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Mtch1 mitochondrial carrier 1 [ Mus musculus (house mouse) ]

Gene ID: 56462, updated on 11-Apr-2024

Summary

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Official Symbol
Mtch1provided by MGI
Official Full Name
mitochondrial carrier 1provided by MGI
Primary source
MGI:MGI:1929261
See related
Ensembl:ENSMUSG00000024012 AllianceGenome:MGI:1929261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSAP; 2310034O17Rik
Summary
Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of apoptotic process. Predicted to act upstream of or within apoptotic process. Located in mitochondrion. Is expressed in cerebral cortex marginal layer; choroid invagination; diencephalon roof plate; metencephalon part of 4th ventricle choroid plexus; and thyroid gland. Orthologous to human MTCH1 (mitochondrial carrier 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 154.2), genital fat pad adult (RPKM 153.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 15.23 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29551050..29566921, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29332076..29347947, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 10045 Neighboring gene predicted gene, 46603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29469332-29469441 Neighboring gene peptidase inhibitor 16 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29475389-29475661 Neighboring gene STARR-positive B cell enhancer ABC_E4202 Neighboring gene STARR-positive B cell enhancer ABC_E5586 Neighboring gene STARR-positive B cell enhancer ABC_E7508 Neighboring gene FYVE, RhoGEF and PH domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E10944 Neighboring gene STARR-seq mESC enhancer starr_42277 Neighboring gene STARR-seq mESC enhancer starr_42278 Neighboring gene STARR-positive B cell enhancer ABC_E2478 Neighboring gene STARR-positive B cell enhancer ABC_E8664 Neighboring gene VISTA enhancer mm81 Neighboring gene STARR-positive B cell enhancer mm9_chr17:29574287-29574588 Neighboring gene predicted gene, 36486 Neighboring gene predicted gene, 36199

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Both the N-terminal fragment and the protein-protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAP. Mao G, et al. Biochim Biophys Acta, 2008 Apr. PMID 18291114, Free PMC Article
  2. The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development. Nacarino-Palma A, et al. Stem Cell Reports, 2021 Sep 14. PMID 34478649, Free PMC Article
  3. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial carrier homolog 1
Names
mitochondrial carrier-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347335.1 → NP_001334264.1  mitochondrial carrier homolog 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162182, CD740861
    Consensus CDS
    CCDS84288.1
    UniProtKB/Swiss-Prot
    Q791T5
    Related
    ENSMUSP00000113021.2, ENSMUST00000118366.9
    Conserved Domains (1) summary
    pfam00153
    Location:206 → 264
    Mito_carr; Mitochondrial carrier protein

  2. NM_001357762.1 → NP_001344691.1  mitochondrial carrier homolog 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA215277, AC162182
    Consensus CDS
    CCDS89048.1
    UniProtKB/TrEMBL
    A0A3Q4EBT8, A0A3Q4EC24
    Related
    ENSMUSP00000157010.2, ENSMUST00000234507.2
    Conserved Domains (1) summary
    pfam00153
    Location:94 → 152
    Mito_carr; Mitochondrial carrier protein

  3. NM_001357763.1 → NP_001344692.1  mitochondrial carrier homolog 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA215277, AC162182
    Consensus CDS
    CCDS89049.1
    UniProtKB/TrEMBL
    A0A3Q4EG99, D3YXC2
    Related
    ENSMUSP00000157094.2, ENSMUST00000235088.2
    Conserved Domains (1) summary
    pfam00153
    Location:94 → 152
    Mito_carr; Mitochondrial carrier protein

  4. NM_019880.4 → NP_063933.1  mitochondrial carrier homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_063933.1

    Status: VALIDATED

    Source sequence(s)
    AC162182
    Consensus CDS
    CCDS28596.1
    UniProtKB/Swiss-Prot
    Q3U4W7, Q791T5, Q791V6, Q8R0T0, Q8R1T8, Q8R2T2, Q9QZA5, Q9QZP4
    Related
    ENSMUSP00000093077.5, ENSMUST00000095427.12
    Conserved Domains (1) summary
    pfam00153
    Location:206 → 264
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29551050..29566921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524668.2 → XP_006524731.1  mitochondrial carrier homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006524731.1

    UniProtKB/Swiss-Prot
    Q3U4W7, Q791T5, Q791V6, Q8R0T0, Q8R1T8, Q8R2T2, Q9QZA5, Q9QZP4
    Conserved Domains (1) summary
    pfam00153
    Location:206 → 264
    Mito_carr; Mitochondrial carrier protein

  2. XM_006524670.3 → XP_006524733.1  mitochondrial carrier homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006524733.1

    UniProtKB/Swiss-Prot
    Q791T5
    Conserved Domains (1) summary
    pfam00153
    Location:206 → 264
    Mito_carr; Mitochondrial carrier protein

  3. XM_036160691.1 → XP_036016584.1  mitochondrial carrier homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q4EBT8, A0A3Q4EC24
    Related
    ENSMUSP00000157218.2, ENSMUST00000235021.2
    Conserved Domains (1) summary
    pfam00153
    Location:94 → 152
    Mito_carr; Mitochondrial carrier protein

  4. XM_030249918.2 → XP_030105778.1  mitochondrial carrier homolog 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q4EG99, D3YXC2
    Related
    ENSMUSP00000115027.3, ENSMUST00000153658.3
    Conserved Domains (1) summary
    pfam00153
    Location:94 → 152
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q791T5.1 GenPept UniProtKB/Swiss-Prot:Q791T5

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