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Gosr2 golgi SNAP receptor complex member 2 [ Mus musculus (house mouse) ]

Gene ID: 56494, updated on 11-Apr-2024

Summary

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Official Symbol
Gosr2provided by MGI
Official Full Name
golgi SNAP receptor complex member 2provided by MGI
Primary source
MGI:MGI:1927204
See related
Ensembl:ENSMUSG00000020946 AllianceGenome:MGI:1927204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gs27; SNARE; membrin; 2310032N09Rik
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Acts upstream of or within vesicle-mediated transport. Located in Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut gland; and respiratory system. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 6. Orthologous to human GOSR2 (golgi SNAP receptor complex member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 36.5), genital fat pad adult (RPKM 36.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E1; 11 67.43 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103567675..103590139, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103676849..103697723, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700072I22 gene Neighboring gene reprimo-like Neighboring gene RIKEN cDNA C130046K22 gene Neighboring gene wingless-type MMTV integration site family, member 9B Neighboring gene STARR-seq mESC enhancer starr_30857 Neighboring gene STARR-seq mESC enhancer starr_30858 Neighboring gene wingless-type MMTV integration site family, member 3 Neighboring gene STARR-seq mESC enhancer starr_30861 Neighboring gene VISTA enhancer mm1102 Neighboring gene N-ethylmaleimide sensitive fusion protein Neighboring gene predicted gene, 35365

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway. Xu Y, et al. J Biol Chem, 1998 Aug 21. PMID 9705316
  2. Mutations in Membrin/GOSR2 Reveal Stringent Secretory Pathway Demands of Dendritic Growth and Synaptic Integrity. Praschberger R, et al. Cell Rep, 2017 Oct 3. PMID 28978487, Free PMC Article
  3. A SNARE involved in protein transport through the Golgi apparatus. Lowe SL, et al. Nature, 1997 Oct 23. PMID 9349823
  4. Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice. Juriloff DM, et al. Birth Defects Res A Clin Mol Teratol, 2005 Feb. PMID 15690355
  5. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Hay JC, et al. Cell, 1997 Apr 4. PMID 9094723

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity.
    Title: Mutations in Membrin/GOSR2 Reveal Stringent Secretory Pathway Demands of Dendritic Growth and Synaptic Integrity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Golgi SNAP receptor complex member 2
Names
27 kDa Golgi SNARE protein
golgi SNARE

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362852.1 → NP_001349781.1  Golgi SNAP receptor complex member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627252, CA315963
    Conserved Domains (2) summary
    cd15863
    Location:119 → 184
    SNARE_GS27; SNARE motif of GS27
    cl26472
    Location:7 → 106
    DUF3084; Protein of unknown function (DUF3084)

  2. NM_001362853.1 → NP_001349782.1  Golgi SNAP receptor complex member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL627252
    Conserved Domains (2) summary
    cd15863
    Location:116 → 181
    SNARE_GS27; SNARE motif of GS27
    cl26472
    Location:6 → 103
    DUF3084; Protein of unknown function (DUF3084)

  3. NM_001362854.1 → NP_001349783.1  Golgi SNAP receptor complex member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627252
    Conserved Domains (1) summary
    cd15863
    Location:102 → 167
    SNARE_GS27; SNARE motif of GS27

  4. NM_001362855.1 → NP_001349784.1  Golgi SNAP receptor complex member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627252
    Conserved Domains (1) summary
    cd15863
    Location:102 → 167
    SNARE_GS27; SNARE motif of GS27

  5. NM_001362856.1 → NP_001349785.1  Golgi SNAP receptor complex member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627252
    Conserved Domains (1) summary
    cd15863
    Location:102 → 167
    SNARE_GS27; SNARE motif of GS27

  6. NM_001362857.1 → NP_001349786.1  Golgi SNAP receptor complex member 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL627252
    Conserved Domains (1) summary
    cd15863
    Location:91 → 156
    SNARE_GS27; SNARE motif of GS27

  7. NM_001362858.1 → NP_001349787.1  Golgi SNAP receptor complex member 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL627252, CA316919
    Consensus CDS
    CCDS88267.1
    UniProtKB/TrEMBL
    A2A9I0
    Related
    ENSMUSP00000102627.3, ENSMUST00000107013.3
    Conserved Domains (2) summary
    cl22856
    Location:113 → 138
    SNARE; SNARE motif
    cl25917
    Location:11 → 141
    Exonuc_VII_L; Exonuclease VII, large subunit

  8. NM_001362859.1 → NP_001349788.1  Golgi SNAP receptor complex member 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL627252
    Conserved Domains (1) summary
    cl22856
    Location:95 → 120
    SNARE; SNARE motif

  9. NM_001362860.1 → NP_001349789.1  Golgi SNAP receptor complex member 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL627252
    Conserved Domains (1) summary
    cl22856
    Location:95 → 120
    SNARE; SNARE motif

  10. NM_019650.4 → NP_062624.2  Golgi SNAP receptor complex member 2 isoform 1

    See identical proteins and their annotated locations for NP_062624.2

    Status: VALIDATED

    Source sequence(s)
    AK005697, AL627252
    Consensus CDS
    CCDS25521.1
    UniProtKB/Swiss-Prot
    O35166, Q3UDN0, Q9CR77
    Related
    ENSMUSP00000021329.8, ENSMUST00000021329.14
    Conserved Domains (2) summary
    cd15863
    Location:120 → 185
    SNARE_GS27; SNARE motif of GS27
    cl26472
    Location:7 → 107
    DUF3084; Protein of unknown function (DUF3084)

RNA

  1. NR_156185.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627252

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    103567675..103590139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246190.2 → XP_030102050.1  Golgi SNAP receptor complex member 2 isoform X2

    Conserved Domains (2) summary
    PRK00286
    Location:11 → 140
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cl22856
    Location:112 → 137
    SNARE; SNARE motif

  2. XM_030246189.1 → XP_030102049.1  Golgi SNAP receptor complex member 2 isoform X1

    Conserved Domains (1) summary
    cd15863
    Location:102 → 167
    SNARE_GS27; SNARE motif of GS27
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35166.2 GenPept UniProtKB/Swiss-Prot:O35166

Gene LinkOut

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