Nme4 NME/NM23 nucleoside diphosphate kinase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nme4provided by MGI
Official Full Name: NME/NM23 nucleoside diphosphate kinase 4provided by MGI
Primary source: MGI:MGI:1931148
See related: Ensembl:ENSMUSG00000024177 AllianceGenome:MGI:1931148
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nm23M4; NM23-M4; 2610027N22Rik; 2810024O08Rik; 5730493H09Rik
Summary: Predicted to enable cardiolipin binding activity and nucleoside diphosphate kinase activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within nucleotide metabolic process and phosphorylation. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and trigeminal ganglion. Orthologous to human NME4 (NME/NM23 nucleoside diphosphate kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 42.0), liver E14.5 (RPKM 28.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 13.06 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26310708..26314650, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (26091734..26095523, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NME4 mediates metabolic reprogramming and promotes nonalcoholic fatty liver disease progression.
Title: NME4 mediates metabolic reprogramming and promotes nonalcoholic fatty liver disease progression.
The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor.
Title: The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor.
A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation.
Title: A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cardiolipin binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleoside diphosphate kinase, mitochondrial

Names: NDK; NDP kinase, mitochondrial; NDPKD; expressed in non-metastatic cells 4, protein; non-metastatic cells 4, protein expressed in; nucleoside diphosphate kinase D

NP_062705.1

EC 2.7.4.6

XP_006524740.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019731.1 → NP_062705.1 nucleoside diphosphate kinase, mitochondrial precursor

See identical proteins and their annotated locations for NP_062705.1

Status: PROVISIONAL

Source sequence(s)

AF153451

Consensus CDS

CCDS28544.1

UniProtKB/Swiss-Prot

Q9WV84

UniProtKB/TrEMBL

Q9CS68

Related

ENSMUSP00000025007.6, ENSMUST00000025007.7

Conserved Domains (2) summary

cd04413
Location:37 → 166

NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...

pfam00334
Location:37 → 171

NDK; Nucleoside diphosphate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

26310708..26314650 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524677.5 → XP_006524740.1 nucleoside diphosphate kinase, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A494BA94

Related

ENSMUSP00000157943.2, ENSMUST00000236547.2

Conserved Domains (1) summary

cd04413
Location:57 → 203

NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...