Elf4 E74 like ETS transcription factor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elf4provided by MGI
Official Full Name: E74 like ETS transcription factor 4provided by MGI
Primary source: MGI:MGI:1928377
See related: Ensembl:ENSMUSG00000031103 AllianceGenome:MGI:1928377
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mef; Gm9907
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in NK T cell proliferation; natural killer cell proliferation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human ELF4 (E74 like ETS transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 29.1), spleen adult (RPKM 20.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A5; X 25.67 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (47499926..47552009, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (48411049..48463132, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization.
Title: The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization.
An ELF4 hypomorphic variant results in NK cell deficiency.
Title: An ELF4 hypomorphic variant results in NK cell deficiency.
that E74, like ETS transcription factor 4 (ELF4), a type I interferon activator, can help protect the host from Plasmodium yoelii infection.
Title: ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp.
Transcription factor ELF4 promotes development and function of memory CD8(+) T cells in Listeria monocytogenes infection.
Title: Transcription factor ELF4 promotes development and function of memory CD8(+) T cells in Listeria monocytogenes infection.
ELF4 restrains Th17 differentiation in dividing CD4(+) T cells by regulating commitment to the Th17 differentiation program.
Title: The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Data indicate that ELF4 is an type I interferon stimulator and binds to STING.
Title: ELF4 is critical for induction of type I interferon and the host antiviral response.
These studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.
Title: MEF promotes stemness in the pathogenesis of gliomas.
After gamma-irradiation, ATM phosphorylates ELF4, leading to its degradation; a mutant form of ELF4 that cannot be phosphorylated by ATM persists following gamma-irradiation, delaying the resolution of gammaH2AX foci and triggering an excessive DNA damage response.
Title: The mef/elf4 transcription factor fine tunes the DNA damage response.
These results suggest that MEF transactivates PPARgamma expression, which, in turn, enhances adipogenic differentiation.
Title: Myeloid Elf-1-like factor stimulates adipogenic differentiation through the induction of peroxisome proliferator-activated receptor γ expression in bone marrow.
transcriptional control of Elf-4 within the hematopoietic system and integration of Elf-4 into the wider transcriptional regulatory networks that govern hematopoietic development
Title: Integration of Elf-4 into stem/progenitor and erythroid regulatory networks through locus-wide chromatin studies coupled with in vivo functional validation.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV314029 (e-PCR)
- UniSTS:181287

Elf4 (e-PCR), detects polymorphism
- UniSTS:547213

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NK T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ETS-related transcription factor Elf-4

Names: E74-like factor 4 (ets domain transcription factor); E74-like factor 4; myeloid elf-1-like factor; myeloid elf-1 like factor; myeloid elf-1-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001381876.1 → NP_001368805.1 ETS-related transcription factor Elf-4

Status: VALIDATED

Source sequence(s)

AL669901, AL844594

UniProtKB/Swiss-Prot

B1AY67, Q9Z2U4

UniProtKB/TrEMBL

Q32MF0, Q3U2M4

Related

ENSMUSP00000110608.2, ENSMUST00000114958.8

Conserved Domains (2) summary

pfam00178
Location:209 → 289

Ets; Ets-domain

pfam12310
Location:2 → 103

Elf-1_N; Transcription factor protein N terminal
NM_019680.2 → NP_062654.2 ETS-related transcription factor Elf-4

See identical proteins and their annotated locations for NP_062654.2

Status: VALIDATED

Source sequence(s)

AL669901, AL844594

Consensus CDS

CCDS30108.1

UniProtKB/Swiss-Prot

B1AY67, Q9Z2U4

UniProtKB/TrEMBL

Q32MF0, Q3U2M4

Related

ENSMUSP00000033429.3, ENSMUST00000033429.9

Conserved Domains (2) summary

pfam00178
Location:209 → 289

Ets; Ets-domain

pfam12310
Location:2 → 103

Elf-1_N; Transcription factor protein N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

47499926..47552009 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006541527.1 → XP_006541590.1 ETS-related transcription factor Elf-4 isoform X1

See identical proteins and their annotated locations for XP_006541590.1

UniProtKB/Swiss-Prot

B1AY67, Q9Z2U4

UniProtKB/TrEMBL

Q32MF0, Q3U2M4

Conserved Domains (2) summary

pfam00178
Location:209 → 289

Ets; Ets-domain

pfam12310
Location:2 → 103

Elf-1_N; Transcription factor protein N terminal