NM_001411358.1 → NP_001398287.1  protein PALS2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC153618
    UniProtKB/TrEMBL
    B9EHZ5

  9. NM_001411359.1 → NP_001398288.1  protein PALS2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC153618
    UniProtKB/TrEMBL
    B9EHZ5

  10. NM_001411360.1 → NP_001398289.1  protein PALS2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC153618
    UniProtKB/TrEMBL
    B9EHZ5

  11. NM_001411362.1 → NP_001398291.1  protein PALS2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC153618

  12. NM_001411366.1 → NP_001398295.1  protein PALS2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC153618

  13. NM_001411367.1 → NP_001398296.1  protein PALS2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC153618

  14. NM_019939.3 → NP_064323.2  protein PALS2 isoform b

    See identical proteins and their annotated locations for NP_064323.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8-11 all encode isoform b.
    Source sequence(s)
    AC153618
    Consensus CDS
    CCDS20128.1
    UniProtKB/TrEMBL
    B9EHZ5
    Related
    ENSMUSP00000039314.9, ENSMUST00000036236.15
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:218 → 278
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:132 → 205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:336 → 526
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    50087206..50176134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255518.2 → XP_030111378.1  protein PALS2 isoform X3

    Conserved Domains (4) summary
    cd12038
    Location:207 → 267
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:107 → 180
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:325 → 515
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:32 → 83
    L27; L27 domain

  2. XM_036152240.1 → XP_036008133.1  protein PALS2 isoform X1

    UniProtKB/Swiss-Prot
    Q9JLB0, Q9JLB1, Q9WV37
    UniProtKB/TrEMBL
    Q3UN60
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:232 → 292
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:132 → 205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:350 → 540
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_008016.2: Suppressed sequence

    Description
    NM_008016.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLB0.1 GenPept UniProtKB/Swiss-Prot:Q9JLB0

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